Yeo Hyang Kim
Kyungpook National University
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Featured researches published by Yeo Hyang Kim.
Pediatric Gastroenterology, Hepatology & Nutrition | 2013
Suk Jin Hong; Yeo Hyang Kim; Byung-Ho Choe; Hyo Jung Park; Won Young Tak; Young-Oh Kweon
Purpose To identify the predictive factors of long-term therapeutic response or resistance to lamivudine treatment in children and adolescents with chronic hepatitis B. Methods Eighty one children and adolescents with chronic hepatitis B were included, who received lamivudine treatment for at least 6 months. Their condition was monitored for at least 12 months (12-88 months) thereafter. Twenty one (25.9%) were preschool children (age≤6). For patients who had developed HBeAg seroconversion or breakthrough, univariate and multivariate analyses were used to identify the effects of age, gender, pretreatment alanine aminotransferase (ALT) and hepatitis B virus DNA levels. Results HBeAg seroconversion occurred in 49 (60.5%) of the 81 patients after the initiation of the lamivudine therapy. In 65 patients whom were monitored for over 24 months, the seroconversion rate was significantly higher in younger patients (p=0.040), especially in those patients of preschool age (age≤6, p=0.031). The seroconversion rate was significantly higher in higher pretreatment ALT (p=0.003). The breakthrough occurred in 21 (25.9%) of the 81. The breakthrough rate was lower in younger aged patients (age≤6), and with higher pretreatment ALT levels, but no significant difference. Conclusion Younger age is a good predictor of HBeAg seroconversion in children with long-term lamivudine treatment as well as high pretreatment ALT levels.
Korean Circulation Journal | 2018
Bo Geum Choi; Sukyung Hwang; Jung Eun Kwon; Yeo Hyang Kim
Background and Objectives The purpose of the present study was to investigate the advantages and disadvantages of verifying genetic abnormalities using array comparative genomic hybridization (a-CGH) immediately after diagnosis of congenital heart disease (CHD). Methods Among neonates under the age of 28 days who underwent echocardiography from January 1, 2014 to April 30, 2016, neonates whose chromosomal and genomic abnormalities were tested using a-CGH in cases of an abnormal finding on echocardiography were enrolled. Results Of the 166 patients diagnosed with CHD, 81 underwent a-CGH and 11 patients (11/81, 13.5%) had abnormal findings on a-CGH. 22q11.2 deletion syndrome was the most common (4/11, 36.4%). On the first a-CGH, 4 patients were negative (4/81, 5%). Three of them were finally diagnosed with Williams syndrome using fluorescent in situ hybridization (FISH), 1 patient was diagnosed with Noonan syndrome through exome sequencing. All of them exhibited diffuse pulmonary artery branch hypoplasia, as well as increased velocity of blood flow, on repeated echocardiography. Five patients started rehabilitation therapy at mean 6 months old age in outpatient clinics and epilepsy was diagnosed in 2 patients. Parents of 2 patients (22q11.2 deletion syndrome and Patau syndrome) refused treatment due to the anticipated prognosis. Conclusions Screening tests for genetic abnormalities using a-CGH in neonates with CHD has the advantage of early diagnosis of genetic abnormality during the neonatal period in which there is no obvious symptom of genetic abnormality. However, there are disadvantages that some genetic abnormalities cannot be identified on a-CGH.
Korean Journal of Pediatrics | 2016
Jung Ok Kim; Yeo Hyang Kim; Myung Chul Hyun
Purpose We evaluated the characteristics of patients with Kawasaki disease (KD) who presented with only fever and cervical lymphadenopathy on admission, and compared them with the characteristics of those who presented with typical features but no cervical lymphadenopathy. Methods We enrolled 98 patients diagnosed with KD. Thirteen patients had only fever and cervical lymphadenopathy on the day of admission (group 1), 31 had typical features with cervical lymphadenopathy (group 2), and 54 had typical features without cervical lymphadenopathy (group 3). Results The mean age (4.3±2.1 years) and duration of fever (7.5±3.6 days) before the first intravenous immunoglobulin (IVIG) administration were highest in group 1 (P=0.001). Moreover, this group showed higher white blood cell and neutrophil counts, and lower lymphocyte counts after the first IVIG administration as compared to the other groups (P=0.001, P=0.001, and P=0.003, respectively). Group 1 also had a longer duration of hospitalization and higher frequency of second-line treatment as compared to groups 2 and 3 (group 1 vs. group 2, P=0.000 and P=0.024; group 1 vs. group 3, P=0.000 and P=0.007). A coronary artery z score of >2.5 was frequently observed in group 1 than in group 3 (P=0.008). Conclusion KD should be suspected in children who are unresponsive to antibiotics and have prolonged fever and cervical lymphadenopathy, which indicates that KD is associated with the likelihood of requiring second-line treatment and risk of developing coronary artery dilatation.
Journal of Cardiovascular Ultrasound | 2015
Hyungseop Kim; Yeo Hyang Kim
Persistent truncus arteriosus categories associated with different natural histories and various surgical approaches were reported. Although pulmonary overflow and severe heart failure are common, some patients who have hypoplastic pulmonary artery systems may show lesser symptoms of heart failure and remain in relatively stable condition. We experienced a 33-year-old woman with uncorrected type II persistent truncus arteriosus who presented with cyanosis rather than congestive heart failure, and are presenting her images.
Journal of Korean Medical Science | 2015
Hee Joung Choi; Yeo Hyang Kim
We investigated the clinical presentations, diagnostic and therapeutic modalities, and prognosis from follow-up of infants with apparent life-threatening events (ALTE). In addition, the relationship between the clinical characteristics of patients and significant intervention scores was analyzed. We enrolled patients younger than 12 months who were diagnosed with ALTE from January 2005 to December 2012. There were 29 ALTE infants with a peak incidence of age younger than 1 month (48.3%). The most common symptoms for ALTE diagnosis were apnea (69.0%) and color change (58.6%). Eleven patients appeared normal upon arrival at hospital but 2 patients required cardiopulmonary resuscitation during the initial ALTE. The most common ALTE cause was respiratory disease, including respiratory infection and upper airway anomalies (44.8%). There were 20 cases of repeat ALTE and 2 cases of death during hospitalization. Four patients (15.4%) experienced recurrence of ALTE after discharge and 4 patients (15.4%) showed developmental abnormalities during the follow-up period. The patients with ALTE during sleep had lower significant intervention scores (P=0.015) compared to patients with ALTE during wakefulness and patients with previous respiratory symptoms had higher significant intervention scores (P=0.013) than those without previous respiratory symptoms. Although not statistically significant, there was a weak positive correlation between the patients total ALTE criteria and total significant intervention score (Fig. 2, r=0.330, P=0.080). We recommend that all ALTE infants undergo inpatient observation and evaluations with at least 24 hr of cardiorespiratory monitoring, and should follow up at least within a month after discharge. Graphical Abstract
Korean Journal of Pediatrics | 2018
Tae Kyoung Jo; Hyo Rim Suh; Bo Geum Choi; Jung Eun Kwon; Hanna Jung; Young Ok Lee; Joon Yong Cho; Yeo Hyang Kim
Purpose The present study aimed to evaluate progression and prognosis according to the palliation method used in neonates and early infants aged 3 months or younger who were diagnosed with pulmonary atresia with ventricular septal defect (PA VSD) or tetralogy of Fallot (TOF) with severe pulmonary stenosis (PS) in a single tertiary hospital over a period of 12 years. Methods Twenty with PA VSD and 9 with TOF and severe PS needed initial palliation. Reintervention after initial palliation, complete repair, and progress were reviewed retrospectively. Results Among 29 patients, 14 patients underwent right ventricle to pulmonary artery (RV-PA) connection, 11 palliative BT shunt, 2 central shunt, and 2 ductal stent insertion. Median age at the initial palliation was 13 days (1–98 days). Additional procedure for pulmonary blood flow was required in 5 patients; 4 additional BT shunt operations and 1 RV-PA connection. There were 2 early deaths among patients with RV-PA connection, one from RV failure and the other from severe infection. Finally, 25 patients (86%) had a complete repair. Median age of total correction was 12 months (range, 2–31 months). At last follow-up, 2 patients had required reintervention after total correction; 1 conduit replacement and 1 right ventricular outflow tract (RVOT) patch enlargements. Conclusion For initial palliation of patients with PA VSD or TOF with severe PS, not only shunt operation but also RV-PA connection approach can provide an acceptable outcome. To select the most proper surgical strategy, we recommend thorough evaluation of cardiac anomalies such as RVOT and PA morphologies and consideration of the patient’s condition.
Biomedical Journal of Scientific and Technical Research | 2018
Jung Un Shinn; Hyun Hwa Cha; Yeo Hyang Kim; Won Joon Seong
Complete transposition of the great arteries (d-TGA) accounting for 5 % of all congenital heart disease (CHD) is one of the most common cyanotic CHDs. Advances in congenital cardiology and surgery improve the prognosis in patients with TGA, nowadays women who survived the disease are entering the child bearing ages. Although, arterial switch operation has been becoming the standard treatment for TGA, atrial switch operation (ASO) was performed till past decades. Right ventricle (RV) becomes to be in charge of systemic circulation in patients with ASO. RV cannot sustain the demands of the systemic circulation and gradually decrease the function. Recently, we have experienced a pregnancy in a patient with congenital TGA treated with ASO. She uneventfully delivered a male neonate weighing of 3100 grams at 38 weeks of gestation. However, she developed the sign of heart failure on four days after delivery. We successfully managed her with administration of oxygen, diuretics and angiotensin converting enzyme (ACE) inhibitor. Herein, we report this case with a review of literatures. Abbreviations: CHD: Congenital Heart Diseases; ASO: Atrial Switch Operation; RV: Right Ventricle; ACE: Angiotensin Converting Enzyme; SVR: Systemic Vascular Resistance; TR: Tricuspid Regurgitation; NYHA: Heart Association; MRI: Magnetic Resonance Imaging; USG: Obstetrical Ultrasonography; FS: Fractional Shortening; ICU: Intensive care unit; CSE: Combined Spinal and Epidural; PACU: Post Anesthesia Care Unit; SVC: Superior Vena Cava; ICV: Inferior Vena Cava Biomedical Journal of Scientific & Technical Research Volume 7Issue 3: 2018 Cite this article: Hyun Hwa C, Jung Un S, Yeo Hyang K, Won Joon S. Pregnancy in a Patient with Congenital Complete Transposition of Great Arteries after Atrial Switch Operation: A Case Report with a Review of Literatures. Biomed J Sci&Tech Res 7(3)2018. BJSTR. MS.ID.001491. DOI: 10.26717/ BJSTR.2018.07.001491. 2/3 of heart failure (Figure 2) and performed carefully obstetrical care. 2D echocardiography performed at 373/7 weeks revealed that decreased RV function compared to previous study (FS 22%). There was no significant event during antepartum period. We discussed about the mode of delivery with the pediatric cardiologist and obstetrical anesthesiologist. We thought that elective delivery would be better; therefore, we decided to perform cesarean delivery at 381/7 weeks of gestation. Figure 1: Maternal 2D echocardiography showed that functional fraction of the maternal right ventricle was 35%. Figure 2: he levels of maternal NT-Pro-BNP during antepartum period. They remained stable during the pregnancy. A male neonate was born weighing 3100 gram with Apgar score 8 and 9 in 1-minute and 5-minutes. The anesthesiologist chose combined spinal and epidural (CSE) method to avoid a sudden change in blood pressure. An arterial cannulation was established at her right radial artery for close monitoring of blood pressure and continuous cardiac output. Her blood pressure maintained the range of 110-120/69-85 mmHg during systolic and diastolic period, respectively. Also, continuous electrocardiogram showed normal sinus rhythm without arrhythmia at operative room and post anesthesia care unit (PACU). However, her postoperative NTproBNP levels started to increase abruptly on 3rd day after delivery (Figure 3). The level of NT-proBNP more increased on 4th day after delivery and she began to complain chest tightness, dyspnea and sweating. We decided to admit her in the intensive care unit (ICU) and started applying of oxygen, administering ACE inhibitor (5 mg/day) and diuretics, of which start dose was furosemide 20mg/ day intravenously followed by 10 mg twice/day and 5mg/day. Her symptom was improved and NT-proBNP level was decreased to normal value. She was discharged with good condition on 8th day after delivery and will undergo cardiac MRI near soon. Figure 3: The levels of maternal NT-Pro-BNP during postpartum period. Her postoperative NT-proBNP levels started to increase abruptly on 3rd day after delivery.
Korean Journal of Pediatrics | 2017
Na Hyun Lee; Hee Joung Choi; Yeo Hyang Kim
Purpose The aims of this study were to compare serum procalcitonin (PCT) levels between febrile children with Kawasaki disease (KD) and those with bacterial or viral infections, and assess the clinical usefulness of PCT level in predicting KD. Methods Serum PCT levels were examined in febrile pediatric patients admitted between August 2013 and August 2014. The patients were divided into 3 groups as follows: 49 with KD, 111 with viral infections, and 24 with bacterial infections. Results The mean PCT level in the KD group was significantly lower than that in the bacterial infection group (0.82±1.73 ng/mL vs. 3.11±6.10 ng/mL, P=0.002) and insignificantly different from that in the viral infection group (0.23±0.34 ng/mL,P=0.457). The mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level in the KD group were significantly higher than those in the viral and bacterial infection groups (P<0.001 and P<0.001 for ESR, P<0.001 and P=0.005 for CRP, respectively). The proportion of patients in the KD group with PCT levels of >1.0 ng/mL was significantly higher in the nonresponders to the initial intravenous immunoglobulin treatment than in the responders (36% vs. 8%, P=0.01). Conclusion PCT levels may help to differentiate KD from bacterial infections. A combination of disease markers, including ESR, CRP, and PCT, may be useful for differentiating between KD and viral/bacterial infections.
Korean Journal of Pediatrics | 2017
Da Eun Roh; Sook-Hyun Park; Hee Joung Choi; Yeo Hyang Kim
Purpose The aim of this study was to evaluate whether infants with rhinovirus (RV) infection-induced wheezing and those with respiratory syncytial virus (RSV) infection-induced wheezing have different cytokine profiles in the acute stage. Methods Of the infants with lower respiratory tract infection (LRTI) between September 2011 and May 2012, 88 were confirmed using reverse transcription polymerase chain reaction and hospitalized. Systemic interferon-gamma (IFN-γ), interleukin (IL)-2, IL-12, IL-4, IL-5, IL-13, and Treg-type cytokine (IL-10) responses were examined with multiplex assay using acute phase serum samples. Results Of the 88 patients, 38 had an RV infection (RV group) and 50 had an RSV infection (RSV group). In the RV group, the IFN-γ and IL-10 concentrations were higher in the patients with than in the patients without wheezing (P=0.022 and P=0.007, respectively). In the RSV group, the differences in IFN-γ and IL-10 concentrations did not reach statistical significance between the patients with and the patients without wheezing (P=0.105 and P=0.965, respectively). The IFN-γ and IL-10 concentrations were not significantly different between the RV group with wheezing and the RSV group with wheezing (P=0.155 and P=0.801, respectively), in contrast to the significant difference between the RV group without wheezing and the RSV group without wheezing (P=0.019 and P=0.035, respectively). Conclusion In comparison with RSV-induced LRTI, RV-induced LRTI combined with wheezing showed similar IFN-γ and IL-10 levels, which may have an important regulatory function.
Korean Journal of Pediatrics | 2015
Sun Young Park; Young Hyun Kim; Yeo Hyang Kim; Myung Chul Hyun; Young Hwan Lee
Purpose Kawasaki disease involves acute febrile systemic vasculitis that can cause a variety of symptoms by affecting various organs. Here, we aimed to evaluate the prevalence, causes, and prognosis of sensorineural hearing loss (SNHL) occurring in children with Kawasaki disease. Methods Patients who were diagnosed with Kawasaki disease and received inpatient treatment in the Pediatrics Department at one of three university hospitals in Daegu city from February 2012 to September 2012 were enrolled in the study. The clinical features, hematological results, echocardiography results, audiometry results, and aspirin and salicylic acid serum levels of the patients were evaluated. Results Of the 59 children enrolled in the study, three showed mild bilateral SNHL on audiometry tests conducted after 48 hours of defervescence; these patients demonstrated normal patterns of recovery on follow-up tests 8 weeks later. Aspirin serum levels were significantly higher in the SNHL group after 48 hours of afebrile condition with high dose aspirin intake (P=0.034). However, no significant differences were found in other laboratory tests or for fever duration (P>0.05). Upon echocardiography, coronary artery abnormality was observed in 9 cases, but none of these patients showed hearing loss. Conclusion The results indicate that SNHL in children with Kawasaki disease might occur during treatment of the acute phase; this SNHL usually involves mild bilateral hearing loss and recovers naturally. However, this study suggests that determination of the causes and clinical implications of hearing loss in Kawasaki disease requires long-term follow-up studies with more cases.