Yawen Zhang

Research on the Synthesis of 1,4-Dihydropyridines Under Microwave

Abstract Four 1,4-dihydropyridines were synthesized through the condensation of methyl 3-aminocrotonate with methyl acetoacetate-benzaldehydes under microwave without using solvents.

A novel chiral aliphatic–aromatic diamine promoted direct, highly enantio- and diastereoselective Michael addition of cyclohexanone to nitroolefins under solvent-free conditions

A series of new highly efficient chiral aliphatic-aromatic diamine catalysts have been designed and successfully applied to the asymmetric Michael addition of cyclohexanone with nitroolefins under solvent-free conditions without any acidic additives. The desired adducts were obtained in high yields with excellent enantio- and diastereoselectivities of syn products (up to >99% ee, >99:1 dr).

A New Chiral Catalyst for the Enantioselective Reduction of Prochiral Ketones with Borane

Abstract A new chiral β-amino alcohol, (s)-2-amino-1, 1-diphenyl-3-(2-naphthyl)-1-propanol and its use as a catalyst in the enantioselective reduction of prochiral ketones with borane were described.

(S)-2-Amino-3-(2,5-dimethylphenyl)-1,1-diphenyl-1-propanol: Synthesis and Application in Enantioselective Reduction of Prochiral Ketones

Abstract The title chiral amino alcohol 6 was prepared from (s)-3-(2,5-dimethylphenyl)-alanine methyl ester hydrochloride by its reaction with phenyl magnesium bromide. In the presence of 2 mol% of 6, the borane reduction of prochiral ketones gave optically active secondary alcohols in high yields with the ees ranged from 40.5 to 100%.