Yoshiyasu Fukuyama

Polygonolide, an isocoumarin from Polygonum hydropiper possessing anti-inflammatory activity

Abstract A new isocoumarin polygonolide which inhibits the reversed passive Arthus reaction has been isolated from the methanol extract of the root of Polygonum hydropiper . The structure of polygonolide has been elucidated on the basis of spectroscopic data and confirmed to be 3,4-dimethyl-6-methoxy-8-hydroxyisocoumarin by total synthesis.

A potent cytotoxic warburganal and related drimane-type sesquiterpenoids from Polygonum hydropiper

Abstract Warburganal, a drimane-type sesquiterpene dialdehyde which has potent cytotoxic, antifeedant, antibiotic and molluscicidal activities was isolated from

Drimane-type sesqui- and norsesquiterpenoids from polygonum hydropiper

Abstract Polygonic acid, which shows weak anticomplement activity, has been isolated from leaves of Polygonum hydropiper together with four drimane-type sesquiterpenes, 11-ethoxycinnamolide, polygodial acetal, valdiviolide and fuegin and two drimane-type norsesquiterpenes, isopolygonal and polygonone.

Phthalides from the rhizome of Ligusticum wallichii

Abstract Three phthalides, 3-butylidene-7-hydroxyphthalide, and cis and trans -6,7-dihydroxyligustilides, along with a dimeric phthalide wallichilide have been isolated from the hot water extract of the rhizome of Ligusticum wallichii . Their structures were established mainly on the basis of spectroscopic data. 3-Butyl-4,5-dihydro-3-hydroxy phthalide and adenosine were identified as active principles of the extract which are responsible for increase of coronary blood flow in the dog heart.

Triterpenoid glycosides from leaves of Ilex cornuta

Abstract Two new triterpene glycosides have been isolated from the methanol extract of leaves of Ilex cornuta . Their structures were established as pomolic acid 3β- O -α- l -2-acetoxyarabinopyranosyl-28- O -β- d -glucopyranoside and 29-hydroxyoleanolic acid 3β- O -α- l -arabinopyranosyl-28- O -β- d -glucopyranoside on the basis of spectroscopic data and chemical evidence. Adenosine was identified as the active principle of the methanol extract which is responsible for the increase of coronary blood flow in the isolated blood-perfused dog heart preparation.

An acylated sitosterol glucoside from Alisma plantago-aquatica

Abstract A phytosterol glucoside acylated with stearic acid has been isolated from the methanol extract of the rhizome of Alisma Plantago-aquatica , and its

Triterpenoids from the rhizome of Alisma plantago-aquatica

Abstract Two new protostane-type triterpenes have been isolated from the methanol extract of the rhizome of Alisma plantago-aquatica . Their structures have been elucidated as 16β-methoxyalisol B monoacetate and 16β-hydroxyalisol B monoacetate mainly on the basis of spectroscopic data.