Yasumiko Sakamoto
Kumamoto University
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Acta Radiologica | 1989
Yasuyuki Yamashita; M. Takahashi; Yasumiko Sakamoto; Ryutaro Kojima
Twenty-nine patients with atlantoaxial subluxation (18 with rheumatoid arthritis, 2 due to trauma, 4 with os odontoideum, and one each with polyarteritis nodosa, rheumatic fever, Klippel-Feil syndrome, achondroplasia, and cause unknown) were evaluated using a 0.22 tesla resistive MRI unit. Cord compression was classified into four grades according to the degree on magnetic resonance imaging. There were 7 patients with no thecal sac compression (grade 0), 10 with a minimal degree of subarachnoid space compression without cord compression (grade 1), 7 with mild cord compression (grade 2), and 5 with severe cord compression or cord atrophy (grade 3). Although the severity of myelopathy showed poor correlation with the atlantodental interval on conventional radiography, high correlation was observed between MR grading and the degree of myelopathy. The high signal intensity foci were observed in 7 of 12 patients with cord compression (grades 2 and 3) on T2 weighted images. Other frequently observed findings in rheumatoid arthritis included soft tissue masses of low to intermediate signal intensity in the paraodontoid space, erosions of the odontoid processes, and atlantoaxial impaction on T1 and T2 weighted images.
Modern Rheumatology | 2012
Hidenori Ichiyasu; Yuko Horio; Shinsuke Tsumura; Susumu Hirosako; Yasumiko Sakamoto; Shinya Sakata; Kei Ichi Nakashima; Taiyo Komatsu; Keisuke Kojima; Aiko Masunaga; Kazuhiko Fujii; Naoki Saita; Hirotsugu Kohrogi
We present 3 cases of rapidly progressive interstitial pneumonia (RPIP) associated with clinically amyopathic dermatomyositis (C-ADM) that were treated with two courses of direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP). Despite initial treatment with high-dose corticosteroids, pulsed cyclophosphamide, and cyclosporine, the lung disease and hypoxemia deteriorated in all the patients. After PMX-DHP treatment, the PaO2/FiO2 ratio and serum LDH and KL-6 were improved, the abnormal shadows in chest high-resolution computed tomography (HRCT) scans gradually decreased, and, finally, all patients survived. These findings indicate that PMX-DHP treatment could be effective in the management of RPIP in patients with C-ADM in combination with conventional therapy.
Respiratory medicine case reports | 2017
Hidenori Ichiyasu; Yasumiko Sakamoto; Chieko Yoshida; Kazuhiko Sakamoto; Ryosuke Fujita; Go Nakayama; Hiroko Okabayashi; Sho Saeki; Shinichiro Okamoto; Hirotsugu Kohrogi
The anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is a marker of clinically amyopathic dermatomyositis (CADM) and rapidly progressive interstitial lung disease (ILD) with acute respiratory failure. A 35-year-old woman with cervical cancer showed Gottrons papules, severe hypoxemia, and diffuse ground-glass opacities on chest computed tomography. She was diagnosed with rapidly progressive ILD associated with CADM. Her serum was positive for the anti-MDA-5 antibody. Combination therapy with corticosteroids, immunosuppressants, and direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP) improved her respiratory dysfunction. Eventually, surgery for the cancer was performed successfully. This is the first case to demonstrate the efficacy of PMX-DHP for rapidly progressive ILD with anti-MDA-5 antibody-positive CADM and a malignancy.
Therapeutic Advances in Respiratory Disease | 2017
Hidenori Ichiyasu; Yuko Horio; Aiko Masunaga; Yohei Migiyama; Yasumiko Sakamoto; Takayuki Jodai; Hideharu Ideguchi; Hiroko Okabayashi; Shohei Hamada; Chieko Yoshida; Susumu Hirosako; Shinichiro Okamoto; Hirotsugu Kohrogi
Background: Direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP) therapy has been approved for sepsis-associated acute respiratory distress syndrome, but its efficacy for other rapidly progressive interstitial pneumonias (RPIPs) is unclear. The purpose of this study was to examine the efficacy of PMX-DHP therapy for acute respiratory failure in patients with RPIPs, when compared with a historical control receiving conventional treatment without PMX-DHP. Methods: This study comprised 77 patients with RPIPs in our institute between January 2002 and December 2015. The initial 36 patients between January 2002 and March 2007 were treated without PMX-DHP (historical control group), and the following 41 patients between April 2007 and December 2015 were treated with PMX-DHP (PMX-DHP group) once daily for two successive days concurrently with corticosteroids and/or immunosuppressive agents. The 90-day mortality and clinical factors were compared between the groups. Cox proportional hazards models were constructed to analyze 90-day mortality and identify predictors. Results: The 90-day mortality rate was significantly lower in the PMX-DHP group than in the controls (41.5% versus 66.7%, p = 0.019). PMX-DHP therapy was significantly associated with mortality (hazard ratio 0.505; 95% confidence interval, 0.270–0.904; p = 0.032). There were significant differences in the serial changes in the PaO2/FiO2 ratio, SOFA score, and blood neutrophil counts from days 0–5 after PMX-DHP between the survivor and non-survivor groups (p = 0.015, p < 0.001, p = 0.035, respectively). The improved PaO2/FiO2 ratio on day 3 significantly correlated with the change in blood neutrophil counts (rs = −0.431, p = 0.006). Conclusions: PMX-DHP therapy may be effective in RPIPs patients accompanied by acute respiratory failure and is expected to reduce mortality rates.
Internal Medicine | 2018
Shinya Sakata; Yasumiko Sakamoto; Akira Takaki; Shiho Ishizuka; Sho Saeki; Kazuhiko Fujii
Pseudomesotheliomatous carcinoma of the lung is very rare, and reversible restrictive lung disease with pseudomesotheliomatous carcinoma has not yet been previously reported. We herein report a patient with HER2-positive non-small-cell lung cancer (NSCLC) showing pseudomesotheliomatous carcinoma who was successfully treated with bevacizumab combination chemotherapy. A 56-year-old Japanese woman with advanced NSCLC presented with dyspnea. We administered chemotherapy with cisplatin (75 mg/m2) plus pemetrexed (500 mg/m2) plus bevacizumab (15 mg/kg), followed by pemetrexed plus bevacizumab. After eight cycles of maintenance chemotherapy, chest CT demonstrated a marked tumor reduction and an improvement of the right lung volume. The vital capacity was thereafter found to have significantly increased according to pulmonary function tests.
Internal Medicine | 2018
Kosuke Imamura; Shinya Sakata; Yasumiko Sakamoto; Sho Saeki
A 58-year-old woman presented with chest pain and dyspnea. Chest computed tomography (CT) revealed a bulky mediastinal mass compressing the trachea and enlargement of the contralateral hilar lymph nodes (Picture 1). Endobronchial ultrasound-guided transbronchial needle aspiration was performed, and the pathological diagnosis was small-cell lung cancer (SCLC). Bone scintigraphy revealed the RI (Radioisotope) uptake in the sternoclavicular joints. However, CT showed no metastasis to the bone (Picture 1). Tenderness of the sternoclavicular joint, acne, palmoplantar pustulosis of hands and planta pedis were observed. Based on these findings, we diagnosed the patient with “synovitis, acne, pustulosis, hyperostosis, osteitis” (SAPHO) syndrome (Picture 2). The patient received platinum-based chemotherapy (carboplatin AUC 5 on day 1; etoposide 100 mg/m on days 1, 2 and 3) for 4 cycles without concurrent radiotherapy because of contralateral hilar lymph node metastasis. Chest CT revealed a marked reduction of the tumor (Picture 3). The tenderness of the sternoclavicular joint and the skin findings gradually improved and disappeared after chemotherapy (Picture 4). SAPHO syndrome is a rare disorder, and few cases with comorbid lung cancer have been re-
Clinical Case Reports | 2017
Mari Miyawaki; Seitaro Oda; Kenichiro Hirata; Hideaki Yuki; Daisuke Utsunomiya; Hidetaka Hayashi; Yasumiko Sakamoto; Shinichiro Okamoto; Kazuhiko Fujii; Yasuyuki Yamashita
Granulomatosis with polyangiitis (GPA) is characterized by necrotizing granulomatous inflammation usually involving the upper and lower respiratory tracts and necrotizing vasculitis predominantly affecting small‐sized vessels. Although categorized as a small vessel vasculitis, GPA can cause periaortitis and pericarditis. Physicians should recognize all categories of vasculitis can affect any size arteries.
Journal of Clinical Oncology | 2017
Sho Saeki; Jiichiro Sasaki; Shinya Sakata; Ryo Sato; Koichi Saruwatari; Yasumiko Sakamoto; Megumi Inaba; Hiroto Kishi; Shinji Fujii; Shinsuke Tsumura; Mayu Ouchi; Hideyuki Saito; Akinobu Hamada; Hirotsugu Kohrogi
BMC Pulmonary Medicine | 2017
Hiroko Okabayashi; Hidenori Ichiyasu; Sayuri Hirooka; Kimitaka Akaike; Keisuke Kojima; Takayuki Jodai; Yasumiko Sakamoto; Hideharu Ideguchi; Shohei Hamada; Chieko Yoshida; Susumu Hirosako; Shinichiro Okamoto; Hirotsugu Kohrogi
american thoracic society international conference | 2012
Yuko Horio; Hidenori Ichiyasu; Aiko Masunaga; Yasumiko Sakamoto; Shinya Sakata; Shinsuke Tsumura; Keisuke Kojima; Syo Saeki; Susumu Hirosako; Shinichiro Okamoto; Kazuhiko Fujii; Naoki Saita; Hirotsugu Kohrogi