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Publication
Featured researches published by Yoichi Naka.
Bioorganic & Medicinal Chemistry Letters | 1995
Yukio Hitotsuyanagi; Keiji Yamagami; Akihiro Fujii; Yoichi Naka; Yukiyasu Ito; Tetsuya Tahara
Abstract 2,4-Diaza-4-desoxypodophyllotoxin analogs have been synthesized from substituted anilines. Some of them showed promising antitumor activities against vincristine-resistant P388 murine leukemia and B16 melanoma in vivo.
Journal of The Chemical Society, Chemical Communications | 1995
Yukio Hitotsuyanagi; Yoichi Naka; Keiji Yamagami; Akihiro Fujii; Tetsuya Tahara
2,4-Diaza-4-deoxypodophyllotoxin 4 and its cis analogue 14 are synthesised stereoselectively from 3,4-methylenedioxyaniline 5, and show significant activity against vincristine-resistant P-388 leukaemia in vivo.
Bioorganic & Medicinal Chemistry Letters | 1995
Yoichi Naka; Ichimaro Yamada; Hiroshi Ochi; Mamoru Matsuura; Yuko Nagamatsu; Takanori Oe
Abstract Several alkyl-analogues of pranoprofen were synthesized and their cyclooxygenase inhibitory activities were evaluated in a screening test. The chosen compounds were analyzed on the relationships between structure, lipophilicity (log P) and cell binding affinity. 2-Methyl analogue ( 4b ) was confirmed to be an optimal compound in this series.
Archive | 1988
Yoichi Naka; Yukio Hitotsuyanagi; Keiichiro Haga; Masahiro Hosoya
Archive | 1988
Yoichi Naka; Yukio Hitotsuyanagi; Keiichiro Haga; Masahiro Hosoya
Archive | 1993
Yoichi Naka; Keiichiro Haga; Masahiro Hosoya
Archive | 1991
Yoichi Naka; Keiichiro Haga; Masahiro Hosoya
Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1989
Mineo Tsuruda; Hiroshi Mikashima; Takanori Oe; Kazuyuki Kawasaki; Shinro Setoguchi; Yoichi Naka; Tetsuya Tahara
Archive | 1991
Yoichi Naka; Keiichiro Haga; Masahiro Hosoya
Archive | 1991
Yoichi Naka; Keiichiro Haga; Masahiro Hosoya
Collaboration
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