Yeriyur Basavaiah Basavaraju

Synthesis and biological screening of pyrazole moiety containing analogs of podophyllotoxin

The pyrazole moiety containing analogs of podophyllotoxin as potential antimitotic agents were synthesized in five step reactions via chalcone route. The first step is the synthesis of chalcone (2a–d) by the reaction of substituted acetophenones with p-tolualdehyde in the presence of sodium hydroxide in water–ethanol mixture. The cyclopropyl ketones (3a–d) were prepared by the reaction of chalcones (2a–d) with trimethylsulfoxonium iodide (TMSOI) in dry DMSO. The key intermediate tetralones (4a–d) were prepared by the intramolecular cyclization reaction of cyclopropyl ketones (3a–d) in the presence of anhyd. stannic chloride and acetic anhydride in dry dichloromethane. These compounds (4a–d) on formylation give substituted hydroxylmethylene tetralones (5a–d). Further, pyrazole moiety containing analogs of podophyllotoxin (6a–d) were synthesized in high yields by the condensation of hydroxylmethylene tetralones (5a–d) with hydrazine hydrate in absolute ethanol. The structures of the synthesized compounds were confirmed by spectral and elemental analysis data. The synthesized compounds were also screened for their antimitotic activity. It is noteworthy that compounds 6d possessed excellent antimitotic activity, 6b and 6c showed considerable activity, and remaining 6a possessed least activity. Compound 6d was immense to show high antibacterial and antifungal activity against all bacterial and fungal strains compared with standard chloramphenicol and nystatin, respectively.

1-(3,4-Di­meth­oxy­phen­yl)-3-phenyl­prop-2-en-1-one

In the title compound, C17H16O3, the dihedral angle between the mean planes of the benzene rings is 57.1 (1)°. The mean plane of the ketone group is twisted by 10.0 (5)° from that of the dimethoxyphenyl ring. The two dimethoxyphenyl groups are twisted slighly from the mean plane of the phenyl ring, with C—O—C—C torsion angles of 6.4 (2) and −7.9 (2)° [r.m.s. deviations = 0.15 (3) and 0.18 (3) Å for the two methoxy C atoms]. In the crystal, weak centroid–centroid π–π stacking interactions, with intercentroid distances of 3.8939 (11) and 3.9430 (10) Å are observed.

4-Methoxy-3-methylbenzophenone

The molecule of the title compound,

Cobalt(II) catalyzed dehydration of aldoximes: A highly efficient practical procedure for the synthesis of nitriles

C_1_5H_1_4O_2

Cobalt(II) acetylacetonate catalyzed Friedel–Crafts acylation of anisole, thioanisole, and toluene

, is non-planar and the planes of the benzene rings intersect at an angle of

Synthesis and characterization of novel benzo[d][1,3]dioxole gathered pyrazole derivatives and their antimicrobial evaluation

459.8 (1)^{\circ}

Synthesis and characterization of diaza analogues of podophyllotoxin

. The crystal structure exhibits a significant short intermolecular

Synthesis and Crystal Structure of a Chalcone Analog: (2E)-3-(3,4-Dimethoxyphenyl)-1-(3-methyl-4-methoxyphenyl)prop-2-en-1-one

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3‐Chloro‐4‐hydr­oxy‐4′‐methyl­benzophenone

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Synthetic study on chalcone and their dihydropyrimidinone and dihydropyrimidinethione derivatives

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