Yoshiaki Okuda

Histochemical demonstration of carbonic anhydrase activity in the parietal cells of the rat stomach :relation to the secretion of HCL

The purpose of this paper is to discuss some of the morphological histological charac te r i s t ics of prot rac ted gas t r ic ulcer derived f rom surgical specimens in twenty eight cases. The histological findings in these series disclosed tha t there were considerable numbers of ulcers accompanied by t ransverse ly extending scars which could not be proved macroscopically. Out of 12 cases of pers i s ten t type, 10 showed histologically ulcers wi th l inear or t r ansve r se ly extending scars and only 2 showed round ulcers [and scars , a l though macroscopical ly round ulcers were found in 5, t r ansverse ly oval ones in 3 and l inear ones in 4. In the r ecu r ren t type, on the contrary, all 12 cases except one wi th l inear scar showed round or oval ulcers and scars both macroscopically. T he histological fea tures of ulcerous scar found in 4 cases of t rans i t iona l type were s imi la r to those of pers is tent type. It is no tewor thy to s ta te tha t the mos t of the l inear ulcers or scars were found in pers i s ten t and t rans i t iona l type of ulcers wi th only single exception in the present seires. I t has been well accepted tha t l inear ulcers are different in heal ing and we believe t ha t is t rue. But our resu l t s seem to show tha t the pers is tence of ulcers i tself will make one of the main courses for the development of l inear scars, a l though the fo rmal genesis of them is not yet solved.