Yewen Fang

Ligand-Free CuI-Catalyzed Highly Efficient Intramolecular S-Vinylation of Thiols with Vinyl Chlorides and Bromides

With CuI as the catalyst and K(3)PO(4) x 3 H(2)O as the base, highly efficient intramolecular S-vinylation of thiols with vinyl chlorides or bromides was successfully implemented without the help of an additional ligand. Moreover, the competition experiments revealed that the 4-exo cyclization is fundamentally preferred over other modes (5-exo, 6-exo, and 6-endo) of cyclization.

Palladium-catalysed coupling of α-halo vinylphosphonate and α-phosphonovinyl sulfonate with alkylzincs: straightforward and versatile synthesis of α-alkyl vinylphosphonates

With α-(pseudo)halo vinylphosphonate as the electrophilic coupling partner, a variety of alkyl- and benzylic zinc reagents underwent vinylation reactions to produce α-alkyl vinylphosphonates. This unprecedented Pd-catalysed Negishi coupling features mild reaction conditions, high functional group tolerance, broad substrate scope, retention of the olefin geometry, and easy gram-scale synthesis.