Yoshinori Nio

BRAF and K-ras gene mutations in human pancreatic cancers

We investigated the frequency of BRAF mutations in human pancreatic cancer specimens to determine its role in the development of pancreatic cancer. Nine pancreatic cancer samples without a K-ras codon 12 mutation and 19 with a K-ras mutation were included in the study. Analyses of the BRAF sequence revealed mutations in exon 15 (V599E) in two cases, both of which also exhibited a K-ras codon 12 mutation. No BRAF mutation was found in cases without a K-ras mutation. The BRAF V599E mutation was not found to be a major mutation in pancreatic cancers that had no K-ras codon 12 mutation.

Case report of xanthogranulomatous cholecystitis accompanied by Mirizzi syndrome

Xanthogranulomatous cholecystitis (XGC) is a rare type of inflammatory disease of the gallbladder; this entity has also been termed fibroxanthogranulomatous inflammation, and ceroid or ceroid-like histiocytic granuloma of the gallbladder. Clinically, XGC sometimes is confused with a malignant neoplasm. Recently, we encountered a patient with XGC and Mirizzi syndrome, which was difficult to differentiate from gallbladder cancer accompanied by obstructive jaundice. It is important to realize that, pathologically, XGC is a benign disease, but that, in some cases, patients manifest an unusual clinical course.

A case report of acute phlegmonous gastritis after gastric operation

We present a patient with acute phlegmonous gastritis after a gastric operation. The patient underwent subtotal gastrectomy and lymph node dissection following the diagnosis of early gastric cancer. T

Clinical Evaluation of Terbutaline Sulfate as a Potential Agent for Treating Anastomotic Leakage after Gastric Operation: Effect of Terbutaline Sulfate on Pancreatic Exocrine Secretion

Clinical advantage of terbutaline sulfate (Bricanyl®) was evaluated in 6 patients with anastomotic leakage after gastric operation. Terbutaline sulfate was administered subcutaneously for the purpose