Yoon Jung Choi
Yeungnam University
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Featured researches published by Yoon Jung Choi.
Diabetes & Metabolism Journal | 2012
Chang Koo Lee; Yoon Jung Choi; So Young Park; Jong Yeon Kim; Kyu Chang Won; Yong Woon Kim
Background Metformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known. Methods To evaluate whether metformin induces anorexia via the hypothalamus, various concentrations of metformin were injected into the lateral ventricle of rats through a chronically implanted catheter and food intake was measured for 24 hours. The hypothalamic neuropeptides associated with regulation of food intake were also analyzed following 1 hour of intracerebroventricular (ICV) injections of metformin. Results An ICV injection of metformin decreased food intake in a dose-dependent manner in unrestrained conscious rats. Hypothalamic phosphorylated AMP-activated protein kinase (pAMPK) increased by 3 µg with metformin treatment, but there was no further increase in pAMPK with increases in metformin dosage. The hypothalamic phosphorylated signal transducer and activator of transcription 3 (pSTAT3) increased by 3 µg with metformin treatment, but, there was no further increase in pSTAT3 level following increases of metformin dosage. Hypothalamic proopiomelanocortin was elevated with metformin treatment, while neuropeptide Y was not significantly changed. Conclusion Our results suggest that metformin induces anorexia via direct action in the hypothalamus and the increase in pSTAT3, at least in part, is involved in the process. However, hypothalamic pAMPK appears not to contribute to metformin-induced appetite reduction in normal rats. Further studies exploring new pathways connecting metformin and feeding regulation are needed.
Korean Circulation Journal | 2017
Choongki Kim; Dong Ho Shin; Chul Min Ahn; Jung-Sun Kim; Byeong Keuk Kim; Young Guk Ko; Donghoon Choi; Myeong Ki Hong; Juhee Park; Hyeyeong Lee; Yoon Jung Choi; Youn Song Choi; Sang Kwon Oh; Yangsoo Jang
Background and Objectives Despite the favorable efficacy of new antiplatelet agents demonstrated in randomized controlled trials, their clinical implications in Korea are unclear. The purpose of this study was to investigate trends in antiplatelet agent use for acute myocardial infarction (AMI) and their impact on 30-day clinical outcomes. Methods AMI patients undergoing percutaneous coronary intervention between 2010 and 2015 were assessed using claim data from the Health Insurance Review and Assessment Service. Results The use of new antiplatelet agents has rapidly increased since 2013 and has been preferred over clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals) since 2015. Both prasugrel (Effient; Eli Lilly and Company) (odds ratio [OR], 0.45; 95% confidence interval [CI], 0.31–0.67; p<0.001) and ticagrelor (Brilinta; AstraZeneca Pharmaceuticals LP) (OR, 0.84; 95% CI, 0.71–0.98; p=0.032) had an independent effect on lowering 30-day mortality in a weighted multivariable logistic regression model. However, new antiplatelet agents had no significant effect on other clinical outcomes including myocardial infarction, stroke, bleeding, and readmission within 30 days. Conclusion The use of new antiplatelet agents is rapidly increasing, and they have been used more commonly than clopidogrel since 2015. We demonstrated that new antiplatelet agents have a favorable effect on reducing 30-day mortality in AMI patients in Korea.
The Korean journal of internal medicine | 1997
Min Soo Han; Dong Il Kim; Young Soo Cha; Jin Hwan Kook; Ki Heon Yoon; Jeung Sook Kim; Yoon Jung Choi; Hee Jeong Ahn; Bum Shik Kim
Yeungnam University Journal of Medicine | 2011
Yoon Jung Choi; Jeung Min Park; Yo Han Jung; Jong Ho Nam; Hyun Hee Chung; Tae Woo Kim; Kyu Hyang Cho; Jun Young Do; Kyeung Woo Yun; Jong Won Park
Korean Journal of Clinical Pharmacy | 2018
Boram Lee; Yoon Jung Choi; Younsong Choi; Nayoung Kong; Minsun Choi
Journal of the American College of Cardiology | 2016
Kang-Un Choi; Jang-Won Son; Jong Ho Nam; Byung-Jun Kim; Kyu-Hwan Park; Chan-Hee Lee; Ung Kim; Jong-Seon Park; Dong-Gu Shin; Young Jo Kim; Jeong-Hwan Cho; Yoon Jung Choi
Journal of the American College of Cardiology | 2014
Kyu-Hwan Park; Chan-Hee Lee; Yoon Jung Choi; Tae Hun Kwon; Kanguni Choi; Jang Won Son; Sang-Hee Lee; Ung Kim; Jong Seon Park; Dong-Gu Shin; Young Jo Kim; Jeong-Hwan Cho; Sang Wook Kang; Yoon-Kyung Cho; Hyungseop Kim; Chang-Wook Nam; Seung-Ho Hur; Kwon-Bae Kim; Dong-Kie Kim; Sang-Hoon Seol; Tae-Hyun Yang
Journal of the American College of Cardiology | 2013
Hyun-Wook Lee; Shung Chull Chae; Myeong Chan Cho; Yoon Jung Choi; Kang Woon Choi; Taek Jong Hong; Seung-Ho Hur; Yangsoo Jang; Myung Ho Jeong; Jung Hwan Jo; Sung Yun Jung; Sang Wook Kang; Su Mi Kim; Ung Kim; Young Jo Kim; Tae Hun Kwon; Chan Hee Lee; Sang-Hee Lee; Jong Seon Park; Seung-Jung Park; Won Jong Park; Ki-Bae Seung; Dong Gu Shin; Jang Won Son; In Hwan Song; Junghan Yoon
Journal of the American College of Cardiology | 2013
Hyun-Wook Lee; Shung Chull Chae; In-Ho Chae; Myeong Chan Cho; Yoon Jung Choi; Taek Jong Hong; Seung-Ho Hur; Yangsoo Jang; Myung Ho Jeong; Jung Hwan Jo; Sang Wook Kang; Ung Kim; Young Jo Kim; Tae Hun Kwon; Chan Hee Lee; Sang-Hee Lee; Jong Seon Park; Seung-Jung Park; Won Jong Park; Ki-Bae Seung; Dong Gu Shin; Jang Won Son; In Hwan Song; Junghan Yoon
American Journal of Cardiology | 2013
Yoon Jung Choi; Sang-Hee Lee; Ung Kim; Jong Seon Park; Dong Gu Shin; Young Jo Kim; Kwon Bae Kim; Hyung Seop Kim; Hyeok Jun Yoon; Jung Sook Seo; Dae Kyeong Kim; Dong Soo Kim; Pil Sang Song; Doo Il Kim