Yoshimasa Nakano
Otsuka Pharmaceutical
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Yoshimasa Nakano.
Microbiology and Immunology | 1980
Wasei Miyazaki; Hisashi Tamaoka; Masanao Shinohara; Hirotsugu Kaise; Taketoshi Izawa; Yoshimasa Nakano; Taroh Kinoshita; Kyongsu Hong; Kozo Inoue
A complement inhibitor, K‐76, was isolated and purified from the culture supernatant of a fungus, Stachybotrys complementi, nov. sp. K‐76, isolated from soil of Ishigaki Island, Okinawa. K‐76 is a sesquiterpene compound and it can be oxidized to a monocarboxylic derivative (K‐76 COOH), the sodium salt of which is very soluble and much less toxic than K‐76. K‐76 and K‐76 COOH both inhibited complement activation by either the classical or alternative pathway. They inhibited generation of the factor chemotactic to human polymorphonuclear leukocytes from human serum by aggregated immunoglobulin. When sensitized erythrocytes were treated with complement in the presence of K‐76 COOH, the resulting unlysed cells were found to be in the state of EAC1, 4b, 2a, 3b. Thus K‐76 COOH is considered to block mainly the C5 intermediate step. K‐76 COOH did not inhibit any proteases or esterases tested, except when tested at high concentration.
Journal of The Chemical Society, Chemical Communications | 1979
Hirotsugu Kaise; Masanao Shinohara; Wasei Miyazaki; Taketoshi Izawa; Yoshimasa Nakano; Michiharu Sugawara; Kimio Sugiura; Kyoyu Sasaki
The structure of ‘K-76’(1), a complement inhibitor containing a spirobenzofuran unit, obtained from Stachybotrys complementi nov. sp. K-76, is reported.
Pathology International | 2008
Yoshimasa Nakano; Takahiro Hirano; Kenji Uehara; Seiji Nishibayashi; Katsuji Hattori; Miki Aihara; Yoshihisa Yamada
The aim of the present study was to introduce a new anti‐glomerular basement membrane nephritis model in which plasma creatinine levels dramatically increased only 4 weeks after a single administration of rabbit antirat glomerular basement membrane antibody in Sprague–Dawley rats. According to renal morphology, glomerular lesions characterized by mesangial expansion and adhesion of the glomerular tuft to Bowmans capsule were observed in the early stage at day 7 after disease induction; adhesion was detected in approximately 90% of glomeruli 14 days after antibody injection. After 21 days the rats exhibited pronounced glomerulosclerosis/hyalinosis and severe tubulointerstitial lesions characterized by interstitial fibrosis. Urinary podocytes excreted in nephritis rats were studied and it was found that urinary podocyte loss might be closely related to progression of renal injury. Because this new model simply and reproducibly demonstrates development of end‐stage renal disease, it will be beneficial for elucidating mechanisms by which chronic renal injury irreversibly progresses, as well as for developing therapeutic agents for chronic renal failure.
Archive | 1990
Hitoshi Tone; Seiji Sato; Hideaki Sato; Katsumi Tamura; Shigeharu Tamada; Kazumi Kondo; Tomoyuki Kawaguchi; Yoshimasa Nakano; Masahiro Murakami; Yoshihiko Kitayamasukaihaitsu Ito; Yasuyuki Kamiichi Chome Kita; Shuji Hiyoshidai Yonbancho Akai; Hiromichi Fujioka; Yasumitsu Tamura; Katsuhide Matoba; Youichi Taniguchi; Shinji Nishitani; Satoshi Hayakawa; Toshinori Kaneyasu
The Journal of Antibiotics | 1991
Yoshimasa Nakano; Tomoyuki Kawaguchi; Junko Sumitomo; Taeko Takizawa; Setsuyoshi Uetsuki; Michiharu Sugawara; Masaru Kido
Thrombosis and Haemostasis | 1986
Nakayama Y; Masanao Shinohara; Tani T; Kawaguchi T; Furuta T; Taketoshi Izawa; Hirotsugu Kaise; Wasei Miyazaki; Yoshimasa Nakano
Archive | 1978
Wasei Miyazaki; Hirotsugu Kaise; Yoshimasa Nakano; Taketoshi Izawa; Yasuo Oshiro; Masanao Shinohara
Experimental Animals | 2010
Seiji Nishibayashi; Katsuji Hattori; Takahiro Hirano; Kenji Uehara; Yoshimasa Nakano; Miki Aihara; Yoshihisa Yamada; Masahiro Muraguchi; Fusako Iwata; Yoshiharu Takiguchi
Archive | 1994
Hitoshi Tone; Masatoshi Morisue; Katsumi Tamura; Toshiki Miyazaki; Yoshimasa Nakano
Archive | 1979
Masanao Shinohara; Yoshimasa Nakano; Hirotsugu Kaise; Taketoshi Izawa; Wasei Miyazaki