Yasuyuki Ushio

Synthesis of solenopsin B via stereoselective reduction of Bicyclic N,O-ketals

Abstract A new enantioselective total synthesis of (−)-solenopsin B was described starting from L-glutamic acid as an optically active natural source, in which stereoselective reduction of bicyclic N,O-ketals with DIBALH was used as the key reaction step.

Efficient reduction of acyl chlorides with zinc borohydride/N,N,N′,N′-tetramethylethylenediamine

Abstract Various acyl chlorides are efficiently reduced to the corresponding alcohols under mild conditions by treatment with zinc borohydride in the presence of N,N,N′,N′-tetramethylethylenediamine.