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Diabetes & Metabolism Journal | 2012

Intracerebroventricular Injection of Metformin Induces Anorexia in Rats

Chang Koo Lee; Yoon Jung Choi; So Young Park; Jong Yeon Kim; Kyu Chang Won; Yong Woon Kim

Background Metformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known. Methods To evaluate whether metformin induces anorexia via the hypothalamus, various concentrations of metformin were injected into the lateral ventricle of rats through a chronically implanted catheter and food intake was measured for 24 hours. The hypothalamic neuropeptides associated with regulation of food intake were also analyzed following 1 hour of intracerebroventricular (ICV) injections of metformin. Results An ICV injection of metformin decreased food intake in a dose-dependent manner in unrestrained conscious rats. Hypothalamic phosphorylated AMP-activated protein kinase (pAMPK) increased by 3 µg with metformin treatment, but there was no further increase in pAMPK with increases in metformin dosage. The hypothalamic phosphorylated signal transducer and activator of transcription 3 (pSTAT3) increased by 3 µg with metformin treatment, but, there was no further increase in pSTAT3 level following increases of metformin dosage. Hypothalamic proopiomelanocortin was elevated with metformin treatment, while neuropeptide Y was not significantly changed. Conclusion Our results suggest that metformin induces anorexia via direct action in the hypothalamus and the increase in pSTAT3, at least in part, is involved in the process. However, hypothalamic pAMPK appears not to contribute to metformin-induced appetite reduction in normal rats. Further studies exploring new pathways connecting metformin and feeding regulation are needed.


Korean Circulation Journal | 2017

The Use Pattern and Clinical Impact of New Antiplatelet Agents Including Prasugrel and Ticagrelor on 30-day Outcomes after Acute Myocardial Infarction in Korea: Korean Health Insurance Review and Assessment Data

Choongki Kim; Dong Ho Shin; Chul Min Ahn; Jung-Sun Kim; Byeong Keuk Kim; Young Guk Ko; Donghoon Choi; Myeong Ki Hong; Juhee Park; Hyeyeong Lee; Yoon Jung Choi; Youn Song Choi; Sang Kwon Oh; Yangsoo Jang

Background and Objectives Despite the favorable efficacy of new antiplatelet agents demonstrated in randomized controlled trials, their clinical implications in Korea are unclear. The purpose of this study was to investigate trends in antiplatelet agent use for acute myocardial infarction (AMI) and their impact on 30-day clinical outcomes. Methods AMI patients undergoing percutaneous coronary intervention between 2010 and 2015 were assessed using claim data from the Health Insurance Review and Assessment Service. Results The use of new antiplatelet agents has rapidly increased since 2013 and has been preferred over clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals) since 2015. Both prasugrel (Effient; Eli Lilly and Company) (odds ratio [OR], 0.45; 95% confidence interval [CI], 0.31–0.67; p<0.001) and ticagrelor (Brilinta; AstraZeneca Pharmaceuticals LP) (OR, 0.84; 95% CI, 0.71–0.98; p=0.032) had an independent effect on lowering 30-day mortality in a weighted multivariable logistic regression model. However, new antiplatelet agents had no significant effect on other clinical outcomes including myocardial infarction, stroke, bleeding, and readmission within 30 days. Conclusion The use of new antiplatelet agents is rapidly increasing, and they have been used more commonly than clopidogrel since 2015. We demonstrated that new antiplatelet agents have a favorable effect on reducing 30-day mortality in AMI patients in Korea.


The Korean journal of internal medicine | 1997

A Case of Pulmonary Siderosis

Min Soo Han; Dong Il Kim; Young Soo Cha; Jin Hwan Kook; Ki Heon Yoon; Jeung Sook Kim; Yoon Jung Choi; Hee Jeong Ahn; Bum Shik Kim


Yeungnam University Journal of Medicine | 2011

Rhabdomyolysis Induced Acute Kidney Injury in a Patient with Leptospirosis

Yoon Jung Choi; Jeung Min Park; Yo Han Jung; Jong Ho Nam; Hyun Hee Chung; Tae Woo Kim; Kyu Hyang Cho; Jun Young Do; Kyeung Woo Yun; Jong Won Park


Korean Journal of Clinical Pharmacy | 2018

Medical Utilization and Antibiotics Use of Prostatitis Patients in Korea

Boram Lee; Yoon Jung Choi; Younsong Choi; Nayoung Kong; Minsun Choi


Journal of the American College of Cardiology | 2016

ACUTE PERICARDITIS AND CARDIAC TAMPONADE WITH VERY HIGH CARCINOEMBRYONIC ANTIGEN (CEA) LEVEL RELATED WITH MEDIASTINAL CYSTIC MASS

Kang-Un Choi; Jang-Won Son; Jong Ho Nam; Byung-Jun Kim; Kyu-Hwan Park; Chan-Hee Lee; Ung Kim; Jong-Seon Park; Dong-Gu Shin; Young Jo Kim; Jeong-Hwan Cho; Yoon Jung Choi


Journal of the American College of Cardiology | 2014

TCT-638 Five-year Clinical Outcomes of Drug Eluting Stents Versus Bare Metal Stents in Patients With Large Vessel and Single Coronary Lesion

Kyu-Hwan Park; Chan-Hee Lee; Yoon Jung Choi; Tae Hun Kwon; Kanguni Choi; Jang Won Son; Sang-Hee Lee; Ung Kim; Jong Seon Park; Dong-Gu Shin; Young Jo Kim; Jeong-Hwan Cho; Sang Wook Kang; Yoon-Kyung Cho; Hyungseop Kim; Chang-Wook Nam; Seung-Ho Hur; Kwon-Bae Kim; Dong-Kie Kim; Sang-Hoon Seol; Tae-Hyun Yang


Journal of the American College of Cardiology | 2013

TCT-234 The Impact of Weekend and Holiday Versus Weekday Presentation on the Reperfusion Therapy and Clinical Outcomes in Acute Myocardial Infarction Patients

Hyun-Wook Lee; Shung Chull Chae; Myeong Chan Cho; Yoon Jung Choi; Kang Woon Choi; Taek Jong Hong; Seung-Ho Hur; Yangsoo Jang; Myung Ho Jeong; Jung Hwan Jo; Sung Yun Jung; Sang Wook Kang; Su Mi Kim; Ung Kim; Young Jo Kim; Tae Hun Kwon; Chan Hee Lee; Sang-Hee Lee; Jong Seon Park; Seung-Jung Park; Won Jong Park; Ki-Bae Seung; Dong Gu Shin; Jang Won Son; In Hwan Song; Junghan Yoon


Journal of the American College of Cardiology | 2013

TCT-233 The Effects of Statin Therapy in Patients With ST-segment Elevation Myocardial Infarction According to Complete or Incomplete Revascularization

Hyun-Wook Lee; Shung Chull Chae; In-Ho Chae; Myeong Chan Cho; Yoon Jung Choi; Taek Jong Hong; Seung-Ho Hur; Yangsoo Jang; Myung Ho Jeong; Jung Hwan Jo; Sang Wook Kang; Ung Kim; Young Jo Kim; Tae Hun Kwon; Chan Hee Lee; Sang-Hee Lee; Jong Seon Park; Seung-Jung Park; Won Jong Park; Ki-Bae Seung; Dong Gu Shin; Jang Won Son; In Hwan Song; Junghan Yoon


American Journal of Cardiology | 2013

Independent Risk Factors for in-hospital Mortality in Patients with Acute Myocardial Infarction Complicated with Cardiogenic Shock Before Primary Coronary Intervention

Yoon Jung Choi; Sang-Hee Lee; Ung Kim; Jong Seon Park; Dong Gu Shin; Young Jo Kim; Kwon Bae Kim; Hyung Seop Kim; Hyeok Jun Yoon; Jung Sook Seo; Dae Kyeong Kim; Dong Soo Kim; Pil Sang Song; Doo Il Kim

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