Yoichi Naka

Syntheses and biological properties of novel aza-podophyllotoxin analogs prossessing pronounced antitumor activity

Abstract 2,4-Diaza-4-desoxypodophyllotoxin analogs have been synthesized from substituted anilines. Some of them showed promising antitumor activities against vincristine-resistant P388 murine leukemia and B16 melanoma in vivo.

Synthesis of 2,4-diaza-4-deoxypodophyllotoxin, a new analogue of podophyllotoxin possessing antitumour activity

2,4-Diaza-4-deoxypodophyllotoxin 4 and its cis analogue 14 are synthesised stereoselectively from 3,4-methylenedioxyaniline 5, and show significant activity against vincristine-resistant P-388 leukaemia in vivo.

STRUCTURAL OPTIMIZATION OF ALKYL-SUBSTITUTED 2-(7-5H-1 BENZOPYRANO 2,3-B PYRIDYL) PROPIONIC ACID AS ANTI-INFLAMMATORY AGENTS

Abstract Several alkyl-analogues of pranoprofen were synthesized and their cyclooxygenase inhibitory activities were evaluated in a screening test. The chosen compounds were analyzed on the relationships between structure, lipophilicity (log P) and cell binding affinity. 2-Methyl analogue ( 4b ) was confirmed to be an optimal compound in this series.