Yingmei Qin

Weak electric fields detectability in a noisy neural network

We investigate the detectability of weak electric field in a noisy neural network based on Izhikevich neuron model systematically. The neural network is composed of excitatory and inhibitory neurons with similar ratio as that in the mammalian neocortex, and the axonal conduction delays between neurons are also considered. It is found that the noise intensity can modulate the detectability of weak electric field. Stochastic resonance (SR) phenomenon induced by white noise is observed when the weak electric field is added to the network. It is interesting that SR almost disappeared when the connections between neurons are cancelled, suggesting the amplification effects of the neural coupling on the synchronization of neuronal spiking. Furthermore, the network parameters, such as the connection probability, the synaptic coupling strength, the scale of neuron population and the neuron heterogeneity, can also affect the detectability of the weak electric field. Finally, the model sensitivity is studied in detail, and results show that the neural network model has an optimal region for the detectability of weak electric field signal.

Intrinsic excitability state of local neuronal population modulates signal propagation in feed-forward neural networks.

Reliable signal propagation across distributed brain areas is an essential requirement for cognitive function, and it has been investigated extensively in computational studies where feed-forward network (FFN) is taken as a generic model. But it is still unclear how distinct local network states, which are intrinsically generated by synaptic interactions within each layer, would affect the ability of FFN to transmit information. Here we investigate the impact of such network states on propagating transient synchrony (synfire) and firing rate by a combination of numerical simulations and analytical approach. Specifically, local network dynamics is attributed to the competition between excitatory and inhibitory neurons within each layer. Our results show that concomitant with different local network states, the performance of signal propagation differs dramatically. For both synfire propagation and firing rate propagation, there exists an optimal local excitability state, respectively, that optimizes the performance of signal propagation. Furthermore, we find that long-range connections strongly change the dependence of spiking activity propagation on local network state and propose that these two factors work jointly to determine information transmission across distributed networks. Finally, a simple mean field approach that bridges response properties of long-range connectivity and local subnetworks is utilized to reveal the underlying mechanism.

Epileptic seizure detection of electroencephalogram based on weighted-permutation entropy

Weighted-permutation entropy (WPE) is modified from permutation entropy (PE), which recently has been proposed as a measurement for nonlinear time series. To explore the efficiency of this method and the features of seizure electroencephalogram (EEG) segments, we investigate the application of WPE in the complexity analysis for epileptic seizure detection based on EEG. It is found that the calculated values of WPE are decreased during seizure segments in the contrast with seizure-free. Moreover, WPE provides a highly distinguishable feature for classifier to obtain more accurate results of automatic classification compared with PE by support vector machine (SVM).

Propagation of Collective Temporal Regularity in Noisy Hierarchical Networks

Neuronal communication between different brain areas is achieved in terms of spikes. Consequently, spike-time regularity is closely related to many cognitive tasks and timing precision of neural information processing. A recent experiment on primate parietal cortex reports that spike-time regularity increases consistently from primary sensory to higher cortical regions. This observation conflicts with the influential view that spikes in the neocortex are fundamentally irregular. To uncover the underlying network mechanism, we construct a multilayered feedforward neural information transmission pathway and investigate how spike-time regularity evolves across subsequent layers. Numerical results reveal that despite the obviously irregular spiking patterns in previous several layers, neurons in downstream layers can generate rather regular spikes, which depends on the network topology. In particular, we find that collective temporal regularity in deeper layers exhibits resonance-like behavior with respect to both synaptic connection probability and synaptic weight, i.e., the optimal topology parameter maximizes the spike-timing regularity. Furthermore, it is demonstrated that synaptic properties, including inhibition, synaptic transient dynamics, and plasticity, have significant impacts on spike-timing regularity propagation. The emergence of the increasingly regular spiking (RS) patterns in higher parietal regions can, thus, be viewed as a natural consequence of spiking activity propagation between different brain areas. Finally, we validate an important function served by increased RS: promoting reliable propagation of spike-rate signals across downstream layers.Neuronal communication between different brain areas is achieved in terms of spikes. Consequently, spike-time regularity is closely related to many cognitive tasks and timing precision of neural information processing. A recent experiment on primate parietal cortex reports that spike-time regularity increases consistently from primary sensory to higher cortical regions. This observation conflicts with the influential view that spikes in the neocortex are fundamentally irregular. To uncover the underlying network mechanism, we construct a multilayered feedforward neural information transmission pathway and investigate how spike-time regularity evolves across subsequent layers. Numerical results reveal that despite the obviously irregular spiking patterns in previous several layers, neurons in downstream layers can generate rather regular spikes, which depends on the network topology. In particular, we find that collective temporal regularity in deeper layers exhibits resonance-like behavior with respect to both synaptic connection probability and synaptic weight, i.e., the optimal topology parameter maximizes the spike-timing regularity. Furthermore, it is demonstrated that synaptic properties, including inhibition, synaptic transient dynamics, and plasticity, have significant impacts on spike-timing regularity propagation. The emergence of the increasingly regular spiking (RS) patterns in higher parietal regions can, thus, be viewed as a natural consequence of spiking activity propagation between different brain areas. Finally, we validate an important function served by increased RS: promoting reliable propagation of spike-rate signals across downstream layers.

Effects of topologies on signal propagation in feedforward networks

We systematically investigate the effects of topologies on signal propagation in feedforward networks (FFNs) based on the FitzHugh-Nagumo neuron model. FFNs with different topological structures are constructed with same number of both in-degrees and out-degrees in each layer and given the same input signal. The propagation of firing patterns and firing rates are found to be affected by the distribution of neuron connections in the FFNs. Synchronous firing patterns emerge in the later layers of FFNs with identical, uniform, and exponential degree distributions, but the number of synchronous spike trains in the output layers of the three topologies obviously differs from one another. The firing rates in the output layers of the three FFNs can be ordered from high to low according to their topological structures as exponential, uniform, and identical distributions, respectively. Interestingly, the sequence of spiking regularity in the output layers of the three FFNs is consistent with the firing rates, but their firing synchronization is in the opposite order. In summary, the node degree is an important factor that can dramatically influence the neuronal network activity.

Weak signal detection and propagation in diluted feed-forward neural network with recurrent excitation and inhibition

Reliable signal propagation across distributed brain areas provides the basis for neural circuit function. Modeling studies on cortical circuits have shown that multilayered feed-forward networks (FFNs), if strongly and/or densely connected, can enable robust signal propagation. However, cortical networks are typically neither densely connected nor have strong synapses. This paper investigates under which conditions spiking activity can be propagated reliably across diluted FFNs. Extending previous works, we model each layer as a recurrent sub-network constituting both excitatory (E) and inhibitory (I) neurons and consider the effect of interactions between local excitation and inhibition on signal propagation. It is shown that elevation of cellular excitation–inhibition (EI) balance in the local sub-networks (layers) softens the requirement for dense/strong anatomical connections and thereby promotes weak signal propagation in weakly connected networks. By means of iterated maps, we show how elevated loc...

Toward heterogeneity in feedforward network with synaptic delays based on FitzHugh–Nagumo model

We focus on the role of heterogeneity on the propagation of firing patterns in feedforward network (FFN). Effects of heterogeneities both in parameters of neuronal excitability and synaptic delays are investigated systematically. Neuronal heterogeneity is found to modulate firing rates and spiking regularity by changing the excitability of the network. Synaptic delays are strongly related with desynchronized and synchronized firing patterns of the FFN, which indicate that synaptic delays may play a significant role in bridging rate coding and temporal coding. Furthermore, quasi-coherence resonance (quasi-CR) phenomenon is observed in the parameter domain of connection probability and delay-heterogeneity. All these phenomena above enable a detailed characterization of neuronal heterogeneity in FFN, which may play an indispensable role in reproducing the important properties of in vivo experiments.

Vibrational resonance in a randomly connected neural network

A randomly connected network is constructed with similar characteristics (e.g., the ratio of excitatory and inhibitory neurons, the connection probability between neurons, and the axonal conduction delays) as that in the mammalian neocortex and the effects of high-frequency electrical field on the response of the network to a subthreshold low-frequency electrical field are studied in detail. It is found that both the amplitude and frequency of the high-frequency electrical field can modulate the response of the network to the low-frequency electric field. Moreover, vibrational resonance (VR) phenomenon induced by the two types of electrical fields can also be influenced by the network parameters, such as the neuron population, the connection probability between neurons and the synaptic strength. It is interesting that VR is found to be related with the ratio of excitatory neurons that are under high-frequency electrical stimuli. In summary, it is suggested that the interaction of excitatory and inhibitory currents is also an important factor that can influence the performance of VR in neural networks.

FPGA-based hardware simulation of nonlinear autoregressive Volterra model to reconstruct the single neuron spike pattern

This study explores the implementation of the nonlinear autoregressive Volterra (NARV) model using a field programmable gate arrays (FPGAs)-based hardware simulation platform and accomplishes the identification process of the Hodgkin–Huxley (HH) model. First, a physiological detailed single-compartment HH model is applied to generate experiment data sets and the electrical behavior of neurons are described by the membrane potential. Then, based on the injected input current and the output membrane potential, a second-order NARV model is constructed and implemented on FPGA-based simulation platforms. The NARV modeling method is data-driven, requiring no accurate physiological information and the FPGA-based hardware simulation can provide a real time and high-performance platform to deal with the drawbacks of software simulation. Therefore, the proposed method in this paper is capable of handling the nonlinearities and uncertainties in nonlinear neural systems and may help promote the development of clinical treatment devices.

Epileptic seizure detection from EEG signals with phase–amplitude cross-frequency coupling and support vector machine

As a pattern of cross-frequency coupling (CFC), phase–amplitude coupling (PAC) depicts the interaction between the phase and amplitude of distinct frequency bands from the same signal, and has been proved to be closely related to the brain’s cognitive and memory activities. This work utilized PAC and support vector machine (SVM) classifier to identify the epileptic seizures from electroencephalogram (EEG) data. The entropy-based modulation index (MI) matrixes are used to express the strength of PAC, from which we extracted features as the input for classifier. Based on the Bonn database, which contains five datasets of EEG segments obtained from healthy volunteers and epileptic subjects, a 100% classification accuracy is achieved for identifying seizure ictal from healthy data, and an accuracy of 97.67% is reached in the classification of ictal EEG signals from inter-ictal EEGs. Based on the CHB–MIT database which is a group of continuously recorded epileptic EEGs by scalp electrodes, a 97.50% classificat...