Yi Huang

Hepatitis E virus seroprevalence and molecular study among blood donors in China

The risk of hepatitis E virus (HEV) infection from blood transfusion has aroused increasing concern in many countries. The aim of this study was to analyze the potential risk of HEV infection through blood transfusion in China.

Prevalence, incidence, and residual risks for transfusion‐transmitted human immunodeficiency virus Types 1 and 2 infection among Chinese blood donors

There are little data on human immunodeficiency virus (HIV) prevalence, incidence, or residual risks for transfusion‐transmitted HIV infection among Chinese blood donors.

The human immunodeficiency virus-1 genotype diversity and drug resistance mutations profile of volunteer blood donors from Chinese blood centers.

BACKGROUND: The global human immunodeficiency virus (HIV)‐1 epidemic is becoming increasingly diverse and complex. Molecular epidemiologic characteristics were studied for HIV‐1–infected blood donors from five Chinese regions to determine genotype diversity and drug resistance mutations (DRMs) profile.

Hepatitis B virus nucleic acid testing in Chinese blood donors with normal and elevated alanine aminotransferase

BACKGROUND: Nucleic acid testing (NAT) is currently not a routine donor test in China. The aim of this study was to evaluate the current residual risk of hepatitis B virus (HBV) transmission and the value of ALT testing in preventing HBV infection.

Who donates blood at five ethnically and geographically diverse blood centers in China in 2008.

BACKGROUND: In China recruitment and retention of sufficient numbers of safe blood donors continues to be a challenge. Understanding who donates blood, particularly those who donate larger (>200u2003mL) whole blood (WB) units, will help blood centers to target more effective recruitment and retention strategies.

Impact of the May 12, 2008, earthquake on blood donations across five Chinese blood centers

BACKGROUND: On May 12, 2008, a severe earthquake struck Chinas Sichuan Province. The nationwide outpouring of charity resulted in a surge of subsequent blood donations. The quantity and quality of these donations were examined in comparison with routine donations.

An analysis of risk factors for human immunodeficiency virus infection among Chinese blood donors

Information regarding the risk factors for human immunodeficiency virus (HIV) infection among Chinese donors is important for understanding the trend of HIV transmission routes and for developing effective donor behavioral screening policies.

First-time donors responding to a national disaster may be an untapped resource for the blood centre

Backgroundu2002 On 12 May 2008, a severe earthquake struck Sichuan in China. Many people donated blood for the first time, leading us to question whether these donors might become repeat donors in the future. The return pattern of post‐earthquake first‐time donors (PEFTD) was compared with that of first‐time donors (FTD) in a comparable period.

The persistence of hepatitis C virus transmission risk in China despite serologic screening of blood donations

A total of 2%‐2.9% of the population in China is infected with hepatitis C virus (HCV). This study estimated the prevalence and incidence of HCV among Chinese blood donors.

Molecular epidemiological study of hepatitis B virus in blood donors from five Chinese blood centers

Although the genetic variability of hepatitis B virus (HBV) in HBV-infected patients has been extensively studied, reports on genotypes, subtypes and mutations in the S region of HBV strains from Chinese blood donors are limited. In this study, 245 blood samples from HBsAg-positive blood donors were collected from five geographically diverse blood centers in China. The S region of HBV was amplified, and the HBV genotype and subtype were determined. The amino acid sequences of the S region were aligned, and mutations related to the failure of immunization and HBsAg detection were determined. Of the 245 samples, 228 (93xa0%) were genotyped successfully. We found that genotypes B, C, D and A accounted for 58.8xa0%, 21.9xa0%, 6.6xa0% and 3.95xa0% of the isolates, respectively. The distribution of HBV antigen subtypes was as follows: adw (67.6xa0%), adr (23.3xa0%) and ayw (8.7xa0%). Mutations were present in 39 (17.1xa0%) of 228 samples in the major hydrophilic region (MHR) of the S region. This study demonstrated that HBV genotype/subtype B/adw was the most frequent strain circulating in HBV-infected Chinese blood donors, followed by C/adr. The occurrence of MHR mutants in HBV-infected blood donors and the potential failure to detect some of them in collected units poses a threat to transfusion safety.