Yasunori Moritani
Mitsubishi Tanabe Pharma
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Publication
Featured researches published by Yasunori Moritani.
Bioorganic & Medicinal Chemistry Letters | 2018
Hiroshi Miyazaki; Yousuke Ikeda; Osamu Sakurai; Tsutomu Miyake; Rie Tsubota; Jyunko Okabe; Masataka Kuroda; Yutaka Hisada; Tetsuya Yanagida; Hikaru Yoneda; Yukihito Tsukumo; Shin Tokunaga; Takehisa Kawata; Rikiya Ohashi; Hajime Fukuda; Koki Kojima; Ayako Kannami; Takayuki Kifuji; Naoya Sato; Akiko Idei; Taku Iguchi; Tetsuya Sakairi; Yasunori Moritani
The calcium-sensing receptor (CaSR) plays an important role in sensing extracellular calcium ions and regulating parathyroid hormone secretion by parathyroid gland cells, and the receptor is a suitable target for the treatment of hyperparathyroidism. Cinacalcet hydrochloride is a representative CaSR agonist which widely used for the hyperparathyroidism. However, it has several issues to clinical use, such as nausea/vomiting and strong inhibition of CYP2D6. We tried to improve these issues of cinacalcet for a new pharmaceutical agent as a preferable CaSR agonist. Optimization from cinacalcet resulted in the identification of pyrrolidine compounds and successfully led to the discovery of evocalcet as an oral allosteric CaSR agonist. Evocalcet, which exhibited highly favorable profiles such as CaSR agonistic activity and good DMPK profiles, will provide a novel therapeutic option for secondary hyperparathyroidism.
Archive | 2006
Yasunori Moritani; Kimihiro Shirai; Mariko Oi
Archive | 2006
Yasunori Moritani; Ritsuo Imashiro; Atsushi Sato
Archive | 2005
Yasunori Moritani; Shigeru Furukubo; Yasunori Tsuboi; Chieko Okagaki; Akira Oku; Naomitsu Hirano
Archive | 2003
Masami Takahashi; Tsutomu Miyake; Yasunori Moritani; Hidetoshi Asai; Taketoshi Ishii; Rikako Kono
Organic Process Research & Development | 2014
Takafumi Yamagami; Noriaki Moriyama; Masahiro Kyuhara; Atsushi Moroda; Takeshi Uemura; Hiroaki Matsumae; Yasunori Moritani; Isao Inoue
Archive | 2007
Kouichi Tanimoto; Mariko Oi; Yasunori Tsuboi; Yasunori Moritani
Archive | 2006
Yasunori Moritani; Kimihiro Shirai; Mariko Oi
Archive | 2005
Yasunori Moritani; Shigeru Furukubu; Yasunori Tsuboi; Chieko Okagaki; Akira Oku; Naomitsu Hirano
European Journal of Organic Chemistry | 2013
Takafumi Yamagami; Masanori Hatsuda; Masayuki Utsugi; Ryo Kobayashi; Yasunori Moritani