Young-Moo Na

Exercise therapy effect on natural killer cell cytotoxic activity in stomach cancer patients after curative surgery

OBJECTIVE To evaluate the effect of early exercise therapy on the natural killer cell cytotoxic activity (NKCA) of patients who had undergone curative resection of stomach cancer. DESIGN Prospective study. PATIENTS Thirty-five stomach cancer patients who had undergone curative surgery were randomly divided into an exercise group (n = 17) and a control group (n = 18). INTERVENTION From postoperative day 2, moderated exercise using arm and bicycle ergometers performed twice a day, 5 times a week, for 14 days. The intensity of exercise was 60% of maximal heart rate. Venous blood samples were obtained on postoperative days 1, 7, and 14. MAIN OUTCOME MEASURE Mean sequential change of NKCA. RESULTS The mean sequential change of NKCA decreased until postoperative day 7 and then increased. Mean NKCA of day 7 decreased in both groups, compared with that at postoperative day 1. At day 14, the mean NKCA of the exercise group demonstrated a significant increase compared with that of the control group (p < .05). CONCLUSION This study suggests that early moderate exercise has a beneficial effect on the function of in vitro NK cells in stomach cancer patients after curative surgery.

Poster 2: Postural control in elderly women with knee osteoarthritis1

Abstract Objective: To examine the effect of painful knee osteoarthritis on baseline balance and the relationship between balance measures and clinical measures. Design: Cross-sectional, observational, and controlled study. Setting: Sports medicine laboratory. Participants: 22 healthy women and 26 women with unilateral knee pain (age range, 60–80y). Interventions: Not applicable. Main Outcome Measures: Outcome measures included 6 force platform measures, ambulatory and transfer knee-pain intensity score (visual analog scale [VAS]), and disease burden (Kellgren-Lawrence score). The force platform measures obtained using the Balance Master System, which included weight-bearing symmetry, sway, and movement time during performing 6 tasks: weight bearing and squat, unilateral stance with eyes open, rhythmic weight shift, sit to stand, tandem walk, and step up and over. Results: On-axis velocity (deg/s) and directional control (%) in front and back rhythmic weight shift, and rising index (% body weight) in sit to stand were lower in women with unilateral knee pain ( P P P r =.42). Conclusion: Avoidance of pain associated with limb loading and decline in postural control ability were demonstrated in elderly women with unilateral knee pain. Based on these results, further studies should be carried out to correlate the avoidance and decline with the falls in patients with painful knee osteoarthritis.