Yasuhiro Yaguchi
Hamamatsu University
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Featured researches published by Yasuhiro Yaguchi.
American Journal of Physiology-heart and Circulatory Physiology | 2009
Masao Saotome; Hideki Katoh; Yasuhiro Yaguchi; Takamitsu Tanaka; Tsuyoshi Urushida; Hiroshi Satoh; Hideharu Hayashi
Reactive oxygen species (ROS) production during ischemia-reperfusion (I/R) is thought to be a critical factor for myocardial injury. However, a small amount of ROS during the ischemic preconditioning (IPC) may provide a signal for cardioprotection. We have previously reported that the repetitive pretreatment of a small amount of ROS [hydrogen peroxide (H(2)O(2)), 2 microM] mimicked the IPC-induced cardioprotection in the Langendorff-perfused rat hearts. We further investigated the mechanisms of the ROS-induced cardioprotection against I/R injury and tested the hypothesis whether it could mediate the mitochondrial permeability transition pore (mPTP) opening. The Langendorff-perfused rat hearts were subjected to 35 min ischemia and 40 min reperfusion, and the pretreatment of H(2)O(2) (2 microM) significantly improved the postischemic recoveries in left ventricular developed pressure, intracellular phosphocreatine, and ATP levels. A specific mPTP inhibitor cyclosporin A (CsA; 0.2 microM) canceled these H(2)O(2)-induced effects. In isolated permeabilized myocytes, H(2)O(2) (1 microM) accelerated the calcein leakage from mitochondria in a CsA-sensitive manner, indicating the opening of mPTP by H(2)O(2). However, H(2)O(2) did not depolarize mitochondrial membrane potential (DeltaPsi(m)) even in the presence of oligomycin (F(1)/F(0) ATPase inhibitor; 1 microM) and decreased mitochondrial Ca(2+) concentration ([Ca(2+)](m)) by accelerating the mitochondrial Ca(2+) extrusion via an mPTP. We conclude that the transient mPTP opening could be involved in the H(2)O(2)-induced cardioprotection against reperfusion injury, and the reduction of [Ca(2+)](m) without the change in DeltaPsi(m) might be a possible mechanism for the protection.
Circulation | 2003
Yasuhiro Yaguchi; Hiroshi Satoh; Nobuyuki Wakahara; Hideki Katoh; Akihiko Uehara; Hajime Terada; Yutaka Fujise; Hideharu Hayashi
Circulation | 2004
Nobuyuki Wakahara; Hideki Katoh; Yasuhiro Yaguchi; Akihiko Uehara; Hiroshi Satoh; Hajime Terada; Yutaka Fujise; Hideharu Hayashi
Journal of Molecular and Cellular Cardiology | 2008
Masao Saotome; Takamitsu Tanaka; Mamoru Nobuhara; Hideki Katoh; Yasuhiro Yaguchi; Tsuyoshi Urusida; Hiroshi Satoh; Hideharu Hayashi
Japanese Circulation Journal-english Edition | 2008
Kei Iida; Kazuyuki Sakata; Yasuhiro Yaguchi; Nao Mochiduki
Japanese Circulation Journal-english Edition | 2007
Kazuyuki Sakata; Kei Iida; Yasuhiro Yaguchi
Japanese Circulation Journal-english Edition | 2006
Kei Iida; Kazuyuki Sakata; Yasuhiro Yaguchi
Japanese Circulation Journal-english Edition | 2003
Fumitaka Matoh; Akihiko Uehara; Tomoyasu Nakano; Toshihiko Sugi; Tsuyoshi Urushida; Masaki Matsunaga; Keisuke Yamazaki; Yasuhiro Yaguchi; Kazuhiko Takeuchi; Nobuyuki Wakahara; Masao Saotome; Mariko Ozeki; Hideki Katou; Hiroshi Satoh; Hajime Terada; Hideharu Hayashi; Chinori Kurata; Hiroshi Watanabe; Kyoichi Ohhashi
Japanese Circulation Journal-english Edition | 2003
Nobuyuki Wakahara; Hideki Katou; Yasuhiro Yaguchi; Akihiko Uehara; Hiroshi Satoh; Hajime Terada; Hideharu Hayashi
Japanese Circulation Journal-english Edition | 2003
Yasuhiro Yaguchi; Hiroshi Satoh; Nobuyuki Wakahara; Hideki Katoh; Akihiko Uehara; Hajime Terada; Hideharu Hayashi