Yoshiyuki Kani

Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η1-coordination mode

Abstract We have obtained clear evidence that a copper(II)-peroxide adduct with an η1-coordination mode can cleave the C–N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase.

(2S,3R,4S,5R,6S)-6-Benzyl­oxy­methyl-4-(methoxy­methyloxy)-9-oxo-8-oxa-1-aza­bi­cyclo­[4.3.0]­nonane-2,3,5-triyl tri­acetate

The relative configuration of the title compound, C(23)H(29)NO(11), prepared in a synthetic study on the natural product sphingofungin E, has been determined. The six-membered ring adopts a chair form and the five substituents are all axial.

μ-Chloro-bis{[benzylbis(2-pyridylmethyl)amine-κ3N]chlorocopper(II)} perchlorate hemihydrate

In the title dinuclear Cu(II) compound, [Cu(2)Cl(3)(C(19)H(19)N(3))(3)]ClO(4).0.5H(2)O, the coordination geometry around the Cu atoms is square pyramidal, with the bridging Cl atom at the apical positions. The Cu-Cl-Cu angle is 136.9 (1) degrees and the Cu.Cu distance is 4.961 (1) A.

Redetermination of bis{[(2-hydroxyphenylmethyl)bis(2-pyridylmethyl)aminato]copper(II)} diperchlorate.

The structure of the title compound, [Cu(2)(C(19)H(18)N(3)O)(2)](ClO(4))(2), was reported with insufficient accuracy because of a twinning problem by Adams, Bailey, Campbell, Fenton & He [J. Chem. Soc. Dalton Trans. (1996), pp. 2233-2237]. The dinuclear phenolate-bridged Cu(II) complex has an inversion centre.

{2-[2-(Salicylideneaminomethyl)phenylimino-methyl]phenolato(2–)-N,N',O,O'}copper(II)

In the title compound, [Cu(C21H16N2O2)] or [Cu(salabza)], the six-membered diamine chelate ring moiety takes a skew-boat form with Cu—N—C—C torsion angles of −47.2 (4) and −59.6 (3)°. The geometry around the Cu atom is tetrahedrally distorted from square planar. The dihedral angle between the two CuNO planes is 29 (1)°, and those between the CuN2 and CuNO planes are 19 (1) and 21 (1)°.

(1R,2R,3S,4S)-2-[(2R,3S)-2,3-Di­methyl­oxiran-2-yl]-3,4-bis(4-methoxy­benzyl­oxy)­cyclo­hexanol

The relative configuration was determined for the title compound, C(26)H(34)O(6), which was prepared in a synthetic study on immunosuppressant FR65814. There is an intramolecular hydrogen bond between the hydroxy and epoxy groups.

micro-Chloro-bis{[benzylbis(2-pyridylmethyl)amine-kappa(3)N]chlorocopper(II)} perchlorate hemihydrate.

In the title dinuclear Cu(II) compound, [Cu(2)Cl(3)(C(19)H(19)N(3))(3)]ClO(4).0.5H(2)O, the coordination geometry around the Cu atoms is square pyramidal, with the bridging Cl atom at the apical positions. The Cu-Cl-Cu angle is 136.9 (1) degrees and the Cu.Cu distance is 4.961 (1) A.

μ-Chloro-bis{[benzylbis(2-pyridyl­methyl)­amine-κ3N]­chloro­copper(II)} perchlorate hemi­hydrate

In the title dinuclear Cu(II) compound, [Cu(2)Cl(3)(C(19)H(19)N(3))(3)]ClO(4).0.5H(2)O, the coordination geometry around the Cu atoms is square pyramidal, with the bridging Cl atom at the apical positions. The Cu-Cl-Cu angle is 136.9 (1) degrees and the Cu.Cu distance is 4.961 (1) A.