Yasuyuki Shimoyama

Development and evaluation of FSSG: frequency scale for the symptoms of GERD.

BackgroundThe aim of this study was to produce a simplified questionnaire for evaluation of the symptoms of gastroesophageal reflux disease (GERD).MethodsA total of 124 patients with an endoscopic diagnosis of GERD completed a 50-part questionnaire, requiring only “yes” or “no” answers, that covered various symptoms related to the upper gastrointestinal tract, as well as psychosomatic symptoms. The 12 questions to which patients most often answered “yes” were selected, and were assigned scores (never = 0; occasionally = 1; sometimes = 2; often = 3; and always = 4) to produce a frequency scale for symptoms of GERD (FSSG). Sensitivity, specificity, and accuracy of the FSSG questionnaire were evaluated in another group of patients with GERD and non-GERD. The usefulness of this questionnaire was evaluated in 26 other GERD patients who were treated with proton pump inhibitors for 8 weeks.ResultsWhen the cutoff score was set at 8 points, the FSSG showed a sensitivity of 62%, a specificity of 59%, and an accuracy of 60%, whereas a cutoff score of 10 points altered these values to 55%, 69%, and 63%. The score obtained using the questionnaire correlated well with the extent of endoscopic improvement in patients with mild or severe GERD.ConclusionsThis new questionnaire is useful for the objective evaluation of symptoms in GERD patients.

Association between reflux oesophagitis and features of the metabolic syndrome in Japan

Background  There have been many reports about the relationship between reflux oesophagitis and obesity, but not the metabolic syndrome.

Comparison of endoscopic findings with symptom assessment systems (FSSG and QUEST) for gastroesophageal reflux disease in Japanese centres

Background and Aim:  We compared endoscopic findings of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), a written questionnaire developed in Japan, to that for the questionnaire for the diagnosis of reflux esophagitis (QUEST) for the diagnosis of reflux esophagitis.

Monosodium l-glutamate added to a high-energy, high-protein liquid diet promotes gastric emptying

BACKGROUND Free glutamate activates taste receptors on nerves in the oral cavity to elicit a unique taste known as umami. Recently, umami taste receptors were also found in the gastric mucosa. Although reports suggest that mucosal receptors may respond to free glutamate to modulate gastric function, no evidence of any effect on gastric emptying has been documented. OBJECTIVE We hypothesized that glutamate may act as a modulator of gastric function. We studied the effects of L-glutamate enrichment of a protein-rich liquid meal, and similar enrichment of an equicaloric carbohydrate meal or noncaloric water, on gastric emptying. DESIGN Ten healthy men were enrolled. Nine of the 10 subjects included in the study ingested all test meals with and without monosodium L-glutamate (MSG), and the remaining subject ingested only the protein-rich meals with and without MSG. All experimental and control liquid meals included [1-(13)C]sodium acetate as a tracer. After a test meal or water was ingested, (13)C breath tests were performed to estimate gastric emptying. RESULTS MSG enrichment not only resulted in a significant decrease in the mathematically simulated half-excretion (emptying) time of a protein-rich meal, but also increased the area under the curve (%dose/h) significantly. In contrast, MSG had no significant effect on the gastric emptying of a carbohydrate meal or a noncaloric water meal. CONCLUSIONS Enrichment with MSG facilitated gastric emptying of a protein-rich meal exclusively, which suggests that free glutamate is important for protein digestion and may be helpful in the management of delayed gastric emptying.

Mechanism of gastroesophageal reflux in patients with obstructive sleep apnea syndrome.

Background  It has been reported that the prevalence of gastroesophageal reflux (GER) disease is high in patients with obstructive sleep apnea (OSA). End‐inspiratory intra‐esophageal pressure decreases progressively during OSA, which has been thought to facilitate GER in OSA patients. The aim of our study was to clarify the mechanisms of GER during sleep (sleep‐GER) in OSA patients.

High-viscosity liquid meal accelerates gastric emptying.

Abstract  Adding pectin to an elemental formula increases its viscosity through gelatinization, thus presumably preventing gastro‐oesophageal reflux and aspiration pneumonia. We investigated the influence of the viscosity of an elemental formula on gastric emptying. Eleven healthy volunteers underwent three tests at intervals of >1 week. After fasting for >8 h, each subject received a test meal (enteral nutrition solution, enteral solution plus pectin, or water). Then gastric emptying (continuous 13C breath test), gastro‐oesophageal intraluminal pressures, oesophageal pH, and blood levels of glucose, insulin and gastrin were all measured simultaneously. The gastric emptying coefficient was significantly increased by adding pectin to enteral nutrition (3.01 ± 0.10 vs 2.78 ± 0.10, mean ± SE, P < 0.05). The antral motility index was also significantly higher with pectin than without at 45–60 min and 60–75 min after the test meal (526 ± 237 vs 6.5 ± 4.6 mmHg s−1 and 448 ± 173 vs 2.3 ± 2.3 mmHg s−1 respectively; P < 0.05). Plasma glucose was significantly higher with pectin than without it at 60 min after ingestion (141.5 ± 6.03 vs 125.8 ± 4.69 μm mL−1, P < 0.05). In healthy individuals, pectin increased the viscosity of enteral nutrition and accelerated gastric emptying.

Size of hiatus hernia correlates with severity of kyphosis, not with obesity, in elderly Japanese women.

Goals To investigate whether there is a relationship between hiatus hernia (HH) and kyphosis or obesity in elderly Japanese persons. Background The causes of HH in the elderly are unclear. Study We enrolled 147 consecutive patients aged over 50 years in this study. Endoscopic assessment of the size of HH was performed by using a modified Makuuchi classification with grades from 1 (no HH) to 4 (>3 cm). The gastroesophageal flap valve (GEFV) was also graded from I to IV. Kyphosis was evaluated from a lateral photograph by measuring the modified Cobb angle (CA) and calculating the kyphosis index (KI). Body mass index (BMI) was used to evaluate obesity. Results In women, there were significant differences of both the CA (analysis of variance, P<0.0001) and KI (Kruskal-Wallis test, P<0.01) between each grade of HH. Differences of the CA (P<0.001) and KI (P<0.001) were also seen between the grades of GEFV. None of these differences were detected in men. In women, the CA (r=0.556, P<0.0001) and KI (P<0.0001) were positively correlated with age, but this was not so in men. Neither sex showed an association between BMI and the grade of either HH or GEFV. However, there was a weak negative correlation between age and BMI in women (r=−0.223, P<0.05) and men (r=−0.334, P<0.05). Conclusions The size of HH is associated with the severity of kyphosis, not with obesity, in elderly Japanese women. Age is a risk factor for both kyphosis and HH.

Diagnosis of gastroesophageal reflux disease using a new questionnaire

Background and Aim: An early and accurate evaluation by a general practitioner is needed to screen out non‐gastroesophageal reflux disease (GERD) patients. A recent questionnaire (QUEST) highlighted problems with specificity and complexity, so the aim of the present study was to design a simplified questionnaire.

Rapid gastric emptying, rather than delayed gastric emptying, might provoke functional dyspepsia

It has been suggested that there could be three possible mechanisms of gastric dysfunction in patients with FD: (i) delayed gastric emptying, (ii) impaired gastric accommodation of food intake, and (iii) hypersensitivity to gastric distention. Postprandial fullness seems to be the most severe symptom in patients who report aggravation of their symptoms after meals. Therefore, it has been assumed that delayed gastric emptying and consequent prolonged antral distension could reduce hunger, increase satiety, and even cause gastric discomfort, all of which would pose a significant barrier to adequate nutrition.

Variant parameter values—as defined by the Chicago Criteria—produced by ManoScan and a new system with Unisensor catheter

Recently reported normal values for esophageal motility obtained by high‐resolution manometry (HRM) using a system with a Unisensor catheter were significantly different from those obtained by the ManoScan®, which could result in a wrong diagnosis. To clarify whether these differences were due to system or subject differences, we compared the manometric parameter values between ManoScan and a new system with a Unisensor catheter (Starlet) in the same subjects.