Yasuyo Shintani

Intravesical instillation therapy with bacillus Calmette-Guérin for superficial bladder cancer : Study of the mechanism of bacillus Calmette-Guérin immunotherapy

Aim:  In order to clarify the initial step of the mechanism by which bacillus Calmette‐Guérin (BCG) exhibits antitumor activity via the immune response induced in the bladder submucosa after intravesical BCG therapy for human bladder cancer, various cytokines secreted in the urine after BCG instillation were measured.

Insulin resistance increases the risk of urinary stone formation in a rat model of metabolic syndrome

To investigate the association between metabolic syndrome and urinary stone disease, and whether insulin resistance associated with adiposity affects the risk of urinary stone formation, using a rat model of metabolic syndrome.

PSA at postoperative three months can predict biochemical recurrence in patients with pathological T3 prostate cancer following radical prostatectomy

Objectives:  To identify the prognostic factors and determine which pT3 prostate cancer patients can be safely followed up after surgery without any adjuvant treatment.

Applicability of blunt renal trauma classification of Japanese Association for the Surgery of Trauma (JAST)

Objectives:  The Japanese Association for the Surgery of Trauma (JAST) classification is widely applied to select strategies in the treatment of blunt renal trauma in Japan. We retrospectively investigated the applicability of the JAST classification.

THE FEASIBILITY AND USEFULNESS OF JAPAN ASSOCIATION FOR THE SURGERY OF TRAUMA (JAST) CLASSIFICATION FOR BLUNT RENAL TRAUMA

RESULTS: The average follow-up was 50 months (range 12 to 132 months). The stricture etiology was catheter in 20 (32.3%) cases, unknown in 19 (32.3%), instrumentation in 17 (27.4%), trauma in 4 (6.5%), radiotherapy in 1 (1.6%) and infection in 1 (1.6%). Stricture length was: 4- 6 cm in 13 (21%), 3-<4 cm in 10 (16.1%), 2-<3 cm in 8 (12.9%), 1<2cm in 2 (3.2%). Fifty-one patients (82.2%) underwent dilation (12.9%), internal urethrotomy (17.7%), urethroplasty (4.8%) or multiple treatments (46.9%) before referral to our center. Out of 62 cases, 47 (75.8%) were successful and 15 (24.2%) failures. Out of 18 cases that underwent one-stage dartos

QUALITY OF LIFE ANALYSIS OF PATIENTS WHO UNDERWENT HIGH DOSE RATE BRACHYTHERAPY WITH EXTERNAL BEAM RADIOTHERAPY (HDR+EBRT) COMPARING WITH THOSE WHO HAD RETROPUBIC RADICAL PROSTATECTOMY (RRP)

The mean age of BT and RP treated patients was 68 and 64 years. 71,7% (n=620) of RP treated patients had non-nerve-sparing surgery. 89,3% (n=303) and 90,6% (n=770) of the BT and RP treated patients had clinical tumor stage of cT1a-2b. Significant better results in concern of increased voiding frequency (BT 67,8% vs. RP 60,4%), nocturia (BT 43,7% vs. RP 28,9%) and urge symptoms (BT 47,4% vs. RP 36,4%) were recognized at the RP treated group. Significant better results in term of incontinence was achieved in the BT group (BT 11,6% vs. RP 15,6%), but interestingly the group with nerve sparing RP showed almost similar results to BT (BT 11,6% and nerve-sparing RP 11,2%). Absence of erections was reported by 43% of the BT, 85% of RP without nerve sparing, 45% of RP with unilateral nerve sparing and 38% of the RP with bilateral nerve sparing. CONCLUSIONS: In regards to functional outcome BT causes significant higher rates of irritative voiding symptoms. However continence and Preservation of erectile function seems superior in BT compared to RP patients without nerve sparing. Nevertheless differences became minor or insignificant in RP with bilateral nerve sparing.