Young Nam Woo
Hanyang University
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Featured researches published by Young Nam Woo.
Acta Oncologica | 1998
Gu Kong; Ki Yong Shin; Young Ha Oh; Jong Jin Lee; Hae Young Park; Young Nam Woo; Jung Dal Lee
We investigated the Bcl-2 and P53 protein expressions in 89 patients with bladder cancers using immunohistochemical analysis. In superficial tumors, the times of tumor recurrence and progression were significantly shorter in the P53-positive group than in the negative group (p < 0.005, p < 0.05, respectively). In invasive tumors, the disease-specific actuarial survivals were significantly lower in the P53 and Bcl-2-positive groups (p <0.05, p < 0.025, respectively). In multivariate analysis, overexpression of p53 and Bcl-2 had independent prognostic value for survivals in invasive tumor, while disease-free survival was related independently to overexpression of p53 in superficial tumor. The results of our assessment for chemoeffectiveness revealed that the patients with Bcl-2-positive tumors had significantly lower response rates than those with Bcl-2-negative tumors (p < 0.05). We conclude that p53 expression is an independent, poor prognostic marker in invasive tumors as well as in superficial tumors and that overexpression of Bcl-2 is independently associated with a reduced-survival in patients with invasive tumors. These prognostic differences related to P53 and Bcl-2 expression in invasive bladder cancers may be partly due to chemo- or radio-sensitivity in relation to apoptotic process.
Korean Journal of Radiology | 2000
Hak Soo Lee; Byung Hee Koh; Jang Wook Kim; Yongsoo Kim; Hyun Chul Rhim; On Koo Cho; Chang Kok Hahm; Young Nam Woo; Moon Hyang Park
Renal hemangioma is an uncommon benign tumor which usually causes painless or painful gross hematuria. Its preoperative diagnosis is extremely difficult or even impossible. We experienced three cases of renal hemangioma, located mainly at the pelvocalyceal junction or in the inner medulla. US demonstrated variable echogenecity, and CT revealed a lack of significant enhancement. Where there is gross hematuria in a young adult, especially when the renal mass located in the pelvocalyceal junction or inner medulla shows little enhancement on CT, renal hemangioma should form part of the differential diagnosis.
Cancer Letters | 2000
Ki Yong Shin; Hong Sang Moon; Hae Young Park; Tchun Yong Lee; Young Nam Woo; Hyun Jun Kim; Su Jeen Lee; Gu Kong
Abstract We have investigated the effects of tumor necrosis factor-α (TNF-α) and interferon (INF-γ), the potent Bacillus Calmette–Guerin (BCG)-induced cytokines on the production of MMP-2, MMP-9, TIMP-1, TIMP-2 and MT1-MMP in high grade human bladder cancer cell lines, T-24, J-82 and HT-1376 cell lines. MMP-2 expression and activity were decreased in T-24 cells treated with both cytokines in a dose dependent manner. However, J-82 cells treated with TNF-α and INF-γ revealed dose dependent increases of MMP-9 expression and activity with similar baseline expression and activity of MMP-2. HT-1376 cells after exposure to TNF-α only enhanced the expression and activity of MMP-9. These results indicate that TNF-α and INF-γ could regulate the production of MMP-2 or MMP-9 on bladder cancer cells and their patterns of regulation are cell specific. Furthermore, this diverse response of bladder cancer cells to TNF-α and INF-γ suggests that BCG immunotherapy may enhance the invasiveness of bladder cancer in certain conditions with induction of MMPs.
BJUI | 2002
Seung-June Oh; Kyung-Yong Kim; Kyung-Ah Kim; Kwon-Bae Kim; K.K. Kim; J.S. Kim; Hyeon-jun Kim; Young Nam Woo; Y.L. Yoon; Sunmin Lee; Sang Won Han; S.I. Lee; Hwang Choi
Objective To evaluate knowledge about the foreskin and circumcision, and to understand the attitudes of parents to circumcision in Korea, where circumcision in childhood is widely practised with no particular religious or medical background.
Journal of Endourology | 2002
Ki Yong Shin; Hyun Jun Park; Jong Jin Lee; Hae Young Park; Young Nam Woo; Tchun Yong Lee
BACKGROUND AND PURPOSE Tuberculous ureteral stricture causing progressive obstructive uropathy commonly complicates renal tuberculosis. The aim of our study was to evaluate the effectiveness of early ureteral stenting or percutaneous nephrostomy (PCN) in patients with tuberculous ureteral strictures. PATIENTS AND METHODS Seventy-seven patients (84 renal units) with tuberculous ureteral strictures were analyzed. We evaluated the final outcome of involved kidneys with three different managements: medication only (N = 37), medication plus ureteral stenting (N = 28), or medication plus PCN (N = 19). RESULTS The overall nephrectomy rate was 51%. In patients treated with medication only, the nephrectomy rate was 73%, whereas the nephrectomy rate was 34% in patients treated with medication plus early ureteral stenting or PCN. The rate of reconstructive surgery for ureteral strictures also was significantly different for patients treated with medication only (8%) and those receiving medication plus early ureteral stenting or PCN (49%). Spontaneous resolution of the strictures was noted in 6 of the 12 renal units that were managed with early ureteral stenting. CONCLUSIONS Early ureteral stenting or PCN in patients with tuberculous ureteral strictures may increase the opportunity for later reconstructive surgery and decrease the likelihood of renal loss.
International Journal of Antimicrobial Agents | 2004
Seung Ju Lee; Sang Don Lee; In Rae Cho; Bong Suck Sim; Jeong Gu Lee; Chul Sung Kim; Min Eui Kim; Yong Hyun Cho; Young Nam Woo
Journal of Korean Medical Science | 1995
Ho Jung Kim; Joon Yong Park; Sang Mok Kim; Young Nam Woo; Byung Hee Koh; Oh Koo Cho; Young Hyeh Ko; Moon Hyang Park
Journal of Korean Medical Science | 1989
Hwang Choi; Kwang Myung Kim; Sung Kun Koh; Kwang Sae Kim; Young Nam Woo; Jong Byung Yoon; Seung Kang Choi; Si Whang Kim
Korean Journal of Urology | 2007
Seoung Jin Lee; Yong Tae Kim; Tchun Yong Lee; Young Nam Woo
Korean Journal of Urology | 2006
Sung Yul Park; Hae Young Park; Young Nam Woo