Ying-Tung Yeh

Risk of Stroke-Associated Pneumonia With Acid-Suppressive Drugs: A Population-Based Cohort Study.

Abstract Acid-suppressive drugs, including histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), are common medications used for treating upper gastrointestinal tract disorders. However, acid-suppressive drugs have been reported to increase the risk of pneumonia in numerous disease populations. However, the relationship between acid-suppressive drugs and stroke-associated pneumonia (SAP) remains controversial. The purpose of this study was to investigate the association between acid-suppressive drug usage and pneumonia among patients with stroke by using a nationwide data set. A population-based cohort study was conducted using a data set from the Taiwanese National Health Insurance Research Database. Data on patients with new-onset stroke from 2010 to 2011 were collected. Patients with and without acid-suppressive drug usage were followed up to identify the occurrence of any type of pneumonia. We estimated the adjusted hazard ratios (HRs) by using the Cox proportional hazards model. The study cohort comprised 7965 patients with new-onset stroke. The incidence of pneumonia was 6.9% (552/7965) and more than 40% (225/552) of patients developed pneumonia within 3 months after an acute stroke. Acid-suppressive drug usage was an independent risk factor of pneumonia. The adjusted HR for the risk of pneumonia in patients with new-onset stroke using acid-suppressive drugs was 1.44 (95% confidence interval [CI] = 1.18–1.75, P < 0.01). Only PPI usage increased risk of chronic SAP (adjusted HR = 1.46, 95% CI = 1.04–2.05). Acid-suppressive drug usage was associated with a slightly increased risk of SAP. Physicians should exercise caution when prescribing acid-suppressive drugs to patients with stroke, particularly at the chronic stage.

Population-based cohort study on the risk of pneumonia in patients with non-traumatic intracranial haemorrhage who use proton pump inhibitors

Objectives This nationwide cohort study investigated the association between proton pump inhibitor (PPI) usage and the risk of pneumonia in patients with non-traumatic intracranial haemorrhage (ICH). Design Nationwide population-based cohort study. Setting Longitudinal Health Insurance Database 2010 (LHID2010) sampled from the Taiwan National Health Insurance Research Database. Participants 4644 patients with non-traumatic ICH from 2010 to 2011 were identified. Patients aged <18 years and newly diagnosed with non-traumatic ICH complicated with pneumonia during the same admission period were excluded. A total of 2170 participants were eligible for the final analysis. Main outcome measure Patients using PPIs or not during the study period were tracked to identify the occurrence of any type of pneumonia. Results The adjusted HR of the risk of pneumonia for ICH patients who used PPIs was 1.61 (95% CI 1.32 to 1.97, p<0.001). The risk of pneumonia was positively associated with the administration of PPIs. We observed a greater risk of pneumonia in patients who used PPIs than in those who did not. Moreover, we observed that the risk of pneumonia in patients who used PPIs was 2.60 and 2.04 (95% CI 2.01 to 3.38, p<0.001; 95% CI 1.34 to 3.10, p<0.001) greater than that in patients who did not use PPIs when the defined daily dose was <30 and 30−60, respectively. Conclusions The results of this study indicate that the use of PPIs in patients with non-traumatic ICH is associated with an increased risk of pneumonia, and the severity of this risk depends on the defined daily dose. Physicians should exercise caution when prescribing PPIs for patients with non-traumatic ICH.

Transarterial Embolization for Traumatic Intractable Oronasal Hemorrhage

BACKGROUND Severe craniofacial injury may cause intractable oronasal bleeding, a rare but life-threatening surgical emergency that may occur in the Emergency Department (ED). Uncontrolled massive bleeding is the major cause of mortality. This kind of trauma is usually associated with the transfer of high kinetic energy such as a motor vehicle collision. OBJECTIVE We report an unusual case of intractable oronasal bleeding diagnosed by angiography. CASE REPORT A 43-year-old man was brought to the ED after being in a high-energy motor vehicle collision. He had suffered severe craniofacial trauma, including intracranial hemorrhage and intractable oronasal bleeding; he later developed a large pseudoaneurysm arising from the right internal maxillary artery. In the ED, the patient successfully underwent endovascular treatment (EVT) using angiography with transarterial embolization (TAE) therapy to control the bleeding. CONCLUSION EVT by TAE for intractable oronasal bleeding was an effective treatment in this life-threatening situation.

Major bleeding as spontaneous haemoperitoneum in a patient with factor V deficiency

Drs. Takedani, Solimeno, Saxena and Mathew were key contributors to the development of the HJV tool. Dr. Kalweit evaluated adherence data used to drive development of the HJV tool. Dr. Takedani was not involved in the collection or analysis of patient data. All authors were involved in drafting the publication and/or revising it critically for important intellectual content, and approving the final draft.

Duodenal perforation following blunt abdominal trauma presenting as normal in abdominal computed tomography

Most emergency department (ED) physicians implement the Advanced Trauma Life Support (ATLS) approach, including primary and secondary survey, for the assessment of blunt abdominal trauma (BAT) patients. This report emphasizes the need for repeat Focused Assessment with Sonography for Trauma (FAST) and abdominal computed tomography (CT) if a BAT patients condition persists or worsens. After initial negative FAST and abdominal CT findings, it is recommended that BAT patients with suspected intraabdominal injury should receive repeat examination in an optimal time. We report a patient who sustained duodenal perforation following BAT diagnosed by repeat ultrasound examination and abdominal CT scan. (Hong Kong j.emerg.med. 2014;21:396-399)

Association between Proton Pump Inhibitor Use and CNS Infection Risk: A Retrospective Cohort Study

This study investigated the incidence of central nervous system (CNS) infection following the use of proton pump inhibitors (PPIs). A retrospective cohort study was conducted in Taiwan by using data from the National Health Insurance Research Database. We identified and enrolled 16,241 patients with CNS infection who used PPIs (PPI users). The patients were individually propensity score matched (1:1) according to age, sex, hypertension, hyperlipidemia, Charlson comorbidity index (CCI), H2 blocker, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroid, and immunosuppressant use with 16,241 controls (PPI nonusers). A Cox proportional hazards model was used to estimate adjusted hazard ratio (aHR) for CNS infection in the PPI users and nonusers. After adjustment for other confounding factors, the incidence of CNS infection in the PPI users was 2.23-fold higher than that in the PPI nonusers (95% CI = 1.27–3.94). In addition, the PPI users exhibited a higher risk of CNS infection than the nonusers in the hypertension and CCI = 1 groups (aHR = 3.80, 95% CI = 1.40–10.32; aHR = 2.47, 95% CI = 1.07–5.70 in the PPI users and nonusers, respectively). In conclusions, according to these results, we concluded that the incidence of CNS infection was higher in the PPI users than in the nonusers.

Risk of pneumonia in patients with burn injury: a population-based cohort study

Background Burns are the main cause of accidental injury, and pneumonia is a common respiratory disease in humans. Aim The purpose of this study was to investigate the relationship between burn injury and pneumonia. Patients and methods A nationwide population-based cohort study was conducted using data from the National Health Insurance Research Database in Taiwan. We identified and enrolled 2,893 subjects with burn injury, who were individually matched to 2,893 subjects in the comparison group by using the propensity score. Furthermore, we used a self-controlled case-series design to estimate the temporal association between burn injury and pneumonia. Results Exposure to burn injury revealed a higher risk of pneumonia than that to non-burn injury within 1 year. The Cox proportional hazards model revealed that, compared with the non-burn injury, burn injury yielded a 2.39-fold (95% CI=1.44–3.96) increase in risk of pneumonia. The exposure period of burn injury within 30 days showed 2.76-fold increase in risk of pneumonia (95% CI=1.44–3.96) compared with that in the baseline period. Conclusion Burn injury was associated with a significant increased risk of pneumonia, especially occurring within 30 days.

Massive pulmonary embolism after overdose of oral benzodiazepine

Overdose of benzodiazepines rarely causes morbidity or mortality. A 58-year-old woman presented to the emergency department in coma after ingestion of 30 tablets of 0.5 mg alprazolam. She recovered after flumazenil was administered. However, massive pulmonary embolism developed during observation in the emergency department. Endotracheal intubation and recombinant tissue plasminogen activator infusion were initiated. This case report highlights that benzodiazepine overdose can contribute to pulmonary embolism which is a life-threatening condition.

Blunt traumatic cardiac rupture presenting as massive haemothorax

Cardiac rupture following blunt thoracic trauma in motor vehicle crash generally causes death at scene, and is rarely diagnosed preoperatively. However, early emergency thoracotomy in the emergency department (ED) or operating room might reduce the mortality but the benefit is still controversial. A haemodynamically unstable 28-year-old woman following motor vehicle crash was detected to have right haemothorax on chest X-ray. Thoracic computed tomography (CT) revealed additional lung contusions and multiple bone fractures. She developed cardiac arrest during open thoracotomy and had restored spontaneous circulation after open-chest cardiopulmonary resuscitation (CPR). This report highlights that CT scan in haemodynamically unstable patients could delay surgical control of the injury. Open-chest CPR can be life-saving for blunt chest injury developing cardiac arrest. (Hong Kong j.emerg.med. 2015;22:320-323)

Rupture of Ectopic Pelvic Dysplastic Kidney after Blunt Abdominal Trauma Presenting as Left Lower Quadrant Pain

BACKGROUND Ectopic pelvic dysplastic kidney is very rare. To our knowledge, there is no case report in the literature that discusses the diagnosis and management of ectopic pelvic dysplastic kidney in trauma. OBJECTIVES To report an unusual organ injury after abdominal blunt trauma. CASE REPORT A 23-year-old man presented to the Emergency Department with complaints of left lower quadrant pain after blunt abdominal trauma. Rupture of an ectopic pelvic dysplastic kidney was suspected from ultrasonography and then confirmed by a computed tomography scan. The patient was managed successfully with conservative therapy. CONCLUSIONS The focused assessment with sonography for trauma examination is beneficial to hemodynamically stable blunt abdominal trauma patients because unusual organ injuries can be detected early.