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Dive into the research topics where Yasuhiro Kazuki is active.

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Featured researches published by Yasuhiro Kazuki.


Cloning & Transgenesis | 2014

Toward Gene and Cell Therapies Employing Human Artificial Chromosomes in Conjunction with Stem Cells

Narumi Uno; Yasuhiro Kazuki; Mitsuo Oshimura

Various Stem cells including induced pluripotent stem cells (iPSCs) are expected to contribute to the development of regenerative medicines. Human artificial chromosome (HAC) vectors have no limits with respect to the size of inserts, and are independently maintained from host chromosomes. HACs could be promising vectors that will contribute to gene and cell therapy in the future. Various applications and methods have been developed using HAC vectors; however, in this review we introduce current research focused towards gene and cell therapy of Duchenne muscular dystrophy and hemophilia A using stem cells. In addition, HAC vectors to generate iPSCs, with a safeguard system to eliminate tumorigenic cells are proposed.


Archive | 2007

Human artificial chromosome (hac) vector, and human cell pharmaceutical comprising human artificial chromosome (hac) vector

Minoru Kakeda; Kazuma Tomizuka; Mitsuo Oshimura; Yasuhiro Kazuki


Archive | 2007

HUMAN ARTIFICIAL CHROMOSOME (HAC) VECTOR AND HUMAN CELL MEDICINE COMPRISING SAME

Minoru Kakeda; Kazuma Tomizuka; Mitsuo Oshimura; Yasuhiro Kazuki


Archive | 2008

Mammalian artificial chromosome vector carrying human cytochrome p450 gene (cluster), and non-human mammal harboring the vector

Mitsuo Oshimura; Yasuhiro Kazuki; Takashi Matsuoka; Kazuma Tomizuka; Takeshi Oshima


The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017

Development of investigation to determine the cause of disease and therapeutics by chromosome medical engineering

Hiroyuki Kugoh; Narumi Uno; Takahito Ohira; Masaharu Hiratsuka; Yasuhiro Kazuki; Mitsuo Oshimura


The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017

Construction of luciferase complementation assay for G protein-coupled receptor activation using mouse artificial chromosomes

Uno Narumi; Tomohito Fujimoto; Shinya Komoto; Masaaki Sawa; Yasuhiro Kazuki; Mitsuo Oshimura


The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017

Region specific differentiation of ES cells into forebrain neural progenitors via a dual-monitor HAC

Masaharu Hiratsuka; Shota Togai; Gohta Shinotani; Mitsuhiko Osaki; Yasuhiro Kazuki; Mitsuo Oshimura


Archive | 2008

ヒトチトクロームp450遺伝子(クラスター)を含む哺乳動物人工染色体ベクター及びそれを保持する非ヒト哺乳動物

Mitsuo Oshimura; Yasuhiro Kazuki; Takashi Matsuoka; Kazuma Tomizuka; Takeshi Oshima


Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics | 2008

CONSTRUCTION AND EVALUATION OF CYP3A-HAC MICE WITH THE HUMAN CYP3A CLUSTER FOR DRUG-DRUG INTERACTION STUDY

Kaoru Kobayashi; Kan Chiba; Kazuma Tomizuka; Yasuhiro Kazuki; Mitsuo Oshimura


Archive | 2007

Vecteur de chromosome artificiel humain (cah), et substance pharmaceutique à base de cellules humaines contenant un vecteur de chromosome artificiel humain (cah)

Minoru Kakeda; Kazuma Tomizuka; Mitsuo Oshimura; Yasuhiro Kazuki

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