Yong Ho Chung

Benzotriazol-1-yl Alkyl Carbonate, A New Convenient and Inexpensive Coupling Agent to Prepare an Active Ester for the Synthesis of Amide

Abstract Benzotriazol-1-yl alkyl carbonate 1 has been found to be a new convenient and inexpensive coupling agent to prepare an active ester 2 for the synthesis of an amide 3 in good yield and with high purity.

Immunomodulating activity of DW-116, a new quinolone antibiotic

DW-116, {1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride}, is a new quinolone antibiotic with a broad antibacterial spectrum against G(+) and G(−) bacteria. DW-116 was evaluated for the immunomodulating activities, which is one of the efforts to investigate the mechanism of action related to the goodin vivo antibacterial efficacy. The results ofin vitro studies revealed there was no statistically significant increase in B and T lymphocyte proliferation. But the results ofin vivo studies showed that the number of plaque forming cells (PFC), the amount of polyclonal antibodies and delayed-type hypersensitivity (DTH) were significantly increased after the repeat administration with 12 and 60 mg/kg of DW-116. Taken together, these results proposed that immunostimulating effect of DW-116 could be one of the action mechanisms for demonstratingin vivo antibacterial activities under these experimental conditions.