Yoshihiro Takishita

Comparison of Cisplatin plus Vindesine with Cisplatin plus Mitomycin C for Treatment of Advanced Non-Small-Cell Lung Cancer

Seventy-six patients with advanced non-small-cell lung cancer were randomly allocated to two groups and treated with cisplatin (CDDP; 80 mg/m2 on day 1) plus either vindesine (VDS; 3 mg/m2 on days 1 and 8) or mitomycin C (MMC; 8 mg/m2 on days 1 and 8) every 3-4 weeks. The objective response rates were 26% (10/38) for CDDP plus VDS and 32% (11/34) for CDDP plus MMC; the corresponding response rates in patients with adenocarcinoma were 7% (1/14) and 43% (6/14), respectively. The median survival times of patients treated with CDDP plus VDS and CDDP plus MMC were 33 and 30 weeks, respectively, the difference in survival times in the two groups not being significant. There was no significant difference in toxic effects in the two groups except that alopecia and leukopenia were more frequent in patients treated with CDDP plus VDS.

A case of portal hypertension of vinyl chloride worker

塩化ビニール・モノマーの暴露が関係していると思われる門脈圧亢進症の1例について報告する. 症例は38歳の男性で,18年9カ月間にわたり塩化ビニール製造作業に従事していたが,脾腫,食道および胃の静脈瘤を伴う門脈圧亢進症と診断され脾摘出術および食道離断術を受けた.術前の検査では血小板数の減少,ICGおよびBSPによる色素排泄能の障害が認められたが,GOT,GPT,およびアルカリフォスファターゼ値は正常であった.肝の組織学的検査では門脈域の線維化が著しく,小葉間におよぶ線維性の隔壁があり,類洞内皮細胞の僅かな増加がみられた.摘出脾では著明な慢性うっ血像を示し,脾洞の増生,髄索および血管周囲の線維化がみられた.患者は術後8カ月目に絞拒性腸閉塞で同部の切除術を受けたが,術後に腎不全および汎発性腹膜炎で死亡した.