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Featured researches published by Yingjun Chen.


Journal of Refractive Surgery | 2015

Visual Outcomes and Optical Quality After Femtosecond Laser Small Incision Lenticule Extraction: An 18-Month Prospective Study

Huamao Miao; Mi Tian; Ye Xu; Yingjun Chen; Xingtao Zhou

PURPOSE To investigate the long-term visual outcomes and optical quality after femtosecond laser small incision lenticule extraction (SMILE) for moderate to high myopia correction. METHODS Fifty-four patients (37 women, 17 men) who underwent SMILE were enrolled in this prospective clinical study. Patient ages ranged from 18 to 40 years, with a mean spherical equivalent of -6.50 ± 1.64 diopters. Data including refractive parameters, retinal image quality, intraocular scattering, and aberrations were collected at 6 and 18 months after surgery. Patient satisfaction was also evaluated. RESULTS At 18 months after surgery, both the mean safety index and the efficacy index were 1.23 ± 0.23 (range: 0.80 to 1.50); there was no significant difference with indices measured at 6 months (P > .05). No patient lost two or more lines of corrected distance visual acuity. Total higher-order aberrations (HOAs) and coma significantly increased after SMILE (P < .05), whereas total spherical aberrations and trefoil changed only slightly. The mean modulation transfer function cutoff frequency was 36.66 ± 8.54 cycles per degree (cpd) before surgery and 37.81 ± 6.89 cpd at 18 months postoperatively; the mean objective scatter index was 0.62 ± 0.33 before surgery and 0.71 ± 0.38 at 18 months postoperatively. No significant difference was found between the three time points (P > .05). Mean patient satisfaction was 9.31 ± 0.64 (with a maximum score of 10). CONCLUSIONS SMILE showed good safety, efficacy, and stability in correcting moderate to high myopia, and patients were highly satisfied. HOAs increased after SMILE, mainly due to the increase of coma, whereas retinal image quality and intraocular scattering barely changed.


Scientific Reports | 2016

One-year Outcomes of Pachymetry and Epithelium Thicknesses after Accelerated (45 mW/cm(2)) Transepithelial Corneal Collagen Cross-linking for Keratoconus Patients.

Xiaoyu Zhang; Ling Sun; Yingjun Chen; Meiyan Li; Mi Tian; Xingtao Zhou

The thickness of corneal pachymetry and the epithelium after accelerated (45 mW/cm2) transepithelial corneal collagen cross-linking (CXL) for keratoconus were assessed in this prospective case series study. Twenty-eight patients were treated for keratoconus. The mean Kmax was 56.18 ± 7.90. The thinnest point, as assessed by optical coherence tomography (OCT), was 443.18 ± 39.75 μm. Accelerated transepithelial CXL was performed, and corrected distance visual acuity (CDVA), corneal topography, and OCT were recorded at 1 week postoperatively as well as at 1, 3, 6, and 12 months. The surgery was uneventful in all eyes. Postoperative epithelial edema was observed and faded in 3 days. The postoperative Kmax was 54.56 ± 8.81, 55.78 ± 8.11, 56.37 ± 8.71, 55.80 ± 7.92, and 55.47 ± 8.24 at 1 week, 1 month, 3 months, 6 months, and 12 months, respectively (all, P > 0.05). The thinnest postoperative corneal point, 439.04 ± 44.99 μm, was observed at 12 months (P = 0.109). The epithelial thickness decreased during the first postoperative week then showed a gradual recovery. Postoperative pachymetry thickness showed no significant changes for up to 12 months. Postoperative epithelial thickness decreased temporarily, then stabilized at month 12. Accelerated transepithelial CXL was shown to be effective and safe for the treatment of keratoconus.


Journal of Refractive Surgery | 2015

Lenticule Quality After Continuous Curvilinear Lenticulerrhexis in SMILE Evaluated With Scanning Electron Microscopy.

Yu Zhao; Meiyan Li; Ling Sun; Jing Zhao; Yingjun Chen; Xingtao Zhou

PURPOSE To evaluate the surface characteristics of lenticules extracted by continuous curvilinear lenticulerrhexis (CCL) in small incision lenticule extraction. METHODS Twelve eyes treated with small incision lenticule extraction were included in the study and divided into two groups: the CCL and traditional groups. The extracted lenticules were examined with scanning electron microscopy. Both the anterior and the posterior surfaces of the lenticules were accessed. A scoring system was used to evaluate surface characteristics of the lenticules with a full mark of 16. RESULTS All of the lenticules in the CCL group exhibited smoothness and regularity on both sides and received scores of 14 or 15. The average score of anterior surfaces was 14.83 ± 0.41 for the CCL group and 14.00 ± 2.45 for the traditional group. The average score for the posterior surfaces was 14.50 ± 0.55 for the CCL group and 14.83 ± 0.41 for the traditional group. CONCLUSIONS The surfaces of lenticules extracted by the CCL technique in small incision lenticule extraction are of good quality.


Scientific Reports | 2017

TGFBI Gene Mutation Analysis of Clinically Diagnosed Granular Corneal Dystrophy Patients Prior to PTK: A Pilot Study from Eastern China

Li Zeng; Jing Zhao; Yingjun Chen; Feng Zhao; Meiyan Li; Connie Chao-Shern; Tara Moore; John Marshall; Xingtao Zhou

This study investigated the TGFBI gene mutation types in outpatients clinically diagnosed with granular corneal dystrophy (GCD) prior to phototherapeutic keratectomy (PTK), also calculated the mutation rate of subjects with normal corneas, but positive family history. Clinical GCD outpatients and consanguineous family members were enrolled in this study. Among total 42 subjects: 24 patients from 23 unrelated families had typical signs of GCD on corneas; 5 patients from 5 unrelated families had atypical signs; 13 subjects from 11 unrelated families had no corneal signs but positive family history. Using Avellino gene test kit, the TGFBI mutation detection was performed on DNA samples from all subjects. 36 subjects were detected to carry heterozygous TGFBI gene mutations. Among 24 clinical GCD patients, the proportion of R124H, R555Q, R124L, R555W and R124C were 37.5%, 16.7%, 25.0%, 20.8% and 0%, respectively, and 2 patients had been diagnosed with GCD according to the opacities thriving after LASIK (R124H) and PRK (R555W). The mutation rate of 13 subjects having no signs but positive family history was 69.2%. R124H mutation is the most prominent mutation type among GCD outpatients in Eastern China. It is recommended to conduct gene detection for patients with positive family history prior to refractive surgeries.


Journal of Refractive Surgery | 2017

Three-Year Stability of Posterior Corneal Elevation After Small Incision Lenticule Extraction (SMILE) for Moderate and High Myopia.

Yu Zhao; Weijun Jian; Yingjun Chen; Michael C. Knorz; Xingtao Zhou

PURPOSE To investigate long-term changes in posterior corneal elevation after small incision lenticule extraction (SMILE). METHODS Thirty-six eyes of 20 patients (7 male, 13 female) who underwent SMILE were recruited for this prospective consecutive study. The mean preoperative manifest spherical equivalent was -6.24 ± 1.47 diopters (D) (range: -3.88 to -8.75 D). Posterior corneal surfaces were measured by a Scheimpflug camera (Pentacam; Oculus Optikgeräte GmbH, Wetzlar, Germany) preoperatively and at 1 month, 6 months, 12 months, 2 years, and 3 years after surgery. Posterior central elevation (PCE), posterior maximal elevation (PME), and posterior elevation at the thinnest corneal point (PTE) in the central 4-mm area above the best-fit sphere (BFS) were analyzed. The BFS was the same across all follow-up periods and determined by the preoperative data. A P value of less than .05 was considered statistically significant. RESULTS All surgeries were executed without complications and no case of keratectasia was observed during the follow-up. An uncorrected distance visual acuity of 20/20 or better was achieved in 100% of eyes at the last visit. The mean change of PCE, PME, and PTE at 3 years after the operation was -2.39 ± 2.85, 0.50 ± 3.33, and -2.33 ± 2.90 µm, respectively. There were significant differences in the measurements of PCE and PTE before surgery and 3 years after surgery (P ≤ .009); however, there was no significant difference in PME before surgery and 3 years after surgery (P = 1.000). No correlation was found between changes in posterior corneal elevation and residual bed thickness, ablation depth, and preoperative thinnest corneal thickness. CONCLUSIONS The posterior corneal surface, measured using the Pentacam, was stable after SMILE in the long-term follow-up. The cause of the slight backward change of PCE and PTE needs further study. [J Refract Surg. 2017;33(2):84-88.].


Journal of Refractive Surgery | 2017

A Three-Year Observation of Corneal Backscatter After Small Incision Lenticule Extraction (SMILE).

Tian Han; Jing Zhao; Yang Shen; Yingjun Chen; Mi Tian; Xingtao Zhou

PURPOSE To investigate changes in corneal backscatter after small incision lenticule extraction (SMILE). METHODS One eye was randomly selected from 34 patients who underwent SMILE procedures. Corneal backscatter was analyzed using Scheimpflug technology before surgery and at postoperative 1 day, 1 week, 1 month, 3, 6, and 12 months, and 3 years. Three different corneal depths (the anterior 120 µm, the center, and the posterior 60 µm) and three concentric radial zones (0 to 2, 2 to 6, and 6 to 10 mm) were analyzed. Another 40 eyes of 40 patients who underwent femtosecond laser-assisted LASIK (FS-LASIK) were examined before surgery and at postoperative 1 day and 3 years as the control group. RESULTS At postoperative day 1, a significant increase in corneal backscatter was detected in the SMILE group compared to preoperative values in the central 0 to 6 mm zone of the anterior layer and the 0 to 2 mm zone of the central layer (all P < .01). This increase was higher than the increase in the FS-LASIK group in the central 0 to 6 mm zone of the anterior and central layers (all P < .01). No significant differences in corneal backscatter were detected between preoperative values and the 1-week, and 1-, 3-, 6-, and 12-month follow-up visits in the SMILE group (all P > .05). Moreover, a significant decrease in corneal backscatter was detected in the three zones of all three layers in the two groups at 3 years postoperatively compared to preoperative values (all P < .001) and no significant difference was found between the two groups (all P < .05). CONCLUSIONS Corneal backscatter peaks and declines to the baseline in the early period after SMILE and corneal transparency achieves an improvement within 3 years postoperatively. [J Refract Surg. 2017;33(6):377-382.].


Journal of Refractive Surgery | 2018

Two-Year Outcome of a Patient Treated With Phototherapeutic Keratectomy and Autologous SMILE Lenticule Transplantation for Flap-Related Complications Following LASIK

Jing Zhao; Feng Zhao; Jinrong Huang; Haipeng Xu; Yingjun Chen; Xingtao Zhou

PURPOSE To describe a patient with flap complications after LASIK who was subsequently treated using phototherapeutic keratectomy (PTK) and an autologous lenticule transplant obtained via small incision lenticule extraction (SMILE). METHODS A 23-year-old man experienced free flap and partial flap loss in the left eye following LASIK, resulting in corneal stroma opacity 1 month later. The manifest refraction was -3.25 diopters sphere (DS)/-0.50 diopters cylinder (DC) × 100° in the right eye and +2.50 DS/-1.25 DC × 155° in the left eye. His left eye was treated with PTK and transplantation of an autologous lenticule obtained from his right eye using the SMILE procedure. RESULTS At the 2-year follow-up visit, the uncorrected distance visual acuity of the left eye had improved from 20/100 to 20/22 and the corrected distance visual acuity had improved from 20/25 to 20/18. Central corneal thickness had increased from 464 to 499 µm. The mean keratometry value had decreased from 45.00 diopters (D) at the 1-month follow-up visit to 39.40 D at the 2-year follow-up visit. Optical coherence tomography examination revealed that the lenticule remained transparent and exhibited a visible demarcation line. CONCLUSIONS The transplantation of an autologous lenticule obtained via SMILE combined with PTK improved uncorrected and corrected acuity in this patient with flap loss after LASIK. [J Refract Surg. 2018;34(4):281-285.].


BMC Ophthalmology | 2016

Four-year observation of predictability and stability of small incision lenticule extraction

Tian Han; Ke Zheng; Yingjun Chen; Yang Gao; Li He; Xingtao Zhou


BMC Ophthalmology | 2018

Refractive outcomes and optical quality after implantation of posterior chamber phakic implantable collamer lens with a central hole (ICL V4c)

Huamao Miao; Xun Chen; Mi Tian; Yingjun Chen; Xiao-Ying Wang; Xingtao Zhou


BMC Ophthalmology | 2018

Ocular dimensions of the Chinese adolescents with keratoconus

Weijun Jian; Yang Shen; Yingjun Chen; Mi Tian; Xingtao Zhou

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