Yoshio Akiyama
University of California, Los Angeles
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Featured researches published by Yoshio Akiyama.
Developmental Medicine & Child Neurology | 2008
Arthur H. Parmelee; Waldemar H. Wenner; Yoshio Akiyama; Marvin A. Schultz; Evelyn Stern
Suggestions that rapid eye movement (REM) sleep is ontogenetically primitive and observations of the behaviour of premature infants led to an attempt to trace the development of sleep in human infants from the premature period to three months after the expected date of delivery.
Electroencephalography and Clinical Neurophysiology | 1968
Arthur H. Parmelee; Schulte Fj; Yoshio Akiyama; Waldemar H. Wenner; Marvin A. Schultz; Evelyn Stern
Abstract 1. 1. Repeated polygraphic recording of long duration were made of seventeen premature, ten full-term, and five suspected small-for-dates infants. Besides EEG, these recordings included observation of behavior and monitoring of multiple physiological parameters. 2. 2. A 3-digit code was devised for EEG patterns of infants between 28 and 40 weeks conceptional age. The first 2 digits represent the conceptional age at which a variation on the basic pattern, identified by the third digit, generally occurs. The age designations of the code system were substantiated by the distributions of EEG patterns found in records at different conceptional ages. In addition, use of the coding system differentiated small-for-dates infants from prematures. 3. 3. The observations and physiological data were used in defining 2 sleep states: quiet sleep and active sleep. Examination of the distributions of EEG patterns within each state indicated progressively distinct relationships between state and EEG pattern with maturation. Determination of conceptional age and neurological maturation was based on these relationships.
Experimental Neurology | 1969
Arthur H. Parmelee; Yoshio Akiyama; Evelyn Stern; Margaret Harris
Abstract In premature and full-term infants the EEG during quiet sleep is characterized by bursts of large amplitude slow waves with superimposed rapid rhythms, alternating with attenuated periods of mixed frequencies. To trace the ontogenetic development of this pattern, the duration of the large amplitude activity (bursts) and attenuated periods (flats) was measured in recordings done at 29, 33, and 40 weeks conceptional age in premature infants and at 40 weeks in full-term and trisomy-21 (Downs syndrome) infants. All age-related changes were statistically significant. Between 29 and 40 weeks the length of the burst increased from 3.3 to 5.9 sec, the flat decreased from 9.3 to 4.4 sec, and the complete burst-flat unit decreased from 12.6 to 10.3 sec. The only difference between the groups occurred in the duration of bursts, which were longer in the prematures recorded at 40 weeks. Full-term and trisomy-21 infants of the same age showed no differences. The age changes were primarily due to numerous very long burst-to-burst intervals in the small premature infants. The modal interval at all ages was 9 sec, which suggests the presence of a central pacemaker that is not altered by maturation during intrauterine development. Consideration of parallels between EEG of immature animals and human infants led to the hypothesis that continuity of EEG activity (increasing burst length) is a function of cortical maturation involving increases in the complexity of interneuronal interaction and feedback circuits.
Electroencephalography and Clinical Neurophysiology | 1969
Yoshio Akiyama; Schulte Fj; Marvin A. Schultz; A.H Parmelle
Abstract Utilizing a computer of average transients, acoustic summated evoked responses were obtained from premature, full term, and hypoxic infants, during specific states of sleep, monitored polygraphically during natural sleep. Characteristic peaks were present in greater detail in the normal full term infants during Quiet Sleep as compared to the prematures and hypoxic infants, but diminished in amplitude during Active Sleep. The patterns of the peaks in the acoustic evoked response (AER) were a better indicator of conceptional age than the latencies. The variability of the AER was shown to be related to the background EEG. For this reason, monitoring the sleep states polygraphically to insure standardization of technique is necessary before meaningful results can be obtained. The AER is another technique for exploring the neurological integrity of the newly born infant.
Electroencephalography and Clinical Neurophysiology | 1968
Marvin A. Schultz; Schulte Fj; Yoshio Akiyama; Arthur H. Parmelee
Abstract The EEG development of sigma rhythm (sleep spindles) has been studied in normal and hypothyroid infants. Work by others in infant animals has shown that there is a close relationship between the appearance of this rhythm and brain maturation. In this study, all hypothyroid infants initially showed a decrease from normal or an absence of sigma rhythm. After thyroid therapy some developed normal amounts of this activity but others continued to show less sigma rhythm than control infants. Those infants that developed normal sigma rhythm activity tended to demonstrate normal developmental quotients on follow-up evaluation, whereas those that did not showed lower developmental quotients. The results show that in cretinism there is a delay in the bioelectric and neurophysiological development of the brain and suggest that in some cases there is a continued deficit of neuronal function or integration after treatment with thyroid hormone.
Developmental Medicine & Child Neurology | 2008
Paul Casaer; Yoshio Akiyama
Both the age of the infant and the birthweight in relation to age are relevant factors in studying prenatal and neonatal physiology and in evaluating immediate and future clinical risks to the fetus and the newborn.
The Journal of Pediatrics | 1964
Yoshio Akiyama; Arthur H. Parmelee; Jenny Flescher
Review of the electroencephalograms of visually handicapped children revealed a greater frequency of abnormalities in the totally blind children as compared to the partially sighted children. The abnormalities noted were spikes and slow waves and absence of alpha rhythm activity over the occipital areas. There were no correlations between the degree of abnormality of the EEG and the intellectual potential or presence of seizures. The electrical abnormalities may represent a dysfunction of the normal neurophysiologic relationship within the brain because of absence of or deprivation of a significant sensory input.
Pediatrics | 1969
Evelyn Stern; Arthur H. Parmelee; Yoshio Akiyama; Marvin A. Schultz; Waldemar H. Wenner
Electroencephalography and Clinical Neurophysiology | 1967
Arthur H. Parmelee; Yoshio Akiyama; Schulte Fj
Acta paediatrica Belgica | 1973
Paul Casaer; Yoshio Akiyama