Yesim Acar

Autoimmune complications associated with hepatitis A virus infection in children.

Hepatitis A virus infection is usually a self-limited disease during childhood. Autoimmune manifestations are rarely reported among patients. We describe two children with acute hepatitis A infection who developed immune thrombocytopenia and hepatic venous thrombosis during the course of acute infection. Antiphospholipid antibodies were increased in both of them during the thrombocytopenic and thrombotic complications and decreased during the resolution of these events.

Thrombotic and thrombocytopenic complications secondary to hepatitis A infection in children.

Thrombotic and thrombocytopenic complications secondary to hepatitis A infection in children

A Rare Case of Cholestasis: Arthrogryposis, Renal Tubular Disorder and Cholestasis Syndrome

Arthrogryposis, renal tubular dysfunction, cholestasis (ARC) syndrome was originally described in 1973 by LutzRichner and Landolt (1) severe growth retardation, ichthyosis, recurrent febrile disease, platelet abnormalities, sensorineural hearing loss, hypotonia and corpus callosum dysgenesis were later included as further features of the syndrome (1,2). This multisystemic disease due to an autosomal recessive hereditary transmission occurs as a result of VPS33B or VIPAR gene mutations (3,4). Most of the patients are lost during the first year of their lives due to dehydration, acidosis, sepsis and particularly profuse bleeding due to diagnostic invasive interventions (1,2,4). We present here a case of ARC syndrome diagnosed by genetic analysis. Case Report