Yohei Hamade

Wells' Syndrome Associated with Chronic Myeloid Leukaemia

© 2013 The Authors. doi: 10.2340/00015555-1483 Journal Compilation

Loss-of-function mutations in the gene encoding filaggrin underlie a Japanese family with food-dependent exercise-induced anaphylaxis.

Food‐dependent exercise‐induced anaphylaxis (FDEIA) is a serious food allergy in which anaphylaxis develops when exercise is performed within several hours after food intake. The precise mechanism underlying allergic sensitization in FDEIA has been an important issue but remains poorly understood.

Anti-laminin-gamma 1 Pemphigoid with Generalized Pustular Psoriasis and Psoriasis Vulgaris.

Title Anti-laminin-gamma 1 Pemphigoid with Generalized Pustular Psoriasis and Psoriasis Vulgaris Author(s) Fujimura, Yu; Natsuga, Ken; Hamade, Yohei; Nomura, Yukiko; Kaku, Yo; Muramatsu, Ryuichi; Shimizu, Hiroshi Citation Acta dermato-venereologica, 96(1), 120-121 https://doi.org/10.2340/00015555-2168 Issue Date 2016-01 Doc URL http://hdl.handle.net/2115/60856 Type article File Information 4463.pdf

The different intensity of autoantibody deposits in bullous pemphigoid associated with psoriasis vulgaris

Bullous pemphigoid (BP), an autoimmune blistering disease, demonstrates subepidermal tense blisters with erythema and the presence of circulating autoantibodies against type XVII collagen (COL17) and/or BP230. The incidence of BP has been estimated at 4.28 per 100,000 person years in the United Kingdom [1]. More than 50 cases of BP associated with psoriasis vulgaris have been reported [2]. Grattan reported the prevalence of pemphigoid associated with psoriasis to be significantly higher than expected [...]

Repeated skin sampling and prolonged incubation period identified cutaneous Mycobacterium chelonae infection on the face in an immunocompetent man

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CADM1 is a diagnostic marker in early-stage mycosis fungoides: Multicenter study of 58 cases

Background: Mycosis fungoides (MF) is the most common cutaneous T‐cell lymphoma. Early‐stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 gene (CADM1), which was initially identified as a tumor suppressor gene in human non–small cell lung cancer, has been reported as a diagnostic marker for adult T‐cell leukemia/lymphoma. Objective: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF. Methods: We conducted a retrospective study by using immunohistochemical staining and confirmed the expression of CADM1 in MF. In addition, we compared CADM1 messenger RNA expression in microdissected MF samples and ISD samples. Results: In the overall study period, 55 of 58 MF samples (94.8 %) stained positive for CADM1. None of the 50 ISD samples showed positive reactivity (P < .0001). We found CADM1 messenger RNA expression in the intradermal lymphocytes of patients with MF but not in those of patients with an ISD. Limitations: We did not conduct a validation study for MF cases in other institutions. Conclusions: CADM1‐positive cells can be identified in early stages with fewer infiltrating cells and may be useful as a diagnostic marker for early‐stage MF.

Localized pemphigus vulgaris clinically masquerading as lichen planus and actinic keratosis

1 Truong SV, Chang LC, Berger TG. Bisphosphonate-related osteonecrosis of the jaw presenting as a cutaneous dental sinus tract: a case report and review of the literature. J Am Acad Dermatol 2010; 62: 672–676. 2 Boquete-Castro A, G omez-Moreno G, Calvo-Guirado JL, Aguilar-Salvatierra A, Delgado-Ruiz RA. Denosumab and osteonecrosis of the jaw. A systematic analysis of events reported in clinical trials. Clin Oral Implants Res 2015; doi: 10.1111/clr.12556. 3 Allen MR. Bisphosphonates and osteonecrosis of the jaw: moving from the bedside to the bench. Cells Tissues Organs 2009; 189: 289– 294. 4 Santini D, Vincenzi B, Dicuonzo G et al. Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients. Clin Cancer Res 2003; 9: 2893–2897. 5 Khan AA, Morrison A, Hanley DA et al. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res 2015; 30: 3–23.

Structural phase transition in the perovskite-type tantalum oxynitrides, Ca{sub 1-x}Eu{sub x}Ta(O,N){sub 3}

Pure Ca1-xEuxTa(O,N)3 were successfully synthesized in the whole range of Ca/Eu compositions by means of ammonia nitridation via a citrate precursor route. As-nitrided products with x < 0.4 were apparently orthorhombic, while those with x ≥ 0.4 crystallized in a cubic structure. The anionic composition was found to be essentially O2N and independent of Eu content (x). The as-nitrided EuTaO2N possessed a cubic perovskite-type structure, while high-temperature post-annealing led to a tetragonal EuTaO2N phase with better crystallinity. The re-nitridation transformed the post-annealed product into the original cubic lattice, which might be an average of the tetragonal micro domains.