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Featured researches published by Younghoon Lee.


Nucleic Acids Research | 2010

Recognition and discrimination of target mRNAs by Sib RNAs, a cis-encoded sRNA family

Kook Han; Kwang-sun Kim; Geunu Bak; Hongmarn Park; Younghoon Lee

Five Sib antitoxin RNAs, members of a family of cis-encoded small regulatory RNAs (sRNAs) in Escherichia coli, repress their target mRNAs, which encode Ibs toxins. This target repression occurs only between cognate sRNA–mRNA pairs with an exception of ibsA. We performed co-transformation assays to assess the ability of SibC derivatives to repress ibsC expression, thereby revealing the regions of SibC that are essential for ibsC mRNA recognition. SibC has two target recognition domains, TRD1 and TRD2, which function independently. The target site for TRD1 is located within the ORF of ibsC, whereas the target site for TRD2 is located in the translational initiation region. The TRD1 sequence is sufficient to repress ibsC expression. In contrast, TRD2 requires a specific structure in addition to the recognition sequence. An in vitro structural probing analysis showed that the initial interactions at these two recognition sites allowed base-pairing to progress into the flanking sequences. Displacement of the TRD1 and TRD2 domains of SibC by the corresponding domains of SibD changed the target specificity of SibC from ibsC to ibsD, suggesting that these two elements modulate the cognate target recognition of each Sib RNA by discriminating among non-cognate ibs mRNAs.


The Nineteenth Annual Meeting of the RNA Society | 2014

Promoter elements required for expression of BC200 RNA in Hela cells

Younghoon Lee; Young Mi Kim; Jungmin Lee; Heegwon Shin


한국미생물학회 학술대회논문집 | 2013

Recognition and Discrimination of Target mRNAs by sRNAs for Gene Silencing in Escherichia coli

Younghoon Lee; Hongmarn Park; Kook Han; Geunu Bak; Sun Chang Kim; Kwang-sun Kim


The 12th Asian Conference on Transcription | 2012

Promoter Analysis for BC200 RNA Gene Expressionin HeLa Cells

Young Mi Kim; Jungmin Lee; Heegwon Shin; Younghoon Lee


The 12th Asian Conference on Transcription | 2012

Autoregulation of 6S RNA Biogenesis

Jiyoung Lee; Kwang-sun Kim; Hongmarn Park; Geunu Bak; Younghoon Lee


The 23th Annual meeting of the Korean society for Molecular Biology | 2011

BC200, a noncoding RNA, promotes cell migration and invasion in tumor cells

Heegwon Shin; Jungmin Lee; Young Mi Kim; Geunu Bak; Kwang-sun Kim; Younghoon Lee


2011 KSBMB Annual Meeting | 2011

Promoter elements for efficient expression of BC200 RNA in HeLa cells

Young Mi Kim; Jungmin Lee; Heegwon Shin; Younghoon Lee


한국올리고핵산치료학회 2010년 학술대회 | 2010

Interaction of Sib RNAs, a cis-encoded sRNA family, with their target mRNAs

Kook Han; Kwang-sun Kim; Geunu Bak; Hongmarn Park; Younghoon Lee


2010 KSBMB ANNUAL MEETING | 2010

3` end of 6S RNA is initiated by rho-dependent termination of ssrS transcription in Escherichia coli

Huiseok Chae; Kook Han; Kwang-sun Kim; Younghoon Lee


MSK's 50th Anniversary International Symposium on Microbiology 2009 | 2009

Control of RNA Stability for Gene Function

Younghoon Lee; Yool Kim; Kwang-sun Kim; Kook Han; Jae-hyeong Ko

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Jungmin Lee

Seoul National University

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