Yoshiaki Yuba

Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts: Report of a Case and Review of the Literature

We present the case of a 69‐year‐old man with a subcutaneous pleomorphic hyalinizing angiectatic tumor of soft parts on the back. In addition to its rare localization, it showed unique clinical features of an exceptionally long history. Histological characteristics of this tumor showed thin‐walled angiectatic blood vessels lined with a thick eosinophilic and hyalinotic amorphous material. Tumor cells are composed of pleomorphic cells. It was surgically removed, and there was no recurrence by 11 months postoperatively.

Fibrous tumor of the breast in a postmenopausal woman receiving estrogen

Fibrous tumor of the breast is a rare, benign stromal proliferation with atrophy of the epithelial component. Almost all patients who develop fibrous tumors are premenopausal. An unusual example of fibrous tumor of the breast is reported in a 62‐year‐old postmenopausal woman. The mass, first noted 1 year previously, progressively enlarged over the year. The patient noted a history of taking exogenous estrogens for 10 years. Intense estrogen administration during the year of enlargement may be associated with accelerated growth of the tumor. In addition, positive nuclear staining for estrogen receptor antibodies in stromal cells was demonstrated by immunohistochemical methods.

Coexistence of Epstein–Barr virus-associated lymphoproliferative disorder and marginal zone B-cell lymphoma of the thymus in a patient with rheumatoid arthritis treated with methotrexate

that DLBCLs arising in these sites show decreased or absent expression of MHC-II, allowing tumour cells to escape from immune attack. By extrapolation, it is distinctly possible that lack of MHC-II on the EATL type II in this case allowed it to home-in on immuneprivileged sites, probably explaining the clinical presentation of vitreous involvement and imaging-confirmed brain involvement. Once in these sites, the lymphoma could expand unchecked, probably explaining the rapid neurological deterioration of the patient. Finally, very little is known of MHC-II down-regulation in T-cell lymphomas of all subtypes in general. In the light of the observations made in this case report, a lack of MHC-II on T-cell lymphomas may be relevant in the prediction of likely tumour behaviour, and alert the clinician to keep a close watch on immune-privileged sites (i.e. brain, eye, and testis) for post-treatment recurrences.

Pseudodysplastic regenerative mucosa associated with congenital ileal atresia

A male neonate was clinically diagnosed with congenital intestinal atresia. Surgical operation was performed and the ileum including the atretic portion was resected. Grossly, there was a plaque‐like elevation of mucosa at the proximal side of the ileal atresia. Microscopic examination of this lesion revealed proliferation of severely atypical glands. Although dysplasia was a serious diagnostic concern, we concluded that ischemia due to the intestinal atresia induced this benign pseudodysplastic regenerative mucosa, judging from the pattern of coexisting inflammation and the literature review.