Publication


Featured researches published by Yoshio Urawa.


Tetrahedron Letters | 2003

A convenient method for preparing aromatic ketones from acyl chlorides and arylboronic acids via Suzuki–Miyaura type coupling reaction

Yoshio Urawa; Katsuyuki Ogura

Abstract Aromatic ketones are synthesized efficiently via palladium-catalyzed cross-coupling reaction of boronic acids with acyl chlorides in the presence of K 3 PO 4 hydrate in toluene. This allows the use of aliphatic acyl chlorides as the starting material. Hydrated water plays a significant role as an H 2 O source to activate the catalytic system.


Journal of Organometallic Chemistry | 2002

Investigations into the Suzuki–Miyaura coupling aiming at multikilogram synthesis of E2040 using (o-cyanophenyl)boronic esters

Yoshio Urawa; Hiroyuki Naka; Mamoru Miyazawa; Shigeru Souda; Katsuyuki Ogura

Abstract The Suzuki–Miyaura cross-coupling reaction between 1-{3-bromo-4-chloro-5-[1-( R )-fluoropropyl]}phenylpiperazine (( R )- 1b ) and thermally unstable ( o -cyanophenyl)boronic ester 6b in the presence of dichlorobis(triphenylphosphine)palladium and potassium phosphate hydrate in boiling toluene was found to afford 1-{3-(2-cyanophenyl)-4-chloro-5-[1-( R )-fluoropropyl]}phenylpiperazine (( R )- 5 ), an intermediate for the synthesis of E2040, in excellent yields. The reaction conditions for the cross-coupling were optimized by the design of experiments (DOE) approach and found to be applicable to electron-rich and/or sterically hindered aryl bromides. Safety evaluation for the production of ( R )- 5 is also described.


Archive | 2001

1,2-dihydropyridine compounds, process for preparation of the same and use thereof

Satoshi Nagato; Kohshi Ueno; Koki Kawano; Yoshihiko Norimine; Koichi Ito; Takahisa Hanada; Masataka Ueno; Hiroyuki Amino; Makoto Ogo; Shinji Hatakeyama; Yoshio Urawa; Hiroyuki Naka; Anthony Groom; Leanne Rivers; Terence Smith


Organic Process Research & Development | 2003

A Novel Methodology for Efficient Removal of Residual Palladium from a Product of the Suzuki−Miyaura Coupling with Polymer-Supported Ethylenediamine Derivatives

Yoshio Urawa; Mamoru Miyazawa; Naoki Ozeki; Katsuyuki Ogura


Archive | 2009

1, 2-Dihydropyridine compounds, manufacturing method thereof and use thereof

Satoshi Nagato; Kohshi Ueno; Koki Kawano; Yoshihiko Norimine; Koichi Ito; Takahisa Hanada; Masataka Ueno; Hiroyuki Amino; Makoto Ogo; Shinji Hatakeyama; Yoshio Urawa; Hiroyuki Naka; Anthony John Groom; Leanne Rivers; Terence Smith


Archive | 2005

Crystal of 1,2-dihydropyridine compound and method for producing same

Itaru Arimoto; Satoshi Nagato; Yukiko Sugaya; Yoshio Urawa; Koichi Ito; Hiroyuki Naka; Takao Omae


Synthesis | 2003

A Convenient Method for Preparing Aromatic α,β-Unsaturated Ketones from α,β-Unsaturated Acyl Chlorides and Arylboronic Acids via Suzuki-Miyaura Type Coupling Reaction

Yoshio Urawa; Katsutoshi Nishiura; Shigeru Souda; Katsuyuki Ogura


Advanced Synthesis & Catalysis | 2004

N‐Arylation of Benzimidazole with Arylboronate, Boroxine and Boronic Acids. Acceleration with an Optimal Amount of Water

Katsutoshi Nishiura; Yoshio Urawa; Shigeru Soda


Archive | 2006

CRYSTAL OF 1,2-DIHYDROPYRIDINE COMPOUND (TYPE IV)

Yoshio Urawa; Itaru Arimoto


Archive | 1995

Process for the preparation of biphenyl containing intermediates useful in making angiotensin II receptor antagonists

Yoshio Urawa; Ken Furukawa; Toshikazu Shimizu; Yoji Yamagishi; Tomio Tsurugi; Tomio Ichino

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