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Dive into the research topics where Yoshie Yoshikawa is active.

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Featured researches published by Yoshie Yoshikawa.


Japanese Journal of Cancer Research | 2000

Isolation of two novel genes, down-regulated in gastric cancer.

Yoshie Yoshikawa; Hiroyuki Mukai; Fumitsugu Hino; Kiyozo Asada; Ikunoshin Kato

Using a differential display technique, we identified two genes that are down‐regulated in human gastric cancer tissue as compared to normal gastric mucosa. The down‐regulated expression of these genes in gastric cancer tissue was confirmed by northern blotting analysis and RT‐PCR. One, CA11, was a novel gene expressed predominantly in the stomach and was depleted in all of the gastric cancer cell lines examined. The other gene, GC36, was homologous to the digestive tract‐specific calpain gene, nCL‐4. The expression of both GC36 and nCL‐4 was suppressed or depleted in gastric cancer cell lines of differentiated and poorly differentiated types. This is the first report of genes, the expression of which is down‐regulated with considerable frequency in gastric cancer.


The Journal of Antibiotics | 1993

BIOLOGICAL PROPERTIES OF AUREOBASIDIN A, A CYCLIC DEPSIPEPTIDE ANTIFUNGAL ANTIBIOTIC

Kazutoh Takesako; Hiroyuki Kuroda; Toshiaki Ino-ue; Fumiyo Haruna; Yoshie Yoshikawa; Ikunoshin Kato; Katsuhisa Uchida; Tamio Hiratani; Hideyo Yamaguchi


Analytical Biochemistry | 1998

DIFFERENTIAL DISPLAY WITH CARBOXY-X-RHODAMINE-LABELED PRIMERS AND THE SELECTION OF DIFFERENTIALLY AMPLIFIED CDNA FRAGMENTS WITHOUT CLONING

Yoshie Yoshikawa; Hiroyuki Mukai; Kiyozou Asada; Fumitsugu Hino; Ikunoshin Kato


The Journal of Antibiotics | 1987

OF4949, new inhibitors of aminopeptidase B. V: Effect on the murine immune system

Susumu Sano; Hiroyuki Kuroda; Mitsuhiro Ueno; Yoshie Yoshikawa; Teruya Nakamura; Akira Obayashi


Archive | 2002

Cancer-associated genes

Yoshie Yoshikawa; Hiroyuki Mukai; Kiyozo Asada; Fumitsugu Hino; Ikunoshin Kato


The Journal of Antibiotics | 1993

Isolation, structures, and antifungal activities of new aureobasidins.

Yoshie Yoshikawa; Katsushige Ikai; Yoshihisa Umeda; Atsuko Ogawa; Kazutoh Takesako; Ikunoshin Kato; Hiroshi Naganawa


The Journal of Antibiotics | 1987

OF4949, new inhibitors of aminopeptidase B. IV. Effects of OF4949 and its derivatives on enzyme systems.

Susumu Sano; Katsushige Ikai; Yoshie Yoshikawa; Teruya Nakamura; Akira Obayashi


The Journal of Antibiotics | 1996

Precursor Directed Biosynthesis of Aureobasidins

Kazutoh Takesako; Shigetoshi Mizutani; Hitoshi Sakakibara; Masahiro Endo; Yoshie Yoshikawa; Tomoko Masuda; Elko Sono-Koyama; Ikunoshin Kato


The Journal of Antibiotics | 1988

In vivo effects of deoxyspergualin (NKT-01) on lymphocyte activation in response to alloantigens

Yoshie Yoshikawa; Uchida H; Hiroyuki Kuroda; Teruya Nakamura; Akira Obayashi; Akio Fujii; Tomio Takeuchi


Archive | 1997

PHYSIOLOGICALLY ACTIVE SUBSTANCES TKR1785'S, PROCESS FOR THE PREPARATION THEREOF, AND MICROBE

Kazutoh Takesako; Naoyuki Awadu; Yoshie Yoshikawa; Eiko Koyama; Ikunoshin Kato

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Kazutoh Takesako

Center for Cell and Gene Therapy

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Kiyozo Asada

National Institute of Genetics

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Junichi Mineno

Nara Institute of Science and Technology

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Kazutoh Takesako

Center for Cell and Gene Therapy

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Hiroyuki Kuroda

Sapporo Medical University

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