Yorio Naide

Changes in serum and prostatic zinc concentrations in rats after intraprostatic injection of zinc: Comparison of two forms of zinc delivery.

Background: We investigated changes in zinc concentrations in serum and prostatic tissue after an intraprostatic injection of zinc, and compared two forms of zinc delivery: solution and liposome.

A proposal of subcategorization of bacterial prostatitis: NIH category I and II diseases can be further subcategorized on analysis by therapeutic and immunological procedures

Aim:u2002 We propose preliminarily that acute (category I of the NIH consensus definition) and chronic prostatitis (category II) can be subcategorized into primary and recurrent diseases based on the precise analysis of the clinical course and the immunological parameters in prostatic secretions of our cases.

Early Prognoses of 200 Renal Allografts Harvested from Non–Heart–Beating Cadavers

When the concept of brain death is not widely accepted, the viability of renal allografts of non–heart–beating cadaveric donors is one of the serious concerns for transplant surgeons. At our center, 200 kidneys were harvested from cardiac arrest donors using the regional in situ cooling technique, and they were transplanted into recipients treated with cyclosporine (CS). The ages of donors ranged from 7 months to 67 years. At the bedside a specially designed double balloon catheter, 14F, was inserted into the aorta through the femoral artery just before or immediately after the cardiac arrest. A venous drainage tube was also placed in the vena cava. Following the cardiac arrest, both balloons of the aortic catheter were inflated, and regional in situ cooling with cold Lactate Ringers solution started using the infusion pump at 20mL/kg/min. In the OR, both kidneys were removed en bloc and preserved in Collinstype solution. They were then transplanted into 200 patients treated with CS and steroid. After the transplant operations, 33 patients (16.5%) had immediate renal function, but 14 grafts (7.0%) were not successful and the patients have never had renal function. When several factors such as donor age, warm ischemic time (WIT; 12.3 ± 14.1 minutes), in situ cooling time (IST; 78.1 ± 18.0 minutes) and total ischemic time (TIT; 619 ± 340 minutes) were associated with the post–transplant renal function, only the donor age had significant correlation both with the posttransplant dialysis period and lowest serum creatine level, as follows: 10.5 days (≤ 40 years) vs. 14.6 days (>40 years); P < 0.05, and 1.16mg/dL (≤ 30 years) vs. 1.83 mg/dL (> 50 years) P < 0.001, respectively. Our findings indicate; 1) Due to the in situ cooling technique, the renal grafts of non–heart–beating cadavers can be expected to have relatively good function in the CS–treated recipients; 2) donor age is instrumental in predicting post–transplant renal function as well as the duration of ATN; 3) WIT, 1ST and TIT have no association with the post–transplant renal function if the duration of renal ischemia is within the acceptable range.

Laboratory and Clinical Study of T-3761, a New Fluoroquinolone, in Urinary Tract Infection

Minimum inhibitory concentrations (MICs) of T-3761 against clinical isolates of P. aeruginosa were compared with those of ciprofloxacin and ofloxacin. Muller-Hinton agar (pH 7.2) and urine from a male patient with chronic complicated pyelonephritis (pH adjusted to 5.8, 6.8, or 8.0) were used for assay media. Furthermore, the effects of T-3761 and ciprofloxacin on bacterial growth in urine (pH 6.0) from the patient with chronic complicated pyelonephritis were compared. A total of 36 patients with UTI, comprising 15 with acute uncomplicated cystitis and 21 with

Clinical Studies of Cefpirome in the Treatment of Urinary Tract Infections Caused by Enterococcus faecalis

During the period June 1994 to May 1996 the clinical effectiveness, bacteriologic response, and chronologic shifts of sensitivity of E. faecalis to CPR was studied in 56 patients with complicated urinary tract infections (UTIs) considered to be caused by E. faecalis. Inclusion criteria were pyuria before treatment of

Temafloxacin in the Treatment of Chronic Bacterial Prostatitis

5 WBC/hpf and bacteriuria

Prolonged Warm Ischemia Affects Long-Term Prognosis of Kidney Transplant Allografts From Non–Heart-Beating Donors

10 CFU/mL. Eight patients were excluded because of pyuria less than 5 WBC/hpf and bacteriuria less than 10 CFU/ mL, concomitant use of another antibiotic or funguria. Forty-eight patients (34 males and 14 females) were evaluated for the clinical efficacy of CPR. Fourteen patients had long-term indwelling catheters. Fourteen patients had complicated pyelonephritis, and 34 patients had complicated cystitis. Patients received i.v. 0.5 or 1 g of CPR twice daily for more than 5 days. All cases were evaluated by response of bacteriuria and pyuria on the fifth day according to Japanese UTI criteria such as excellent, moderate, and poor (Ohkoshi 1987). Minimal inhibition concentrations (MICs) of E. faecalis to CPR, ceftazidime, piperacillin, cefpiramide, and ofloxacin were measured by Japanese standard method (Report of CJSASTB, 1990). MIC distribution of E. faecalis to CPR was compared to the results obtained from isolates in other time periods of 1987–1989.

Favorable prognosis of kidney allografts from unconditioned cadaveric donors whose procurement was initiated after cardiac arrest

19 patients (mean age 52.0 ± 9.0 years) with chronic bacterial prostatitis were treated with temafloxacin 150mg or 300mg bid for 7 to 14 (average 11.5 ± 3.48) days. Bacteriological study was by quantitative cultures of prostatic secretion (EPS) with cotton swab technique. Clinical isolates of both aerobes and anaerobes obtained by this procedure were identified, and their susceptibility to temafloxacin was determined by agar plate assay. Leucocytes were microscopically examined on EPS freshly collected soon after prostatic massage. The clinical courses of symptoms and findings after digital palpation of the prostate were assigned as parameters of evaluation.