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Yasuhiro Goto

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Publication

Featured researches published by Yasuhiro Goto.

Bioorganic & Medicinal Chemistry Letters | 2003

N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.

Masaaki Hirose; Shinichiro Egashira; Yasuhiro Goto; Takashi Hashihayata; Norikazu Ohtake; Hisashi Iwaasa; Mikiko Hata; Takehiro Fukami; Akio Kanatani; Koji Yamada

Journal of Medicinal Chemistry | 2006

Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.

Yasuhiro Goto; Sachie Arai-Otsuki; Yukari Tachibana; Daisuke Ichikawa; Satoshi Ozaki; Hiroyuki Takahashi; Yoshikazu Iwasawa; Osamu Okamoto; Shoki Okuda; Hisashi Ohta; Takeshi Sagara

Archive | 2009

NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY

Yasuhiro Goto; Takeshi Sagara; Weiming Fan; Thomas F. N. Hacell; Matthew G. Jenks; Michael J. Malaska; Joseph A. Moore; Gilles Ouvry; Bharathi Pandi; Michael R. Peel; Kimberty M. Steward

Journal of Medicinal Chemistry | 2009

Identification of an orally active opioid receptor-like 1 (ORL1) receptor antagonist 4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropan]-3-ylmethyl]piperidine as clinical candidate.

Atsushi Satoh; Takeshi Sagara; Hiroki Sakoh; Masaya Hashimoto; Hiroshi Nakashima; Tetsuya Kato; Yasuhiro Goto; Sayaka Mizutani; Tomoko Azuma-Kanoh; Takeshi Tani; Shoki Okuda; Osamu Okamoto; Satoshi Ozaki; Yoshikazu Iwasawa; Hisashi Ohta; Hiroshi Kawamoto

Archive | 2002

Spiropiperidine derivatives, nociceptin receptor antagonists containing the same as the active ingredient and medicinal compositions

Takeshi Sagara; Satoru Itoh; Hiroshi Nakashima; Yasuhiro Goto; Atsushi Shimizu; Yoshikazu Iwasawa; Osamu Okamoto

Tetrahedron-asymmetry | 2009

Efficient and practical asymmetric synthesis of 1-tert-butyl 3-methyl (3R,4R)-4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidine-1,3-dicarboxylate, a useful intermediate for the synthesis of nociceptin antagonists

Hideki Jona; Jun Shibata; Masanori Asai; Yasuhiro Goto; Sachie Arai; Shigeru Nakajima; Osamu Okamoto; Hiroshi Kawamoto; Yoshikazu Iwasawa

Chemical & Pharmaceutical Bulletin | 2002

Synthesis of the side chain of a novel carbapenem via iodine-mediated oxidative cyclization of (1R)-N-(1-aryl-3-butenyl)acetamide.

Takashi Hashihayata; Hiroaki Sakoh; Yasuhiro Goto; Koji Yamada; Hajime Morishima

Archive | 2009

Substituted [1,2,4]triazolo[4′,3′:1,6]pyrido[2,3-b]pyrazines of the formula D

Hidetomo Furuyama; Yasuhiro Goto; Nobuhiko Kawanishi; Mark E. Layton; Takashi Mita; Akira Naya; Yoshio Ogino; Yu Onozaki; Kevin J. Rodzinak; Toshihiro Sakamoto; Philip E. Sanderson; Jiabing Wang

Archive | 2007

Substituted pyrazolo[3,4-d]pyrimidinone derivatives

Takeshi Sagara; Sachie Otsuki; Satoshi Sunami; Toshihiro Sakamoto; Kenji Niiyama; Fuyuki Yamamoto; Takashi Yoshizumi; Hidetomo Furuyama; Yasuhiro Goto; Makoto Bamba; Keiji Takahashi; Hiroshi Hirai; Toshihide Nishibata

Chemical & Pharmaceutical Bulletin | 2001

Diastereoselective Synthesis of (2R,4R)-2-Aryl-4-hydroxypyrrolidine: Preparation of the Side Chain of Novel Carbapenem

Takashi Hashihayata; Hiroki Sakoh; Yasuhiro Goto; Masaaki Hirose; Shunji Sakuraba; Hideaki Imamura; Yuichi Sugimoto; Koji Yamada; Hajime Morishima

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Collaboration

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Takeshi Sagara

Kyushu University

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Osamu Okamoto

Merck

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Yoshikazu Iwasawa

Merck

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Toshihiro Sakamoto

Kyushu University

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Kenji Niiyama

Nagoya University

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Koji Yamada

College of Industrial Technology

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Hiroshi Hirai

Merck

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Hiroshi Nakashima

Brigham and Women's Hospital

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Sachie Otsuki

Merck

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Satoshi Sunami

Merck

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