一矢 有一

Diamox負荷99mTc-HMPAO SPECTを用いたモヤモヤ病の脳循環の評価

Diamox負荷99mTc-HMPAO SPECTを用いてモヤモヤ病患者の脳循環を評価した。対象はモヤモヤ病9例 (小児4例, 成人5例) である。安静時では9例中6例に血流低下を認めた。3例では血流低下を認めなかった。Diamoxテストは9例中6例で陽性であったが, 安静時に異常がみられなかった3例はすべて陽性であった。以上より, Diamox負荷99mTc-HMPAO SPECTはモヤモヤ病患者の脳循環の評価に有用であった。

2-デオキシ-2- [18F] フルオロ-D-グルコース (18FDG) 自動合成装置の改良

An automatic synthesis equipment for 18FDG by micro-computer control was manufactured for trial. In order to perfectly prevent a mistaken action, new methods were introduced in the hardwires and the softwares. Moreover, if a part of the control becomes out of order, only that action is changed over to manual operation immediately, and it was made so that the synthesis can be continued. By this means, the synthesis became feasible without fail.

IRMA法による血中インシュリン測定用キット“インシュリン・リアビーズII”の検討

We performed the basic and clinical evaluation of immunoradiometric assay kit for serum insulin, “INSULIN·RIABEAD®II”. The reaction time of this kit is 2.5 h, which is much shorter than that of the RIA kit for 16-24 h. In the basic examination, reproducibility of intraand inter-assay variance, dilution test and recovery test, good results were obtained in all of them. Correlation between immunoreactive insulin values measured by radioimmunoassay kit and those measured by this kit was significant (r=0.98) . In the clinical examination, immunorective insulin values of the healthy controls, a patient with insulinoma and a patient positive for antiinsulin receptor antibody were examined. In conclusion, these data indicated that this kit is very useful for measurement of the immunoreactive insulin.

IRMA法による血中インシュリン測定用キット"インシュリン・リアビーズ(R)2"の検討

We performed the basic and clinical evaluation of immunoradiometric assay kit for serum insulin, “INSULIN·RIABEAD®II”. The reaction time of this kit is 2.5 h, which is much shorter than that of the RIA kit for 16-24 h. In the basic examination, reproducibility of intraand inter-assay variance, dilution test and recovery test, good results were obtained in all of them. Correlation between immunoreactive insulin values measured by radioimmunoassay kit and those measured by this kit was significant (r=0.98) . In the clinical examination, immunorective insulin values of the healthy controls, a patient with insulinoma and a patient positive for antiinsulin receptor antibody were examined. In conclusion, these data indicated that this kit is very useful for measurement of the immunoreactive insulin.

虚血性心疾患における99mTc-Methoxy Isobutyl Isonitrile心筋SPECTの有用性

新しい心筋血流イメージング製剤の99mTc-MIBIを用いて虚血性心疾患を主体とする10例において, 運動負荷時および安静時心筋SPECTを施行し, 同時期のTl運動負荷検査と対比した。MIBI検査の撮像は投与30分後および4時間後に, またTl検査は負荷直後像および4時間後の遅延像を撮像した。MIBI像の画質は短い撮像時間にもかかわらず, Tl像に比して全例でやや鮮明か同程度であった。しかし, 安静時30分後像に肝への集積のため下後壁が判定不能であった1例が見られた。MIBI4時間後像では30分後像に見られなかった欠損部が4検査で認められ, 診断上注意が必要と思われた。MIBI運動負荷後像とTl運動負荷直後像とはよく一致していたが, MIBI安静像とTl遅延像とでは2例において所見の差異が見られた。99mTc-MIBIは心筋血流イメージング製剤として有用と思われたが, その心筋からの洗出し, およびTlとの相違については今後さらに検討が必要である。

123I-m-lodobenzylguanidineを用いた心筋SPECT

Myocardial SPECT imaging using 123I-MIBG was performed in 29 patients with cardiac disorders and compared with the results of 201Tl SPECT imaging. The areas with decreased uptake of 123I-MIBG was usually more extended than those observed with 201Tl SPECT, which was more prominent in the delayed scan than in the early scan. In the 2 patients out of 4 with hypertrophic cardiomyopathy, the distribution of 123I-MIBG and 201Tl was not matched. Namely, high uptake of 123I-MIBG was observed in the regions with low 201Tl uptake. The washout rate for 123I-MIBG was higher in the region with decreased myocardial wall motion than those with preserved wall motion.