Yasuhito Miyake

Self-organized honeycomb-patterned microporous polystyrene thin films fabricated by calix[4]arene derivatives.

Calix[4]arene derivatives bearing carboxyl groups at the upper rim and alkyl groups at the lower rim were synthesized. Micrometer-size porous honeycomb-patterned thin films were prepared by evaporating chloroform solution of polystyrene containing the calixarene derivatives under high humidity. These films were coated on gold electrodes of QCM, and the high-frequency changes were observed to detect volatile organic compounds such as dichlorobenzene.

Excellent enantio-selective enclathration of (2R,3S)-3-methyl-2-pentanol in channel-like cavity of 3-epideoxycholic acid, interpreted by the four-location model for chiral recognition

Pure (2R,3S)-3-methyl-2-pentanol is resolved from the racemates by a steroidal host; the interpretation of the recognition mechanism based on the crystal structure reveals that CH/O interaction between the host and guest plays a decisive role in enantio-selective enclathration of the small aliphatic secondary alcohol.

Novel channel-type inclusion compounds of 3-epiursodeoxycholic acid

A new host, 3-epiursodeoxycholic acid, forms inclusion crystals with naphthalene derivatives with 1:1 stoichiometry.

Combinatorial Chemistry of Inclusion Compounds by using Steroids

Abstract Steroidal acids and their derivatives form inclusion compounds with a variety of organic substances. Over one thousand derivatives are candidates for hosts of the compounds. The study on steroidal inclusion compounds provides systematic data for considering relationships between molecular structures and molecular assemblies, indicating that combinatorial chemistry can be applied to inclusion chemistry.

A novel molecular assembly mode of ferulic acid derivatives

Ferulic acid derivative assembles with three kinds of non-covalent interactions, i.e., metal coordination, hydrogen bonding and CH-pi interaction: X-ray crystallographic study illustrated the molecular assembly mode.

Rapid and convenient laboratory method for the preparation of p-tert-butylcalix[4]arene using microwave irradiation

Rapid preparation of p-tert-butylcalix[4]arene using microwave irradiation was studied and p-tert-butylcalix[4]arene was obtained as a pure form in modest yield with shortening the reaction time from hours to minutes.

Inclusion Compounds of Hyocholic Acid with Specific Alcohols

Abstract Hyocholic acid forms lattice-type inclusion compounds with specific aliphatic alcohols. In these compounds, water molecules are also included and they play an important role in the formation of inclusion spaces.

Dimerization of ferulic acid and structure determination of phenylindane derivatives

Ferulic acid dimers with phenylindane skeletons were obtained from ferulic acid 1 in an acidic ethanol solution. The reaction conditions used to prepare the dimers or the ester were examined in detail, and the stereochemistries of the dimers were determined. The structural features of the dimers and the diastereoselective formation mechanisms involved in forming the two types of dimers (the racemic diastereomer 8α, which was a major product, and the racemic diastereomer 8γ, which was a minor product) were characterized.