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Featured researches published by Yogo Oka.


The Journal of Pediatrics | 1976

Leukocyte glutathione peroxidase deficiency in a male patient with chronic granulomatous disease

Ichiro Matsuda; Yogo Oka; Naoyuki Taniguchi; Masayuki Furuyama; Susumu Kodama; Shinichiro Arashima; Takashi Mitsuyama

A male child with chronic granulomatous disease is described in whom glutathione peroxidase deficiency of leukocytes was identified. Stability and activity of G-6-PD and activity of NADPH oxidase were normal. The leukocytes of the parents showed intermediate activities of glutathione peroxidase, suggesting the possibility of autosomal recessive inheritance.


The Journal of Pediatrics | 1975

Renal tubular acidosis and skeletal demineralization in patients on long-term anticonvulsant therapy

Ichiro Matsuda; Yasuo Takekoshi; Naoyoshi Shida; Kenji Fujieda; Bunsaku Nagai; Shinichiro Arashima; Michiya Anakura; Yogo Oka

Three children ranging from seven to 12 years of age from unrelated families were given long-term anticonvulsant therapy including acetazolamide (Diamox). These children had rickets and renal tubular acidosis. Investigations have suggested (1) secondary hyperparathyroidism due to hypocalcemia of rickets and (2) prolonged acetazolamide therapy were responsible for acidosis as a result of reduction of bicarbonate reabsorption in the kidney. A clear-cut recovery from acidosis and rickets was seen in two patients following medication with high doses of vitamin D, an oral supplement of phosphorus, and discontinuance of acetazolamide therapy.


Human Genetics | 1975

Prenatal diagnosis of I-cell disease

Ichiro Matsuda; Shinichiro Arashima; Takashi Mitsuyama; Yogo Oka; Tatsuo Ikeuchi; Yasuhiko Kaneko; Mutsuo Ishikawa

SummaryA pregnancy from a family in risk of I-cell disease was monitored. The fetus was diagnosed as having I-cell disease based on the findings that (1) lysosomal enzyme activities except for acid phosphatase and α glucosidase were clearly elevated in amniotic fluid and were reduced in cultivated amniotic fluid cells, and (2) cytoplasmic inclusions were seen in cultivated amniotic cells by phase contrast microscopy. The accuracy of prediction was confirmed by cultured skin fibroblast of the aborted fetus.


Pediatric Research | 1976

Ultrastructural studies in fetal I-cell disease.

Kazuhiro Abe; Ichiro Matsuda; Shinichiro Arashima; Takashi Mitsuyama; Yogo Oka; Mutsuo Ishikawa

Extract: The skin, brain, lung, liver, and kidney from a 20-week-old fetus who was diagnosed as having fetal I-cell disease by amniocentesis at 14 weeks of gestation were examined by light and electron microscopy. In addition, cultured fibroblasts from the skin were also observed microscopically. Cytoplasmic inclusions with dense polymorphic contents appeared commonly in the capillary endothelial cells in the skin, lung, glomerulus of the kidney, and the epithelial cells of the proximal tubules of the kidney, and sometimes in the hepatocytes of the liver and the nerve and glial cells of the brain. Erythropoietic cells in the liver and circulating erythrocytes contained dense inclusions varying in developmental stages. Fibroblasts of the skin had several clear vacuoles, and cultured fibroblasts were filled with dense inclusions. The dense cytoplasmic inclusions in fetal I-cell disease were light and electron microscopically similar to the residual bodies which are commonly observed in the phagocytic cells.Speculation: In fetal I-cell disease, the cytoplasmic inclusions may first appear as dense bodies in the capillary endothelial cells of fetus as early as 4 weeks of gestation. Material stored in the inclusions may reflect deranged metabolism of the cells. Thus, the morphologic changes of I-cell disease may be due to the deficiencies of intralysosomal enzymes.


Clinica Chimica Acta | 1973

α-l-Fucosidase and α-d-mannosidase activity in the white blood cells in the disease and carrier state of fucosidosis

Ichiro Matsuda; Shinichiro Arashima; Michiya Anakura; Yogo Oka

Abstract α- l -Fucosidase and α- d -mannosidase activity in white blood cells from a patient with fucosidosis and her family members were studied. α- l -Fucosidase activity of the patient was completely lacking, whereas the α- l -mannosidase activity was increased and relative thermostability of this enzyme was also observed. Apparent K m value of α- d -mannosidase was similar in the patient and the control. When the ratio of α- l -fucosidase to α- d -mannosidase activity was calculated, the value of the parents was intermediate between that of the patient and the control.


Pediatric Research | 1979

Metabolic acidosis in patients receiving anticonvulsants

Bunsaku Nagai; Ichiro Matsuda; Takahito Kondo; Naoyuki Taniguchi; Shinichiro Arashima; Takashi Mitsuyama; Yogo Oka; Masakatsu Honma

Blood pH, bicarbonate, PCO2, serum calcium, alkaline phosphatase and red cell carbonic anhydrase were measured in 37 selected patients receiving anticonvulsants. Patients with metabolic acidosis showed a high incidence of hypocalcemia with increased alkaline phosphatase and a significant reduction of carbonic anhydrase-B activity. High iPTH levels were found in 13 patients, but this was not correlated with acid-base balance status. Anticonvulsant drugs seemed to inactive carbonic anhydrase-B activity. Metabolic acidosis might be one of the factors causing a disturbance of calcium metabolism in these patients.


European Journal of Pediatrics | 1977

The effects of oral alanine administration on blood glucose, pyruvate, lactate, serum glucagon and insulin in human newborns.

Yogo Oka; Ichiro Matsuda; Haruo Nambu; Bunsaku Nagai; Takashi Mitsuyama; Shinichiro Arashima

Alanine (500 mg/kg body weight) was given orally to 27 healthy full term newborn infants, and the changes in blood glucose, pyruvate, lactate, alanine, glucagon and insulin were determined.Significant increments in blood glucose were found in 15 infants with blood glucose levels below 60 mg/100 ml, 4 of whom showed significant elevation of serum glucagon levels on day 1. This observation suggests that hepatic gluconeogenesis is possible immediately after birth.


Tohoku Journal of Experimental Medicine | 1976

Citrate Treatment in a Patient with Pyruvate Decarboxylase Deficiency

Yogo Oka; Ichiro Matsuda; Shinichiro Arashima; Michiya Anakura; Takashi Mitsuyama; Ichimei Nagamatsu


The Journal of Pediatrics | 1976

A variant form of citrullinemia

Ichiro Matsuda; Michiya Anakura; Sinichiro Arshima; Yoshiro Saito; Yogo Oka


Tohoku Journal of Experimental Medicine | 1985

Serum zinc and copper concentrations in low birth weight infants during first three months of life: Correlation to birth weight and different feedings.

Akimasa Higashi; Ichiro Matsuda; Tadashi Masumoto; Hiroaki Saikusa; Masamitsu Yabuso; Yogo Oka

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