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Featured researches published by You-Jung Kim.


Journal of Clinical Microbiology | 2006

Detection and Characterization of Bovine Coronaviruses in Fecal Specimens of Adult Cattle with Diarrhea during the Warmer Seasons

Su-Jin Park; Cheol Won Jeong; Soon-Seek Yoon; Hyoun E. Choy; Linda J. Saif; Sung-Hee Park; You-Jung Kim; Jae-Ho Jeong; Sang-Ik Park; Ha-Hyun Kim; Bong-Joo Lee; Ho-Seong Cho; Sang-Ki Kim; Mun-Il Kang; Kyoung-Oh Cho

ABSTRACT Bovine coronavirus (BCoV) is an etiological agent associated with winter dysentery (WD), prevalent in adult cattle during the winter. Although we previously detected, isolated, and characterized BCoV strains from adult cattle with WD (WD-BCoV strains) during the winter in South Korea, the precise epidemiology, as well as the causative agent of diarrhea in adult cattle in the warmer seasons, has not been examined. We examined 184 diarrheic fecal specimens collected from 75 herds of adult cattle from seven provinces during the spring (warm), autumn (warm), and summer (hot) seasons. Bovine coronavirus-positive reactions were detected for 107 (58.2%) diarrheic fecal samples (in 47/75 herds). Of these 107 positive samples, 90 fecal samples from 33 herds tested positive for BCoV alone and 17 fecal samples from 14 herds also tested positive for other pathogens. Biological comparisons between the 9 BCoV strains isolated in this study and the 10 previously isolated WD-BCoV strains revealed that there was no receptor-destroying enzyme (RDE) activity against mouse erythrocytes in the 9 BCoV strains but the 10 WD-BCoV strains had high RDE activity. Phylogenetic analysis of the spike (S) and hemagglutinin/esterase (HE) proteins revealed that all the Korean BCoVs clustered together regardless of season and were distinct from the other known BCoVs, suggesting a distinct evolutionary pathway for the Korean BCoVs. These and previous results revealed a high prevalence and widespread geographical distribution of BCoV, suggesting that this virus is endemic in adult cattle with diarrhea in all seasons in South Korea.


Journal of Clinical Microbiology | 2006

Molecular Characterization of Novel G5 Bovine Rotavirus Strains

Sung-Hee Park; Linda J. Saif; Cheol Won Jeong; Guem-Ki Lim; Sang-Ik Park; Ha-Hyun Kim; Su-Jin Park; You-Jung Kim; Jae-Ho Jeong; Mun-Il Kang; Kyoung-Oh Cho

ABSTRACT Group A rotaviruses are a major cause of acute gastroenteritis in young children as well as many domestic animals. The rotavirus genome is composed of 11 segments of double-stranded RNA and can undergo genetic reassortment during mixed infections, leading to progeny viruses with novel or atypical phenotypes. The aim of this study was to determine if the bovine group A rotavirus strains KJ44 and KJ75, isolated from clinically infected calves, share genetic features with viruses obtained from heterologous species. All 11 genes sequences of the KJ44 and KJ75 strains were sequenced and analyzed. The KJ44 VP4 had 91.7% to 96.3% deduced amino acid identity to the bovine related P[1] strain, whereas the KJ75 strain was most closely related to the bovine related P[5] strain (91.9% to 96.9% amino acid identity). Both KJ44 and KJ75 strains also contained the bovine related VP3 gene. The remaining 9 segments were closely related to porcine group A rotaviruses. The KJ44 and KJ75 strains showed high amino acid identity to the G5 rotaviruses, sharing 90.4% to 99.0% identity. In addition, these strains belonged to the NSP4 genotype B, which is typical of porcine rotaviruses and subgroup I, with the closest relationship to the porcine JL-94 strain. These results strongly suggest that bovine rotavirus strains with the G5 genotype occur in nature as a novel G genotype in cattle as a result of a natural reassortment between bovine and porcine strains.


Virus Research | 2005

Molecular analysis of S gene of spike glycoprotein of winter dysentery bovine coronavirus circulated in Korea during 2002-2003.

Jae-Ho Jeong; Gye-Yeop Kim; Soon-Seek Yoon; Su-Jin Park; You-Jung Kim; Chang-Min Sung; Sung-Shik Shin; Bong-Joo Lee; Mun-Il Kang; Nam-Yong Park; Hong-Bum Koh; Kyoung-Oh Cho

Abstract Since the molecular analysis of spike (S) glycoprotein gene of bovine coronavirus (BCoV) has been conducted and compared mainly among American and Canadian isolates and/or strains, it is unclear whether BCoV circulated in the other countries are distinctive in genetic characteristics. In the present study, we analyzed the S glycoprotein gene to characterize 10 winter dysentery (WD) coronavirus strains circulated in Korea during 2002–2003 and compared the nucleotide (nt) and deduced amino acid (aa) sequences with the other known BCoV. The phylogenetic analysis of the entire S glycoprotein gene revealed that the aa sequences of all Korean WD strains were more homologous to each other and were very closely related to respiratory bovine coronavirus (RBCV) strain OK and enteric bovine coronavirus (EBCV) strain LY-138, but were distinct from the other known BCoVs. Based on the phylogenetic analysis of the hypervariable region of the S1 subunit, all Korean WD strains clustered with the respiratory strain OK, BCQ3994 and the enteric strain LY-138, while the Canadian BCQ calf diarrhea and WD strains, and the American RBCV LSU, French EBCV F15 and avirulent VACC, L9, and Mebus strains clustered on a separate major branch. These data suggest that the WD strains circulated in Korea had a genetic property of both RBCV and EBCV and were significantly distinct from the ancestral enteric strain.


Journal of Veterinary Diagnostic Investigation | 2005

Segmental Aplasia of Uterine Body in an Adult Mixed Breed Dog

Ki-Seok Oh; Chang-Ho Son; Bang-sil Kim; Shun-Shin Hwang; You-Jung Kim; Su-Jin Park; Jae-Ho Jeong; Cheol Won Jeong; Sung-Hee Park; Kyoung-Oh Cho

Segmental aplasia of the uterine body was diagnosed in a 5-year-old, mixed breed bitch. Abdominal radiography and transabdominal ultrasonography revealed marked dilation of fluid-filled uterine horns with no evidence of a uterine body. Sex hormone assays did not detect the presence of estradiol-17 (β; however, progesterone (2 ng/ml) was found in the serum, indicating anestrus. On gross examination of the reproductive tract, the uterine body was absent, apparently never formed. In its place, a cord-like piece of tissue was identified as an aplastic/dysplastic remnant, connecting the cervix and right uterine horn. The tip of the cord-like piece branched into 5 string-like pieces of tissue, 1 of which was connected to the region dividing the left and right uterine horns. Both the uterine horns were dilated markedly revealing hydrometra. Histologically, uterine body remnant tissues from the endometrium, myometrium, and perimetrium were detected in proximal and distal parts of the uterine body. The string-like piece of tissue connecting the uterine body remnant and the uterine horn consisted of a round cluster of smooth muscle cells surrounding a central core of adipose tissue with blood vessels. It was concluded that the hydrometra observed in both uterine horns was induced by an obstruction resulting from segmental aplasia in the uterine body. This is the first known report of segmental aplasia in the uterine body of a bitch.


Virus Genes | 2006

Molecular characterization of HE, M, and E genes of winter dysentery bovine coronavirus circulated in Korea during 2002-2003.

Chin-Koo Ko; Mun-Il Kang; Geum-Ki Lim; Gye-Yeop Kim; Soon-Seek Yoon; Jong-Tae Park; Cheol Won Jeong; Sung-Hee Park; Su-Jin Park; You-Jung Kim; Jae-Ho Jeong; Sang-Ki Kim; Sang-Ilk Park; Ha-Hyun Kim; Kyoung-Yoon Kim; Kyoung-Oh Cho

The different bovine coronavirus (BCoV) strains or isolates exhibited various degrees of substitutions, resulting in altered antigenicity and pathogenicity of the virus. In the previous our study, we demonstrated that the spike glycoprotein gene of Korean winter dysentery (WD) BCoV had a genetic property of both enteric (EBCV) and respiratory BCoV (RBCV) and were significantly distinct from the ancestral enteric strains. In the present study, therefore, we analyzed the other structure genes, the hemagglutinin/esterase (HE) protein, the transmembrane (M) protein and the small membrane (E) protein to characterize 10 WD BCoV circulated in Korea during 2002–2003 and compared the nucleotide and deduced amino acid sequences with the other known BCoV. Phylogenetic analysis indicated that the HE gene among BCoV could be divided into three groups. The first group included only RBCV, while the second group contained calf diarrhea BCoV, RBCV, WD and EBCV, respectively. The third group possessed only all Korean WD strains which were more homologous to each other and were sharply distinct from the other known BCoV, suggesting Korean WD strains had evolutionary distinct pathway. In contrast, the relative conservation of the M and E proteins of BCoV including Korean WD strains and the other coronaviruses suggested that structural constraints on these proteins are rigid, resulting in more limited evolution of these proteins. In addition, BCoV and human coronavirus HCV-OC43 contained four potential O-glycosylation sites in the M gene. However, the M gene sequence of both BCoV and HCV-OC43 might not contain a signal peptide, suggesting the M protein might be unlikely to be exposed to the O-glycosylation machinery in vivo.


Australian Veterinary Journal | 2004

Comparison of one-step RT-PCR and a nested PCR for the detection of canine distemper virus in clinical samples.

Shin Yj; Kyoung-Oh Cho; Hyeon-Seo Cho; Kang Sk; Hyeoung-Joon Kim; You-Jung Kim; Hae-Sim Park; Nam-Yong Park


Journal of Veterinary Medical Science | 2005

Detection and isolation of winter dysentery bovine coronavirus circulated in Korea during 2002-2004.

Jae-Ho Jeong; Gye-Yeop Kim; Soon-Seek Yoon; Su-Jin Park; You-Jung Kim; Chang-Min Sung; Oh-Jun Jang; Sung-Shik Shin; Hong-Bum Koh; Bong-Joo Lee; Chai-Yong Lee; Mun-Il Kang; Hyun-Jin Kim; Nam-Yong Park; Kyoung-Oh Cho


Journal of Veterinary Diagnostic Investigation | 2006

Relationship between DNA Ploidy and Proliferative Cell Nuclear Antigen Index in Canine Hemangiopericytoma

Seong-Kwi Kang; Nam-Yong Park; Ho-Sung Cho; Sung-Shik Shin; Mun-Il Kang; Sang-Ki Kim; Changbaig Hyun; In-Chul Park; Jong-Tack Kim; Cheol Won Jeong; Sung-Hee Park; Su-Jin Park; Jae-Ho Jeong; You-Jung Kim; Kenji Ochiai; Takashi Umemura; Kyoung-Oh Cho


Journal of Veterinary Medical Science | 2008

Molecular Analysis of Endogenous Avian Leukosis/Sarcoma Virus Genomes in Korean Chicken Embryos

You-Jung Kim; Sang-Ik Park; Su-Jin Park; Ha-Hyun Kim; Yong-Wun Jung; Jung-Taek Kwon; Byoung-Gui Jang; Hak-Kue Kim; Kyoung-Oh Cho


Laboratory Animal Research | 2007

Seroprevalence of Bovine Coronavirus in Adult Dairy and Beef Cattle in Korea

Ha-Hyun Kim; Eun-Sik Park; Chang-Min Sung; Gye-Yeop Kim; Su-Jin Park; Sang-Ik Park; Sung-Hee Park; Cheol Won Jeong; You-Jung Kim; Kyoung-Oh Cho

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Kyoung-Oh Cho

Chonnam National University

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Su-Jin Park

Chonnam National University

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Jae-Ho Jeong

Chonnam National University

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Mun-Il Kang

Chonnam National University

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Cheol Won Jeong

Chonnam National University

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Sung-Hee Park

Chonnam National University

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Ha-Hyun Kim

Chonnam National University

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Nam-Yong Park

Chonnam National University

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Sang-Ik Park

Chonnam National University

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