Yoshihiro Noso

Disorder of Endothelia Vessels` Functional State with Malignant Tumors in Patients Exposed Anthropogenic Radiation

The aim of this research is to determine the characteristics of endothelial factors and the hemostatic system conditions with malignant neoplasms patients, which were exposed to ionizing radiation. Total number of examined people is 223, 153 of them are patients with gastrointestinal tract oncopathology. The article presents the results of the analysis of numerical indicators of endothelial condition and platelet hemostasis of patients, who had cancer. They lived in the regions of Kazakhstan, subjected to contamination of radionuclides as a result of nuclear weapons tests, which took place in this region from 1949 to 1989. These results then were compared to cancer patients and healthy individuals with no radiation risk. The study revealed the presence of higher levels of endothelial dysfunction and following trigger of the hemostatic system in patients with malignant tumors of the gastrointestinal tract. In particular, the defined high degree of endothelial dysfunction include endothelium- dependent vasodilation, content desquamated endothelial cells in peripheral blood and von Willebrand factor. These indicators have a clear correlation with the degree of disorder of studied parameters of the hemostasis, which can cause the development of thrombotic complications.

The current state of accidents involving choking on mochi (glutinous rice cakes) during New Year's in Japan and measures to prevent them: a study focusing on the elderly

• This report has discussed accident trends related to choking on mochi and measures to prevent those accidents.

Endothelial dysfunction in rectal cancer patients chronically exposed to ionizing radiation

We sought to identify the features of endothelial function in rectal cancer patients who were exposed to chronic ionizing radiation from a nuclear test site in Kazakhstan. We examined 146 individuals, 76 of whom were rectal cancer patients. The existence of a complex of disturbances of the endothelium and hemostasis systems in patients vs non-patients was revealed. Endothelial dysfunction was expressed as an increase of nitric oxide (NO) production along with decreases in vasodilatation function, and increased levels of von Willebrand factor in blood, along with an increase in the number of circulating endotheliocytes. Significant correlations between indicators of endothelial function and vascular-platelet hemostasis were observed. These changes and their interrelations were expressed more strongly in the patients who lived in the contaminated area around the nuclear test site. Such patients could have an increased risk of thrombosis and other complications after the treatment of a malignant neoplasm.

Epidemiological Characteristics of Disaster-related Suicides in the34 Years since the Great East Japan Earthquake

The Great East Japan Earthquake struck Japan with a magnitude of 9.0 at 2:46 PM on March 11, 2011. Five years have passed since the earthquake and subsequent tsunami struck, but the mental and physical care of the victims, the livelihoods of those affected, and the economic impact of the disaster continue to cause social concern (Orui, Harada, & Hayashi, 2014; Tokuzu, Ouchi, Kikuchi & Konno, et al., 2015; Yabuki, Ouchi, Kikuchi & Konno, 2015; Hara, 2015). Over the past few years, research has examined the effects of the disaster on the cognitive function of the elderly (Ishiki et al., 2016), and one study suggested that oxidative stress may be associated with disaster-related hypertension (DRH) in individuals exhibiting effects of the Great East Japan Earthquake (Shiraishi et al., 2016).

A Study of the Relationship between Japans Suicide Rate and the Spring Wage Increase over a Period of 34 Years: Devising Future Suicide Prevention Measures for Various Countries and Examining Numerous Issues Related to Suicide

Japan had around 20,000 suicides in the early 1990s, but the annual number of suicides increased abruptly to over 30,000 in 1998. Devising and implementing suicide prevention measures to reduce the number of suicides has become a societal issue that Japan should promptly address. Over the past few years, suicides in Japan have decreased, but the suicide rate in Japan remains high in comparison to the rest of the world. We believe that clearly identifying factors and issues related to suicide and implementing specific preventive measures to address those factors are crucial to preventing suicide. The current study examines the relationship between suicide and financial issues over a prolonged period. Specifically, it examines the annual suicide rate (per 100,000 populations) during 1980–2013 and the spring wage increase (%) at major companies in Japan during the same period. This study examines suicide rate and spring wage increase statistics in detail. We found the spring wage increase may be related to the overall (both-gender) suicide rate. Closer examination suggested that the spring wage increase is related to the suicide rate among males but not among females. Financial hardships and financial difficulties can lead to mental exhaustion and stress. A key measure to preventing suicide due to financial reasons is providing mental health support to individuals facing financial problems. Suicide prevention measures should be coordinated by relevant bodies and the community. Such efforts in Japan and elsewhere around the world should be based on statistical analysis of the factors involved in suicide.

International Medical Cooperation for the Radiation Exposed Population (Hibakusha) in Semipalatinsk, Kazakhstan: A Challenge from Hiroshima, the City of the World's First Atomic Bombing

The main objective of this report is to describe the activities of a non-governmental organization (NGO), the Hiroshima Semipalatinsk Project (hereafter the Hiro-Semi Project or the Project), that supports medical aid to those who were exposed to radiation from the nuclear bomb tests in Kazakhstan. The Project has carried out medical cooperation activities five times and dispatched medical missions of doctors, nurses, and medical technicians four times. In this report, we attempt to show the purpose of the