Young-Keun Yang

A Rhodamine−Hydroxamic Acid-Based Fluorescent Probe for Hypochlorous Acid and Its Applications to Biological Imagings

A new rhodamine-hydroxamic acid-based fluorescent chemosensor for the rapid detection of HOCl in aqueous media was developed. The system, which utilizes an irreversible HOCl-promoted oxidation reaction, responds instantaneously at room temperature with linear proportionality to the amount of HOCl. This system is highly selective for HOCl over other reactive oxygen species (ROS) and highly sensitive in aqueous solutions. Biological imaging studies using living cells and organisms (A549 cells and zebrafish) to detect HOCl are successfully demonstrated.

A gold(III) ion-selective fluorescent probe and its application to bioimagings.

A highly selective and sensitive fluorescent chemosensor for Au(3+) has been reported. The system utilizes an irreversible Au(3+)-promoted cyclization reaction of a rhodamine amide tethered with an alkyne. The probe can sense Au(3+) ions selectively over other biologically relevant metal ions, and approximately 50 nM of Au(3+) could be readily detected in aqueous media. Fluorescent imaging of Au(3+) in living cells is also successfully demonstrated.