Yosuke Ando

Influence of R-CHOP Therapy on Immune System Restoration in Patients with B-Cell Lymphoma

Objective: To assess the immunosuppressive effect of R-CHOP in patients with B-cell lymphoma at 2 years. Methods: Parameters of humoral and cell-mediated immunity were assessed in 89 patients with diffuse large B-cell lymphoma or follicular lymphoma before and after 6-8 cycles of R-CHOP-14 or R-CHOP-21 regimen. Results: Data on pre- and posttreatment serum IgG (sIgG) levels were available for all 89 patients, while the corresponding data on serum CD20+, CD3+, CD4+, and CD8+ lymphocyte counts were available in only 43. Median sIgG levels significantly decreased from 1,221 mg/dl (baseline) to 733 mg/dl (after chemotherapy) (p < 0.001). Although CD20+ and CD4+ cell counts decreased (p < 0.001), no significant effect of chemotherapy on CD3+ and CD8+ cell counts was observed. CD20+ cell counts were restored to baseline levels at the 12-month follow-up. sIgG levels and CD4+ cell counts were not completely restored at 24 months, indicating a sustained immunosuppressive effect of R-CHOP in these patients. The incidence of infections over the 2-year period was 16.3-23.6%. Conclusion: The immunosuppressive effect of R-CHOP in newly diagnosed cases of B-cell lymphoma tends to persist for >2 years, although sIgG levels were restored more quickly than CD4+ cell counts.

Contents Vol. 91, 2016

A.B. Benson, Chicago, Ill. A. Chang, Singapore A.L. Cheng, Taipei J.F. Cleary, Madison, Wis. M. Dietel, Berlin P. Dufour, Strasbourg M.S. Ernstoff, Buffalo, N.Y. M.G. Fakih, Duarte, Calif. J.J. Grau, Barcelona H. Gronemeyer, Illkirch D.F. Hayes, Ann Arbor, Mich. C.S. Johnson, Buffalo, N.Y. M.J. Kelley, Durham, N.C. L. Kumar, New Delhi P.J. Loehrer, Indianapolis, Ind. J.R. Marshall, Buffalo, N.Y. S. Monfardini, Milan R. Nagler, Haifa R. Ohno, Nagoya B. Pestalozzi, Zurich H.M. Pinedo, Amsterdam E.A. Repasky, Buffalo, N.Y. A. Semczuk, Lublin E.F. Smit, Amsterdam C.N. Sternberg, Rome R. Stupp, Zurich M.S. Tallman, New York, N.Y. S. Tanaka, Hiroshima M. Tian, Houston, Tex. D.L. Trump, Buffalo, N.Y. T. Wiegel, Ulm W. Yasui, Hiroshima H. Zhang, Hangzhou City Editor-in-Chief

Acknowledgement to the Reviewers

www.karger.com/ocl Banke Agarwal, Saint Louis, Mo., USA Bharat B. Aggarwal, Houston, Tex., USA Jaffer A. Ajani, Houston, Tex., USA Salah-Eddin Al-Batram, Frankfurt a.M., Germany Roberto Angioli, Rome, Italy Jorge Aparicio, Valencia, Spain Carl Atkins, Albany, N.Y., USA Georges Azzi, Miami, Fla., USA Eishi Baba, Fukuoka, Japan Moo Jun Baek, Cheonan, Korea Lodovico Balducci, Tampa, Fla., USA Klaus H. Baumann, Marburg, Germany Wolf O. Bechstein, Frankfurt a.M., Germany Yves Bécouarn, Bordeaux, France Al B. Benson, Chicago, Ill., USA Patrick Boland, Buffalo, N.Y., USA Philip Bonomi, Chicago, Ill., USA Marius G. Bredell, Zumikon, Switzerland Fátima Carneiro, Porto, Portugal Yee Chao, Taipei, Taiwan Yao-Tseng Chen, New York, N.Y., USA Ann-Lii Cheng, Taipei, Taiwan Dennis S. Chi, New York, N.Y., USA James Cleary, Madison, Wis., USA Manola Comar, Trieste, Italy Renzo Corvò, Genoa, Italy Allan Covens, Toronto, Ont., Canada Paola Di Bonito, Rome, Italy Reinhard Dummer, Zurich, Switzerland Michael Duruisseaux, Grenoble, France Janice P. Dutcher, Bronx, N.Y., USA Monika Eichholzer, Zurich, Switzerland Bernhard J. Eigl, Vancouver, B.C., Canada Robert M. Eisele, Homburg, Germany Peter M. Ellis, Hamilton, Ont., Canada Günter Emons, Göttingen, Germany Nobuyuki Enomoto, Yamanashi, Japan Marwan G. Fakih, Duarte, Calif., USA Nicola Fazio, Milan, Italy Steven Feigenberg, Baltimore, Md., USA Clemens Feistritzer, Innsbruck, Austria Alexandra R. Fernandes, Caparica, Portugal Thiago Ferreira, Campinas, Brazil Petra Feyer, Berlin, Germany Ralph S. Freedman, Houston, Tex., USA César O. Freytes, San Antonio, Tex., USA Martin Früh, St. Gallen, Switzerland Masashi Fujii, Tokyo, Japan Val Gebski, Sydney, N.S.W., Australia Tarik Gheit, Lyon, France Alan M. Gillespie, Sheffield, UK Priscila Goncalves, Bethesda, Md., USA Juan-José Grau, Barcelona, Spain Frank Griesinger, Oldenburg, Germany Kathrin M. Gschwendtner, Freiburg, Germany Dominique Guenot, Strasbourg, France Stephan L. Haas, Stockholm, Sweden John D. Hainsworth, Nashville, Tenn., USA Shalaka Hampras, Tampa, Fla., USA Sheng-Po Hao, Taipei, Taiwan John H. Healey, New York, N.Y., USA Stephanie Hehlgans, Frankfurt a.M., Germany Masashi Hirooka, Toon, Ehime, Japan Wouter Hogendoorn, Rotterdam, The Netherlands Shigeo Horie, Tokyo, Japan Nadine Houédé, Nimes, France M.A. Huber, San Antonio, Tex., USA Jutta Hübner, Berlin, Germany Nuhad K. Ibrahim, Houston, Tex., USA Masafumi Ikeda, Chiba, Japan Misa Imai, Tokyo, Japan Takeshi Isobe, Izumo, Japan Namiki Izumi, Tokyo, Japan Long R. Jiao, London, UK Robin L. Jones, Seattle, Wash., USA Hrishi B. Joshi, Cardiff, UK Vassilos Karavassilis, Thessaloniki, Greece Shunsuke Kato, Tokyo, Japan Satoshi Kato, Morioka, Japan Nancy Kemeny, New York, N.Y., USA Hyung Jin Kim, Suwon, Korea Duck-Woo Kim, Seongnam, Korea Lee Su Kim, Ahnyang, Korea Yasushi Kojima, Shinjuku-ku, Japan Shigehiro Kokubu, Kawasaki, Japan Srinadh Komanduri, Chicago, Ill., USA Susan Krown, New York, N.Y., USA Takashi Kumada, Ogaki, Japan Takayasu Kurata, Osaka, Japan