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Archive | 1976

Life Prolongation of Mice Bearing Syngeneic Tumor, Leukemia P388 with the Streptococcal Preparation, OK-432 and Its Mechanism of Action

Takao Iwaguchi; Yoshio Sakurai

Intraperitoneal administration of OK-432 prolonged life span of CDF1 mice bearing P388. Cell-mediated immune response of the host was investigated in vitro with the method of electrophoretic mobility of macrophage. At the early stage of tumor development, the cell-mediated immune response of the host treated with OK-432 was kept stronger than that of the untreated one. However, at the advanced stage of tumor development, there was little difference in the cell mediated immune response between both groups. The host was found to be more immunosuppressed than that at the early stage of tumor development.


GANN Japanese Journal of Cancer Research | 1965

A NEW ALKYLATING ANTITUMOR AGENT EFFECTIVE ON EXPERIMENTAL TUMORS RESISTANT TO NITROGEN MUSTARD

Mahmoud M. El-MERZABANI; Yoshio Sakurai


GANN Japanese Journal of Cancer Research | 1965

Inhibition of tumor growth by new sulfonic acid esters of aminoglycols.

Mahmoud M. El-MERZABANI; Yoshio Sakurai


GANN Japanese Journal of Cancer Research | 1972

SENSITIVITY OF TRANSPLANTABLE RAT LEUKEMIA, DBLA-6, TO ANTITUMOR AGENTS

Michiko Aoshima; Yoshio Sakurai


GANN Japanese Journal of Cancer Research | 1967

ANTICANCER ACTIVITIES OF METHANESULFONIC ACID ESTERS OF AMINOGLYCOLS AGAINST MOUSE LEUKEMIA L-1210

Mahmoud M. El-MERZABANI; Yoshio Sakurai


GANN Japanese Journal of Cancer Research | 1971

COMPARATIVE STUDIES ON BIOLOGICAL CHARACTERISTICS OF TRANSPLANTABLE RAT LEUKEMIA, DBLA LINES

Michiko Aoshima; M. Ishidate; Yoshio Sakurai


GANN Japanese Journal of Cancer Research | 1970

PERITONEAL BLEEDING IN NORMAL RAT INDUCED BY LYOPHILIZED POWDER OF TUMOR CELLS

Takao Iwaguchi; Yoshio Sakurai


GANN Japanese Journal of Cancer Research | 1973

Comparative effect of vincristine and alkylating agent No. 864 on rat leukemia in relation to the distribution of drugs and leukemic cells.

Michiko Aoshima; Yoshio Sakurai


GANN Japanese Journal of Cancer Research | 1973

TUMOR INHIBITORY EFFECT OF A NEW SERIES OF METHANESULFONATE OF AMINOGLYCOLS

Mahmoud Mohamed El-Merzabani; Hiroko Ichimura; Hiroshi Satoh; Yoshio Sakurai


GANN Japanese Journal of Cancer Research | 1973

A NEW BIOASSAY METHOD FOR VINCRISTINE IN ANIMAL TISSUES

Michiko Aoshima; Yoshio Sakurai

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