Yasuhiro Kazuma
Kyoto University
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Publication
Featured researches published by Yasuhiro Kazuma.
Biochemical and Biophysical Research Communications | 2016
Wataru Maruyama; Kotaro Shirakawa; Hiroyuki Matsui; Tadahiko Matsumoto; Hiroyuki Yamazaki; Anamaria Daniela Sarca; Yasuhiro Kazuma; Masayuki Kobayashi; Keisuke Shindo; Akifumi Takaori-Kondo
APOBEC3B (A3B) is a DNA cytosine deaminase and catalyzes cytosine deamination, resulting in mutations in genomic DNA. A3B is aberrantly expressed in a variety of cancers and considered to be a source of genomic mutations that contribute to cancer progression and metastasis. However, the mechanisms through which A3B expression is dysregulated in cancer cells are not fully elucidated. Here we report that the classical NF-κB pathway plays a crucial role in the transcriptional regulation of A3B in various cancer cells, including lymphoid malignancies. PMA, a strong activator of PKC, induces A3B at both mRNA and protein levels in cancer cell lines, and specific inhibitors of both PKC and IKK downregulate A3B expression. Using luciferase reporter and EMSA assays, we identify 3 NF-κΒ binding sites in the A3B promoter and reveal that NF-κB p65/p50 and p65/c-Rel heterodimers are important for A3B transcription. These results suggest that the classical NF-κB pathway is responsible for activation of A3B mRNA expression and further imply that inhibition of PKC and IKK might augment cancer treatment by reducing cancer progression and metastasis through downregulation of A3B expression.
Haematologica | 2018
Yotaro Ochi; Nobuhiro Hiramoto; Tetsuichi Yoshizato; Yuichiro Ono; June Takeda; Yusuke Shiozawa; Kenichi Yoshida; Nobuyuki Kakiuchi; Yuichi Shiraishi; Hiroko Tanaka; Kenichi Chiba; Yasuhiro Kazuma; Sumie Tabata; Noboru Yonetani; Keiichiro Uehara; Daisuke Yamashita; Yukihiro Imai; Koji Nagafuji; Mitsunori Yamakawa; Satoru Miyano; Akifumi Takaori-Kondo; Seishi Ogawa; Takayuki Ishikawa
Interdigitating dendritic cell sarcoma (IDCS) is a rare neoplasm considered to derive from a dendritic cell. Recent studies have shown that B- or T-lymphoblastic leukemia/lymphomas can develop clonally related histiocytic/dendritic cell (H/DC) neoplasms, such as histiocytic sarcoma, Langerhans cell
Internal Medicine | 2017
Yuichiro Ono; Yasuhiro Kazuma; Yotaro Ochi; Ryosuke Matsuoka; Yukihiro Imai; Takayuki Ishikawa
Neurolymphomatosis is a rare entity defined as nerve infiltration by neurotropic abnormal lymphocytes which can lead to the development of neuropathy, with typical presentations including pain, hypoesthesia, paresthesis and palsy. We herein report two cases where critical bilateral vocal cord paralysis due to neurolymphomatosis in recurrent nerves occurred in refractory Burkitt lymphoma and adult T-cell lymphoma patients. High-dose methotrexate and intrathecal chemotherapy injection for the nervous lesions were ineffective, and the patients died. Neurolymphomatosis of the recurrent nerve is an emergent and difficult complication and should be suspected when sudden onset of aphasia, hoarseness or shortness of breath is found in refractory lymphoma patients.
Annals of Hematology | 2017
Yotaro Ochi; Yasuhiro Kazuma; Nobuhiro Hiramoto; Yuichiro Ono; Satoshi Yoshioka; Noboru Yonetani; Yukihiro Imai; Hisako Hashimoto; Takayuki Ishikawa
Journal of Hematopoietic Cell Transplantation | 2017
Yosuke Nagahata; Yuichiro Ono; Yotaro Ochi; Yusuke Koba; Yasuhiro Kazuma; Nobuhiko Yamauchi; Nobuhiro Hiramoto; Sumie Tabata; Noboru Yonetani; Hisako Hashimoto; Takayuki Ishikawa
Blood | 2016
Tadahiko Matsumoto; Kotaro Shirakawa; Hiroyuki Matsui; Hiroyuki Yamazaki; Yasuhiro Kazuma; Anamaria Daniela Sarca; Hirofumi Fukuda; Wataru Maruyama; Akifumi Takaori-Kondo
Blood | 2014
Nobuhiko Yamauchi; Yusuke Koba; Yotaro Ochi; Yasuhiro Kazuma; Yosuke Nagahata; Yuichiro Ono; Nobuhiro Hiramoto; Sumie Tabata; Noboru Yonetani; Hisako Hashimoto; Yukihiro Imai; Takayuki Ishikawa
Blood | 2014
Yasuhiro Kazuma; Kazunari Aoki; Yotaro Ochi; Yusuke Koba; Yoshimitsu Shimomura; Yosuke Nagahata; Nobuhiko Yamauchi; Yuichiro Ono; Nobuhiro Hiramoto; Sumie Tabata; Noboru Yonetani; Hisako Hashimoto; Takayuki Ishikawa
Blood | 2013
Yosuke Nagahata; Yasuhiro Kazuma; June Takeda; Yuki Funayama; Yuichiro Ono; Nobuhiro Hiramoto; Sumie Tabata; Noboru Yonetani; Hisako Hashimoto; Takayuki Ishikawa
Blood | 2013
June Takeda; Hayato Maruoka; Yasuhiro Kazuma; Nobuhiro Hiramoto; Nobuhiko Yamauchi; Yosuke Nagahata; Yuki Funayama; Yotaro Ochi; Yusuke Koba; Sumie Tabata; Noboru Yonetani; Koji Nasu; Takayuki Takahashi; Hisako Hashimoto; Takayuki Ishikawa