Yoshihiro Ikemiyagi

The dominant foot affects the postural control mechanism: examination by body tracking test

Abstract Conclusion: The antero-posterior (AP) body tracking test (BTT) showed that the dominant foot could affect the tilt angle of the sway movement, delineated by primary component analysis. Differences associated with the dominant foot could represent the difference in space perception of each person. Objectives: To examine whether the dominant foot could affect the postural control mechanism using the BTT. Methods: Ninety-seven healthy participants enrolled in the study were classified into right-foot and left-foot dominance groups, and their performances were compared. For the BTT, each participant stood on a stabilometer and caught the movement of a visual target moving vertically (anterior-posterior) or horizontally by the center of pressure movement, displayed on a 14-inch screen monitor at 100 cm in front of the subject. The mean displacement angle of the obtained stabilogram was evaluated by principal component analysis. Results: The AP BTT in the right-foot dominance group showed a clockwise tilt with a mean displacement angle of 3.022 ± 3.761°, whereas the group with left-foot dominance had a modest counter-clockwise tilt with a mean displacement angle of –0.694 ± 4.497°. This difference was found to be significant by the independent t test (p < 0.0001). In the lateral BTT, the mean displacement angles were not significant.

Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in patients with allergic rhinitis

BACKGROUND Studies show that immunoglobulin E (IgE) is produced in the local nasal mucosa in allergic rhinitis patients. However, no study involved the measurement of IgE levels in the local nasal mucosal tissue in allergic rhinitis patients. This study aimed to measure the local IgE levels in the nasal mucosal tissue and to compare the levels of total IgE and specific IgEs in the serum and the inferior turbinate nasal mucosa in allergic rhinitis patients using the AlaSTAT 3gAllergy assay (Siemens Healthcare Diagnostics AG, Erlangen, Germany). METHODS Total IgE antibodies and allergen-specific IgE antibodies in each sample of nasal mucosal tissue from 11 allergic rhinitis patients were measured with the AlaSTAT 3gAllergy assay. We compared the levels of total IgE and IgEs specific for house dust (HD), mites, and cedar pollen in the serum and the inferior turbinate. RESULTS The total IgE levels and the cedar pollen-specific IgE levels in the inferior turbinate mucosal tissue correlated significantly with their respective levels in serum. The HD- and mite-specific IgE levels in the inferior turbinate mucosal tissue did not correlate significantly with their respective levels in the serum. CONCLUSIONS Our results evaluating the correlations between nasal mucosal and serum levels of antigen-specific IgE indicate that IgE produced in the nasal mucosa affects the IgE levels in the serum, especially the cedar pollen-specific IgE.

Efficacy of covering mucosal defects with polyglycolic acid sheets after ear or nose surgery.

INTRODUCTION Surgery of the ear and nose often involves drilling, resulting in exposure of the bone surfaces. Fibrin is usually used to cover the exposed bone surfaces; however, this approach may result in granulation, infection, stenosis, and adhesion. Several other methods are available for covering the exposed bone surfaces. For example, implantation of skinand fascia-free grafts (nonpedicled grafts) and pedicled mucosal flaps have been attempted and found to be very useful; however, these approaches involve a complicated and invasive technique. In this study, we report the use of polyglycolic acid (PGA) sheets (Neoveil; Gunze, Kyoto, Japan) and fibrin glue to stimulate early re-epithelization at the exposed bone surface after ear or nose surgery.

A case of refractory chronic rhinosinusitis with anti-desmoglein 3 IgG4 autoantibody

Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a systemic, refractory, chronic inflammatory disease characterized by high serum IgG4 levels and histopathological findings of IgG4-positive plasma cell infiltration and fibrosis.1,2 Although recent reports have documented cases of refractory chronic rhinosinusitis (CRS) accompanied by IgG4 infiltration (IgG4-CRS),3e5 the underlying mechanism remains unknown. Desmoglein 3 is an autoantigen of Pemphigus vulgaris (PV), an autoimmune blistering mucocutaneous disease.6 Here, for the first time, we report a case of refractory CRS with treatment-recalcitrant nasal polyposis accompanied by infiltration of IgG4 autoantibody specific for desmoglein 3. This casewas diagnosed asMikuliczs disease because of bilateral submandibular and lacrimal glands swelling. We assessed the relationship between IgG4-CRS and desmoglein 3 autoantibody. A 42-year-old male who visited outpatient clinic of our hospital complained severe nasal obstruction of both sides, and also mass lesion in bilateral submandibular regions in July 2013. Initial medical examination revealed polyps in both nasal cavities and a deviation of the nasal septum toward to the right nasal cavity. Computed tomography (CT) of the paranasal sinuses and neck revealed bilateral sinusitis and bilateral submandibular and lacrimal glands swelling. Serum IgG4 and IgG levels were 383 (normal, 4.8e105 mg/dL) and 1931 mg/dL (normal, 870e1700 mg/dL), respectively. Anti-desmoglein 1 antibody and anti-PB180 antibody were negative (<3; normal, <3); antidesmoglein 3 antibody was very high (4390; normal, <3). Eosinophil proportionwere 7830/mL and 6.3% (normal, <7%). The pharynx, oral mucosa, and skin were normal, showing no lesions by whole body CT. Endoscopic sinus surgery (ESS) and biopsy of the left side of the submandibular gland under general anesthesia were performed in January 2015. The patient was then prescribed an antihistaminic agent and a nasal steroid spray. Although the nasal and paranasal mucosa showed slight swelling after ESS, the nasal condition improved and has remained healthy during follow up. Nasal and paranasal sinus mucosa and submandibular gland tissue obtained during surgery were fixed in neutral-buffered formalin, embedded in paraffin, and sectioned. Immunohistochemical staining was performed with mouse anti-human desmoglein 3 (Hycult Biotech, The Netherlands) and mouse anti-human IgG4

A Case Report of Facial Nerve Palsy in Childhood Associated with Chickenpox

Chickenpox is one of the most frequent infectious diseases during childhood. However, instances of this disorder being complicated by facial paralysis alone are rare. In a 4-year-old girl, chickenpox-related exanthema appeared. Thereafter, right facial movements became impaired, and the girl was diagnosed with facial paralysis. There were no other neurological abnormalities. After 6 weeks of steroid therapy, a complete response was achieved.