Yoshiaki Ishiguro

Febuxostat (Feburic tablet) in the management of hyperuricemia in a general practice cohort of Japanese patients with a high prevalence of cardiovascular problems

Abstract Hyperuricemia is increasing in prevalence and this is paralleled by an increased incidence of acute gout. In addition, there is growing evidence of an association between high serum levels of uric acid (sUA) and cardiovascular disease (CVD). In this preliminary report, we present 12–16 week results from a multicenter, general practice study in which we evaluated the usefulness of febuxostat in a cohort of untreated patients with hyperuricemia with a high prevalence of CVD. Febuxostat titrated from 10 mg/day up to 40 mg/day resulted in statistically significant and clinically relevant reductions in sUA after 12–16 weeks. A “responder” level of 6.0 mg/dL or lower was achieved in 95 of 100 (95%) patients. Significant reductions in sUA were achieved regardless of the presence/absence of coexisting diseases (e.g. CVD, renal insufficiency, diabetes and obesity) or the class of antihypertensive agent being used by the patient. No serious adverse reactions were noted with febuxostat. Although allopurinol has been used generally for hyperuricemia/gout, it is excreted fully via the kidneys, restricting its use in patients with reduced renal function, and its three-times-daily administration leads to poor adherence. Based on the results of this study, febuxostat may provide an easier option than allopurinol for clinicians specializing in CVDs.

Body surface distribution of ventricular late potentila evaluated by the signal-averaged ECG mapping. (I). Studies in patients with previous myocardial infarction.

心筋梗塞症 (MI) における加算平均心電図 (SAEOG) の体表面分布を知るため, 発症後1ヵ月以上経過したMI93例 (前壁群50例: A群, 下壁群43例: I群) を対象とし, 胸背部28点よりSAECGマッピングを行い, 濾波後QRS時間 (fQRSd) の分布を検討した.各々の誘導点が有するアーチファクトや誘導部位の影響を除くため, 患者のfQRSdより健常対照11例のfQRSdの平均値を減じ, その値のばらつきの程度を標準偏差 (SD) に対する比で表し, departure ratio map (DR map) と命名した.DR mapの極大はA群, I群ともに前胸部から背部にかけて広く分布したが, A群で左胸部, I群で右胸部下部に2SD以上の極大と, 正領域に取り囲まれたように位置する負領域を有した例の心室頻拍 (VT) 合併率は有意に高かった.DR mapのかかる特定のパターンはVTの発生基盤に関係している可能性が示唆され, fQRSdの体表面分布を評価する場合, 延長領域ばかりでなくそれに囲まれた相対的短縮領域にも着目すべきことが示唆された.