Yoshie Shimura | Researchain

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Featured researches published by Yoshie Shimura.

Hormone Research in Paediatrics | 1999

Association of angiotensin-converting enzyme gene polymorphism with lipid profiles in children and adolescents with insulin-dependent diabetes mellitus.

Kisho Kobayashi; Shin Amemiya; Mie Mochizuki; Koji Kobayashi; Kyoko Matsushita; Emi Sawanobori; Toshihide Ishihara; Kosuke Higashida; Yoshie Shimura; Kiyohiko Kato; Shinpei Nakazawa

We attempted to clarify the association between angiotensin-converting enzyme (ACE) gene polymorphism and the other predictive factors for macroangiopathy in children and adolescents with uncomplicated insulin-dependent diabetes mellitus (IDDM). Sixty-three patients were divided into 3 groups according to the ACE genotypes. The lipid profiles were evaluated according to ACE genotypes. The level of lipoprotein(a) (Lp(a)) in the II genotype was significantly lower than that in groups with the D allele. Lp(a) significantly correlated with apo B/apo A-I (p < 0.001, r = 0.63) and atherogenic index (AI = (total cholesterol – high-density lipoprotein cholesterol)/high-density lipoprotein cholesterol; p = 0.004, r = 0.36). We suggest that the D allele may affect the level of Lp(a) and the other lipid profiles in IDDM.

Diabetes Care | 2003

Association of the CTLA-4 Gene 49 A/G Polymorphism With Type 1 Diabetes and Autoimmune Thyroid Disease in Japanese Children

Mie Mochizuki; Shin Amemiya; Kisho Kobayashi; Koji Kobayashi; Yoshie Shimura; Toshihide Ishihara; Yoshiko Nakagomi; Kazumichi Onigata; Shinya Tamai; Akira Kasuga; Shinpei Nanazawa

Human Genetics | 2003

Functional polymorphisms in the mineralocorticoid receptor and amirolide-sensitive sodium channel genes in a patient with sporadic pseudohypoaldosteronism

Keiko Arai; Yoshiko Nakagomi; Mitsue Iketani; Yoshie Shimura; Shin Amemiya; Kenji Ohyama; Tamotsu Shibasaki

Endocrine Journal | 1995

Effects of Growth Hormone and Insulin-Like Growth Factor I on Testosterone Secretion in Premature Male Rats.

Kenji Ohyama; Masanori Ohta; Yoshiko Nakagomi; Toshitsugu Yamori; Tomoaki Sano; Yoshie Shimura; Kazumasa Sato; Shinpei Nakazawa

Endocrine Journal | 2002

Effects of Growth Hormone on Testicular Dysfunction Induced by Cyclophosphamide (CP) in GH-Deficient Rats

Kazumasa Satoh; Kenji Ohyama; Yoshiko Nakagomi; Masanori Ohta; Yoshie Shimura; Tomoaki Sano; Hiromichi Ishikawa; S Amemiya; Shinpei Nakazawa

Endocrine Journal | 1999

Growth Hormone Advances Spermatogenesis in Premature Rats Treated with Gonadotropin-Releasing Hormone Agonist.

Kenji Ohyama; Noritaka Iwatani; Yoshiko Nakagomi; Masanori Ohta; Yoshie Shimura; Tomoaki Sano; Kazumasa Sato; Rika Ohno; Hiroyo Mabe; Hiromichi Ishikawa; Shinpei Nakazawa

Journal of Veterinary Medical Science | 2007