Yong Hae Kim

A new antitumor agent: methyl sulfonium perchlorate of echinomycin.

Newly modified-echinomycin such as S-methylated sulfonium perchlorate of echinomycin (1), monosulfoxide (2), disulfoxid (3) and sulfone (4) have been prepared and evaluated for in vitro biological activities of cytotoxicity against P388, B16 and SNU-16 as well as in vivo antitumor activity against murine leukemia P388 and melanoma B16.

Synthesis of 4‐Alkyl‐1(2H)‐phthalazinones and 4‐Alkyl‐2,3‐benzoxazin‐1‐ones via Ring Cleavage of 3‐Substituted N‐Alkylated‐3‐hydroxyisoindolin‐1‐ones

Abstract N‐Alkyl (Me, Et, i‐Pr, t‐Bu)‐substituted phthalimdes 5a–d were easily transformed to 1(2H)‐phthalazinones 8d–i and 2,3‐benzoxazin‐1‐ones 9d, f, and j via a one‐pot addition–decyclization–cyclocondensation process.

Synthesis of Multi-substituted Pyrazoles Utilizing the N-Alkylated 3-Hydroxy-3-propargyl- or allenylisoindolines

N-Alkyl-substituted phthalimides (1) were easily converted to di-, tri-, and tetra-substituted pyrazoles (10) via a one-pot addition-decyclization-cyclocondensation process. Then, the structure and the position of N1-substitution of the 1,3-pyrazole ring were determined by X-Ray crystallographic analysis and 1 H-nOe experiments.

P222 Korean herbal medicine for the treatment of chronic prostatitis: A research of world wide web

P221 Tuberculosis examination using Quantiferon-TB Gold in Tube among health care workers in a Japanese hospital E. Adachi1 *, M. Kogayu2, T. Fujii1 , H. Mae3, S. Shimizu1, H. Shibata4, M. Suzuki4, A. Iwamoto1,5, K. Imai6, T. Koibuchi1. 1 Department of Infectious Diseases and Applied Immunology, 2Department of Nursing, IMSUT Hospital of The Institute of Medical Science, 3 Department of Pharmacy, 4 Department of Laboratory Medicine, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, 5 Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 6Director, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Tokyo, Japan E-mail address : e-adachi@ims.u-tokyo.ac.jp