Yongtao Xie

Design, synthesis and herbicidal activity study of aryl 2,6-disubstituted sulfonylureas as potent acetohydroxyacid synthase inhibitors

A series of sulfonylurea derivatives containing a 2,6-disubstituted aryl moiety were designed, synthesized and evaluated for their herbicidal activities. Most of these compounds showed excellent inhibitory rates against both monocotyledonous and dicotyledonous weeds, especially 10a, 10h and 10i. They exhibited equivalent or superior herbicidal efficiency than commercial chlorsulfuron at the dosage of 15g/ha and the preliminary SAR was summarized. In order to illuminate the molecular mechanism of several potent compounds, their apparent inhibition constant (Kiapp) of Arabidopsis thaliana acetohydroxyacid synthase (AHAS) were determined and the results confirmed that these compounds were all potent AHAS inhibitors. 10i have a Kiapp of 11.5nM, which is about 4 times as potent as chlorsulfuron (52.4nM).

Synthesis, insecticidal activities and structure–activity relationship study of dual chiral sulfilimines

To investigate the “methyl” impact on bioactivity of sulfiliminyl dicarboxamides, a total of 16 novel N-cyano and N-trifluoroacetyl sulfiliminyl dicarboxamides containing m-heptafluoroisopropylated aromatic amino moiety were studied. Two series of sulfiliminyl substituents were designed, synthesized and evaluated against oriental armyworm (Pseudaletia separata Walker) for their insecticidal activities. Their chemical structures were established by corresponding

Sulfimine-Promoted Fast O Transfer: One-step Synthesis of Sulfoximine from Sulfide

^{1}\hbox {H}

Design, Synthesis, Biological Evaluation and SARs of Novel Anthranilic Diamides Derivatives Containing Amide, Carbamate, Urea, and Thiourea Moieties

1H NMR, HRMS and optical polarimetry. Bioassay results revealed that some of the title compounds showed potent insecticidal activities against oriental armyworm. Notably, compounds IIa, IIIa, IVa exhibited 100% activity at

Design, Synthesis, Biological Evaluation and SARs of Novel N-Substituted Sulfoximines as Potential Ryanodine Receptor Modulators: Design, Synthesis, Biological Evaluation and SARs of Novel N-Substituted Sulfoximines as Potential Ryanodine Receptor Modulators

1\, \hbox {mg}\,\hbox {L}^{-1}

Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives

1mgL-1, in particular, IIa showed a comparable control efficacy to that of the commercial product flubendiamide. The SAR of these N-cyano sulfiliminyl isomers can be summarized as follows (Sc, Ss)