Yee-Shing Wong
Schering-Plough
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Publication
Featured researches published by Yee-Shing Wong.
Bioorganic & Medicinal Chemistry Letters | 1993
Donald Hou; Janet L. Mas; Tze-Ming Chan; Yee-Shing Wong; Martin Steinman; Andrew T. McPhail
Abstract Novel, stereoselective syntheses of (3S, 4R, 5R)-1-(allyloxycarbonyl)methyl-3-[1-hydroxyethyl]-4-β-naphthoxy(thiocarbonyl)thio-2-azetidinone (13) and (3S, 4R, 5R, 3′S, 4′R, 5′R)-4,4′-dithio-bis-1-(allyloxy-carbonyl)methyl-3-[-1-hydroxyethyl]-2-azetidinone (22), key intermediates in the synthesis of the penem antibiotic Sch 34343, were developed starting from readily available 6-aminopenicillanic acid. Advantages of these routes include 1) the highly stereospecific introduction of the hydroxyethyl sidechain with the desired (R)-configuration and 2) the retention of the sulfur of the starting material.
Archive | 1997
Guang-Zhong Wu; Xing Chen; Yee-Shing Wong; Doris P. Schumacher; Martin Steinman
Journal of Medicinal Chemistry | 1973
Martin Steinman; John G. Topliss; Robert Alekel; Yee-Shing Wong; Eunice E. York
Organic Process Research & Development | 1997
Guang-Zhong Wu; Yee-Shing Wong; Martin Steinman; Wanda Tormos; Doris P. Schumacher; and George M. Love; Bruce Shutts
Archive | 1996
Guang-Zhong Wu; Xing Chen; Yee-Shing Wong; Doris P. Schumacher; Martin Steinman
Archive | 2001
Marc Poirier; Yee-Shing Wong; George G. Wu
Archive | 1998
Xing Chen; Marc Poirier; Yee-Shing Wong; Guang-Zhong Wu
Archive | 1994
Guang-Zhong Wu; Martin Steinman; Yee-Shing Wong
Tetrahedron Letters | 1974
Martin Steinman; Yee-Shing Wong
Archive | 1990
Donald Hou; Yee-Shing Wong; Dinesh Gala; Martin Steinman